Product Name: (-)-R-Norepinephrine Bitartrate
Chemical Name: (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol hydrogen (+)-tartrate
CAS Number: 62-31-7
Synonyms: Levarterenol bitartrate, Noradrenaline bitartrate
Recommended Use: Laboratory chemicals, pharmaceutical research
Supplier: [Company contact information, phone number, and emergency contact]
Emergency Phone Number: [Emergency number]
GHS Classification: Acute toxicity (oral), Skin irritation, Eye irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed; May cause irritation to skin, eyes, and respiratory system
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust; Wash thoroughly after handling; Use protective equipment; Contain and collect spillage
Potential Health Effects: Inhalation causes respiratory irritation, ingestion may lead to nausea and cardiovascular effects, skin and eye contact result in irritation
Target Organs: Heart, central nervous system, eyes, skin
Chemical Identity: (-)-R-Norepinephrine bitartrate
CAS Number: 62-31-7
Concentration: >98% by weight
Impurities: Trace amounts of related catecholamines and tars
Molecular Formula: C8H11NO3·C4H6O6
Molecular Weight: 319.28 g/mol
Inhalation: Remove affected person to fresh air, keep at rest, seek medical advice if symptoms persist
Skin Contact: Immediately wash exposed skin with soap and plenty of water, remove contaminated clothing
Eye Contact: Flush eyes with gentle stream of water for at least 15 minutes, lifting eyelids, obtain medical attention
Ingestion: Do not induce vomiting, rinse mouth fully with water, call poison control center or medical professional for guidance
Most Important Symptoms/Effects: Nausea, dizziness, elevated heart rate, agitation, and irritation
Notes for Physician: Provide symptomatic treatment, monitor cardiovascular and respiratory function, no specific antidote known
Suitable Extinguishing Media: Use water spray, dry powder, carbon dioxide, or foam
Specific Hazards: Combustion yields carbon monoxide, carbon dioxide, nitrogen oxides, other irritating and toxic fumes
Advice for Firefighters: Wear full protective clothing and self-contained breathing apparatus to avoid exposure to hazardous decomposition products
Firefighting Procedures: Prevent runoff from entering water systems, cool containers with water spray to reduce risk of explosion due to heat
Explosion Data: Not sensitive to mechanical impact or static discharge, but dust can form explosive mixtures with air
Personal Precautions: Wear lab coat, gloves, safety goggles, and dust mask or respirator
Environmental Precautions: Prevent entry into drains, surface waters, and groundwater
Methods for Cleaning Up: Scoop up and transfer to properly labeled waste container, ventilate area, wash residue with water and detergent, dispose of waste in compliance with regulations
Spill Response: For small spills, carefully sweep up; for large spills, isolate area and contact emergency services
Handling: Use in a chemical fume hood, wear appropriate personal protective equipment, avoid dust generation and inhalation, handle with care to prevent contact with skin and eyes
Storage Conditions: Store in a tightly closed container, in a cool, dry, and well-ventilated place, away from heat, moisture, light, and incompatible materials such as strong oxidizers
Incompatibilities: Strong acids, strong bases, oxidizing agents
Additional Notes: Keep out of reach of unauthorized personnel, label containers clearly, do not use after expiration date
Engineering Controls: Work in a chemical fume hood, use adequate exhaust ventilation
Personal Protection: Wear protective gloves (nitrile recommended), safety goggles, and a laboratory coat
Respiratory Protection: Where dust may be generated, use a NIOSH-approved respirator
Hygiene Measures: Wash hands before breaks and at end of work, do not eat or drink near the working area
Occupational Exposure Limits: No occupational exposure limits established specifically for (-)-R-Norepinephrine bitartrate
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: 3.0 - 5.0 (5% solution)
Melting Point: 240–250°C (decomposes)
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, slightly soluble in alcohol, insoluble in most organic solvents
Density: ~1.5 g/cm³
Partition Coefficient: Log Kow < 1
Vapor Pressure: Not applicable
Flash Point: Not applicable
Decomposition Temperature: 240°C and above
Other Properties: Stable under recommended storage conditions, sensitive to light and moisture
Chemical Stability: Stable under usual laboratory and storage conditions, sensitive to light and moisture
Conditions to Avoid: Exposure to air, heat, strong acids or bases, and oxidizing agents
Incompatible Materials: Strong oxidizing agents, strong acids or bases, certain metals
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, toxic fumes
Polymerization: No known hazardous polymerization expected
Routes of Exposure: Inhalation, ingestion, dermal contact, eye contact
Acute Toxicity: Causes irritation to respiratory tract, eyes, skin; ingestion may cause systemic effects including tachycardia, hypertension, headache, anxiety, and rarely cardiovascular collapse
Chronic Effects: Prolonged exposure can influence blood pressure regulation and central nervous system
LD50 (Oral, rat): 103 mg/kg
Irritation: Skin, eye, and respiratory irritant in animal models
Sensitization: Not classified as sensitizer
Carcinogenicity: No data available suggesting carcinogenic potential
Reproductive Toxicity: Insufficient data
Mutagenicity: No data available
Other Information: Symptoms may be delayed; always seek medical attention after significant exposure
Toxicity to Aquatic Life: May be harmful to aquatic organisms through acute exposure
Persistence and Degradability: Expected to degrade but may persist if released in large quantities
Bioaccumulative Potential: Low, based on Log Kow
Mobility in Soil: Moderate mobility in soil and water; water-soluble and may leach
Other Adverse Effects: No known significant environmental effects
Precaution: Avoid release to environment, proper containment and disposal practices
Waste Disposal Methods: Dispose of in compliance with local, regional, and national regulations for chemical and pharmaceutical waste
Container Handling: Rinse empty containers with water, triple rinse considered best practice, then dispose of as hazardous waste
Environmental Precautions: Do not pour into drains or water bodies, minimize waste generation, use licensed hazardous waste disposal contractor where appropriate
UN Number: Not classified as dangerous good by transport regulations
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: Not considered marine pollutant
Special Precautions: Ship in original packaging or well-sealed containers, protect from moisture and sunlight, provide necessary documentation and hazard information for emergency responders
U.S. TSCA: Listed or excluded
EU REACH: Exempt for scientific research, not subject to standard registration
OSHA Hazards: Hazardous (irritant)
SARA / CERCLA / RCRA: Not listed as hazardous waste or regulated substance
WHMIS (Canada): D2B (Toxic Material Causing Other Toxic Effects)
Label Requirements: Chemical name, potential hazards, precautionary statements, responsible party contact
Other Regulations: Compliance with all applicable international, federal, state, and local regulations required
Workplace Classification: Hazardous material, follow laboratory and institutional chemical hygiene plans
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