Product Name: (R)-Chloro-1,2-propanediol
Chemical Formula: C3H7ClO2
CAS Number: 12768-91-1
Synonyms: (R)-1-Chloro-2,3-propanediol; Glycidol hydrochloride
Recommended Use: Industrial applications, research purposes, chemical synthesis
Manufacturer Info: Full Company Name, Address, Phone Number, Emergency Contact
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin irritation, eye damage
Pictograms: Skull and crossbones, exclamation mark, corrosive
Signal Word: Danger
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation, possible carcinogen, toxic to aquatic life
Precautionary Statements: Use PPE, avoid inhaling fumes or contacting skin and eyes, environmental precautions, keep away from children
Chemical Name: (R)-Chloro-1,2-propanediol
Concentration: ≥98%
Impurities: Trace components of epichlorohydrin, moisture (<1%)
Other Components: No additives or solvents present
Molecular Weight: 110.54 g/mol
Inhalation: Move person to fresh air immediately, support breathing if there are issues, seek medical attention for persistent symptoms.
Skin contact: Quickly remove contaminated clothing, wash affected area with soap and plenty of water for at least 15 minutes, seek medical advice if symptoms continue.
Eye contact: Rinse eyes carefully with water for at least 15 minutes, remove contact lenses, seek medical attention if irritation persists.
Ingestion: Do not induce vomiting, rinse mouth thoroughly with water, seek immediate medical attention.
Most important symptoms: Skin and eye irritation, gastric discomfort, possible breathing difficulties, symptoms may be delayed.
Suitable Extinguishing Media: Water spray, dry chemical, CO2, foam
Unsuitable Media: Avoid direct water jet
Special Hazards: Releases toxic gases such as HCl, CO, CO2 on combustion
Protective Equipment: Use self-contained breathing apparatus, chemical-resistant clothing
Firefighting Instructions: Eliminate all ignition sources, keep containers cool with water spray, evacuate area if needed
Specific Hazards: Vapors may form explosive mixtures with air, run-off from fire control may pollute water
Personal Precautions: Use gloves, protective clothing, goggles, respirator in confined areas, ensure adequate ventilation, control dust/fumes
Environmental Precautions: Prevent from entering drains, soil, and waterways, alert local authorities if large spill occurs
Containment: Stop the leak if safe, dike area to prevent further spread
Cleanup Methods: Absorb with inert material such as sand or earth, avoid contact with skin and eyes, collect residue using non-sparking tools, place in labeled containers for disposal
Handling: Handle in a chemical fume hood, avoid inhaling vapors or dust, wear protective gloves, goggles, and lab coat, wash hands thoroughly after contact, do not eat or drink in work area
Storage: Store in original, tightly closed containers, keep in a cool, dry well-ventilated area away from sources of ignition, incompatible materials (strong acids, bases, oxidants), segregate from foodstuffs, label shelves clearly
Additional Precautions: Use spill trays, maintain appropriate inventory levels, inspect containers regularly for leaks
Exposure Limits: No occupational exposure limits established, use lowest reasonable exposure
Engineering Controls: Fume hoods, local exhaust ventilators, strict access control to hazardous areas
Personal Protection: Nitrile gloves (thick, chemical grade), safety goggles, laboratory coat or chemical apron, closed footwear, positive pressure respirator for spills or poor ventilation
Hygiene Measures: Remove and wash contaminated clothing, do not use shared PPE, wash hands and face thoroughly after handling
Monitoring Methods: Regular air monitoring for vapors, visual checks for leaks and spills
Appearance: Clear to slightly yellowish oily liquid
Odor: Faint, slightly sweet or ether-like
Odor Threshold: Not established
pH: Not available
Melting Point: -45°C
Boiling Point: 187-192°C
Flash Point: 92°C (closed cup)
Auto-ignition Temperature: 435°C
Explosive Limits: Not available
Vapor Pressure: Low (approx. 0.2 mmHg at 20°C)
Vapor Density: >1 (air=1)
Density: 1.32 g/cm³ at 20°C
Solubility: Miscible with water, soluble in alcohols and organic solvents
Evaporation Rate: Slower than water
Partition Coefficient (log Kow): -0.52
Viscosity: Not established
Chemical Stability: Stable under recommended storage, avoid extremes of temperature and humidity
Reactions: May react with strong oxidizers, acids, bases to produce hazardous compounds
Hazardous Decomposition: Releases hydrogen chloride, carbon monoxide, chloro-organic compounds on decomposition or combustion
Conditions to Avoid: High temperatures, open flame, direct sunlight, incompatible materials
Polymerization: No known risk of hazardous polymerization
Routes of Exposure: Inhalation, skin, eyes, ingestion
Acute Toxicity: Oral LD50 (rat): ~1000 mg/kg, dermal LD50 (rabbit): >2000 mg/kg
Chronic Effects: Repeated exposure may cause liver, kidney, and nervous system damage, chronic skin disorders
Carcinogenicity: Classified as possible human carcinogen based on animal studies
Mutagenicity: Evidence of genotoxic effects
Symptoms: Eye or skin redness, headache, nausea, dizziness, coughing, breathlessness, long-term effects target organs
Additional Information: No threshold value determined for occupational exposure
Ecotoxicity: Harmful to aquatic life (acute and chronic), LC50 (fish, 96h): 25-50 mg/L
Persistence/Degradability: Slowly biodegradable, may persist in environment
Bioaccumulation: Low potential (log Kow negative)
Mobility: High solubility increases risk of leaching to groundwater
Other Hazards: Toxic to microorganisms, disrupts aquatic ecosystems, not considered a PBT/vPvB substance
Disposal: Treat as hazardous chemical waste, consult local waste authorities
Methods: Incineration at approved facility preferred, small amounts neutralized with absorbent and placed in sealed containers for hazardous waste pickup
Contaminated Packaging: Empty containers must be triple rinsed, punctured, and disposed of as hazardous waste
Sewage Disposal: Do not release into drains or watercourses
Regulatory Compliance: Follow all regional and national regulations governing chemical waste
UN Number: 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (contains (R)-Chloro-1,2-propanediol)
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
Labels Required: Flammable liquid label, environmental hazard label
Special Provisions: Avoid contact with incompatible materials, protect from heat, ensure containers are properly sealed
Transport in Bulk: Follow MARPOL Annex II and IBC code
TSCA Status: Listed in Toxic Substances Control Act inventory (US)
REACH Regulation: Substance subject to registration in Europe, not on SVHC list
GHS Label: Complies with UN GHS classification
OSHA Hazards: Acute toxicity, eye and skin irritant, possible carcinogen
Other Regulatory: Satisfies criteria for chemical hazard communication in many jurisdictions, reportable quantity set by some authorities
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