Product Name: (R)-(+)-3-Chloro-1-phenylpropanol
Chemical Formula: C9H11ClO
Synonyms: (R)-(+)-3-Chloro-1-phenylpropan-1-ol
CAS Number: 115568-46-4
Recommended Use: Laboratory chemical, synthesis intermediate
Supplier Information: Reach out to chemical supplier or manufacturer for full details.
Telephone Number for Emergency: Refer to safety office or regional poison center for urgent questions.
GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Specific target organ toxicity single exposure (Category 3)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation. Causes skin irritation. May cause respiratory irritation.
Pictograms: Exclamation mark symbol signals potential irritation.
Precautionary Statements: Avoid inhalation of vapors or dust. Wear protective gloves and eye protection. Wash hands thoroughly after handling. Use only outdoors or in well-ventilated area. If inhaled, move person into fresh air and keep at rest.
Chemical Name: (R)-(+)-3-Chloro-1-phenylpropanol
CAS Number: 115568-46-4
Purity: ≥98% by weight
Impurities: Trace possible impurities include related phenylpropanol or chloro compound analogues, but full characterization comes straight from supplier documentation.
Stabilizing Additives: Many batches contain trace stabilizer, below 0.1% w/w.
Inhalation: Move person to fresh air. If symptoms persist, call for medical advice. Support breathing with oxygen if available.
Skin Contact: Remove contaminated clothing. Wash thoroughly with soap and water. If irritation occurs, seek medical guidance.
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lifting eyelids. Get medical attention promptly.
Ingestion: Rinse mouth. Do not induce vomiting, give water to dilute, seek urgent medical help if feeling unwell.
Acute Symptoms: Eye stinging, burning sensation in throat or lungs, skin redness, nausea reported in some exposure cases.
Extinguishing Media: Use water spray, foam, dry powder, or carbon dioxide.
Hazards Arising from Combustion: Fire may release hydrogen chloride gas, carbon monoxide, carbon dioxide, and other unidentified fumes.
Advice for Firefighters: Wear full protective gear and NIOSH-approved breathing apparatus. Avoid inhalation of vapor and runoff water from fire control.
Thermal Decomposition: Chlorinated organics and aromatic compounds present particular concern during combustion.
Personal Precautions: Don suitable personal protective equipment—lab coat, safety glasses, gloves appropriate for organic chemicals.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Avoid entering drains or waterways.
Cleanup Methods: Absorb spillage with inert material—sand, universal binder. Collect in suitable container, tightly sealed, for disposal. Ventilate area well, decontaminate with detergent solution.
Handling: Avoid inhalation, ingestion, and direct contact. Work in fume hood when transferring larger quantities. Do not eat, drink, or smoke in work area. Use spark-proof tools for transfer.
Storage Conditions: Keep tightly closed in original container. Store in cool, dry, well-ventilated area. Keep away from oxidizing agents, acids, and sunlight.
Incompatibilities: Alkalis, strong oxidants, and strong acids degrade stability. Do not stack heavy containers.
Exposure Limits: No established occupational exposure limits; practice prudent industrial hygiene.
Engineering Controls: Local exhaust ventilation or fume hood recommended.
Personal Protective Equipment (PPE): Chemical splash goggles, gloves (nitrile or neoprene), lab coat, and, in case of insufficient ventilation, NIOSH-certified respirator. Emergency eyewash and safety shower should be accessible.
Appearance: Clear to pale yellow oily liquid
Odor: Slight sweet or aromatic odor
Molecular Weight: 170.64 g/mol
Boiling Point: Approximately 105-107°C at 2 mmHg
Melting Point: Not established (remains liquid at room temperature)
Flash Point: Estimated above 100°C
Solubility in Water: Slightly soluble; miscible in organic solvents (ethanol, acetone, ether)
Vapor Pressure: Not readily available; use with adequate ventilation
Density: ~1.19 g/cm³ at 20°C
pH: Not applicable; does not form an aqueous solution under typical conditions
Chemical Stability: Maintains integrity under recommended storage. Sensitive to excessive heat or light.
Reactivity: Hydrolyzes slowly with strong acids or bases.
Possibility of Hazardous Reactions: Violent reaction with oxidizers. Combustion forms toxic fumes.
Conditions to Avoid: High temperature, acid or alkali exposure, and direct sunlight.
Incompatible Materials: Strong oxidizing agents, reducing agents, and alkali metals.
Hazardous Decomposition Products: Hydrogen chloride, phenyl-based volatiles.
Routes of Exposure: Skin contact, eye contact, inhalation, ingestion
Acute Toxicity: No major incidents in available literature. Estimated oral LD50 (rat) above 2000 mg/kg.
Symptoms: Skin or respiratory system irritation, burning eyes, headache. Repeated exposure causes dermatitis in sensitive individuals.
Carcinogenicity: No components classified as carcinogen by IARC, NTP, or OSHA.
Chronic Effects: Prolonged skin contact can lead to defatting and chapping. Inhalation in high concentrations depresses central nervous system.
Mutagenicity: No findings indicating genetic toxicity in standard Ames tests.
Aquatic Toxicity: Limited aquatic organism studies. Expected to exhibit moderate chronic toxicity due to benzyl moiety.
Persistence and Degradability: Stable under standard conditions, slow biodegradation suggested by regulatory data.
Bioaccumulative Potential: Moderate potential. Phenyl-containing molecules can build up in aquatic tissue.
Mobility in Soil: Low; low solubility and adsorption to organic matter limits transport.
Other Adverse Effects: Avoid release to surface water, risk of harm to fish and invertebrates without prior treatment.
Waste Handling: Collect and store in sealed, labeled containers for chemical waste pickup. Do not dispose via municipal drains.
Disposal Methods: Controlled incineration in licensed facility, following EPA and local chemical waste regulations.
Contaminated Packaging: Triple rinse containers, send for hazardous waste disposal.
UN Number: Obtained from national transport authority (varies by jurisdiction)
Proper Shipping Name: Organic liquid, n.o.s. (contains 3-Chloro-1-phenylpropanol)
Transport Hazard Class: 6.1 (toxic substances, based on national transport codes)
Packing Group: III
Label Requirements: Toxic, if classified as such in shipping regulations. Follow local transport documentation needs.
SARA Title III (Sections 311/312): Acute health hazard notification applies for laboratory scale use
TSCA: Listed in TSCA Inventory for research and development purposes
REACH: Substance may not be registered for commercial uses in the European Union; refer to supplier or ECHA database
OSHA: Not classified as hazardous chemical under OSHA Hazard Communication Standard, but irritation risks trigger safety requirements
Other National Regulations: Waste codes and labeling rules differ regionally, so confirm with relevant environmental and health authorities. Safety Data Sheets for local workplace use must meet country-specific standards, including GHS adaptation in documentation.
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