Product Name: (R)-(+)-3-chloro 1-phenyl-1-propanol
Chemical Formula: C9H11ClO
CAS Number: 123328-45-2
Synonyms: (R)-(+)-3-chloro-1-phenylpropan-1-ol, (R)-3-chloro-1-phenylpropanol
Recommended Use: Laboratory chemicals, research, synthesis of chiral compounds
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GHS Classification: Skin irritation (Category 2), Eye irritation (Category 2A), Acute toxicity (oral) (Category 4)
Signal Word: Warning
Hazard Statements: Causes skin irritation, causes serious eye irritation, harmful if swallowed
Precautionary Statements: Avoid breathing dust or vapors. Wash skin thoroughly after handling. Use personal protective equipment. Keep away from food and drink. If skin irritation occurs: Get medical advice.
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Potential Health Effects: May cause skin and eye irritation. Ingestion may cause gastrointestinal irritation, nausea, vomiting. Inhalation of vapors may lead to respiratory irritation.
Chemical Name: (R)-(+)-3-chloro 1-phenyl-1-propanol
CAS Number: 123328-45-2
Purity: >98%
Impurities: None known at levels relevant for safety assessment
Molecular Weight: 170.64 g/mol
Inhalation: Move person to fresh air. Seek medical attention if symptoms develop. Remove any source of contamination. Support breathing if needed.
Skin Contact: Remove any contaminated clothing. Wash skin immediately with soap and plenty of water. Medical attention if irritation continues.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids. Remove contact lenses if present. Seek immediate medical help for irritation or persistent pain.
Ingestion: Rinse mouth. Do not induce vomiting unless instructed by a healthcare provider. Seek medical advice as soon as possible.
Notes for Doctors: Treat symptomatically, monitor for signs of central nervous system effects, supportive care only.
Suitable Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Water may be less effective but can be used for cooling containers.
Unsuitable Media: Avoid using high-pressure water streams which could spread the chemical.
Hazardous Combustion Products: Hydrogen chloride, carbon oxides, and other unidentified organic compounds may result from burning.
Protective Equipment for Firefighters: Full protective clothing and self-contained breathing apparatus. Firefighters should avoid exposure to chemical vapors or smoke.
Special Procedures: Move containers from fire area if safe, use water spray for cooling, prevent runoff from entering drains or water courses.
Personal Precautions: Evacuate area and ventilate. Wear protective gloves, goggles, and clothing. Avoid breathing dust, vapor, and mist.
Environmental Precautions: Prevent entry into drains, basements, or waterways. Notify relevant authorities if significant environmental contamination occurs.
Containment and Clean-Up: Use inert absorbent (sand, earth, vermiculite), sweep up, and place material in proper waste container. Wash spill area with water and detergent. Dispose of residue according to local regulations.
Handling: Handle in well-ventilated areas. Avoid breathing vapors, dust, and contact with skin or eyes. Wear appropriate PPE. Do not eat, drink, or smoke during use.
Storage: Keep containers tightly closed in a cool, dry, well-ventilated location away from incompatible substances (strong oxidizers, acids, bases). Keep away from heat and ignition sources. Label storage area as hazardous.
Specific Requirements: Store in original packaging. Use secondary containment to prevent spill spread.
Engineering Controls: Use fume hoods, local exhaust ventilation, or mechanical ventilation to reduce airborne exposure.
Personal Protective Equipment: Nitrile or chemical-resistant gloves, safety glasses with side-shields or goggles, lab coat or chemical-resistant apron, closed-toe shoes.
Respiratory Protection: Use approved respirator with organic vapor cartridge if working with large volumes or poor ventilation.
Hygiene Measures: Wash hands and exposed skin after contact. Remove and wash contaminated clothing before reuse.
Exposure Limits: No specific occupational exposure limits established, but recommended to minimize exposure to lowest possible level.
Appearance: Colorless to pale yellow liquid or crystalline solid
Odor: Mild aromatic
pH: Not applicable (neutral compound)
Melting Point: 38–40 °C (solid form)
Boiling Point: 239–241 °C at 760 mmHg
Flash Point: >110 °C (closed cup)
Evaporation Rate: Not determined
Solubility: Slightly soluble in water, soluble in organic solvents (ethanol, chloroform, ether)
Vapor Density: Heavier than air
Partition Coefficient (Log Pow): Estimated 1.9
Viscosity: Not determined
Relative Density: 1.16 g/cm3 at 25 °C
Refractive Index: 1.538 at 20 °C
Chemical Stability: Stable under normal handling and storage conditions.
Possible Reactions: Reacts with strong oxidizers, acids, and bases.
Hazardous Polymerization: Has not been reported to occur.
Decomposition Products: Hydrochloric acid, carbon monoxide, carbon dioxide under combustion or decomposition.
Conditions to Avoid: High temperatures, direct sunlight, sources of ignition, moisture.
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion.
Acute Toxicity Data: Oral LD50 (rat) estimated >200 mg/kg, based on analogous compounds.
Skin Corrosion/Irritation: Moderate to strong irritant in animal tests.
Serious Eye Damage/Irritation: Causes significant irritation; risk of corneal injury if not flushed soon.
Respiratory Sensitization: May cause irritation of nose, throat, and lungs.
Carcinogenicity/Mutagenicity/Reproductive Toxicity: Not classified as carcinogen or mutagen; no data on reproductive effects.
Chronic Effects: Repeated contact may cause dermatitis or skin sensitization.
Symptoms: Burning in eyes, irritation in respiratory tract, redness, pain or dermatitis in skin.
Ecotoxicity: Low to moderate toxicity to aquatic life based on structural analogs. LC50 (fish, 96h) >10–100 mg/L.
Persistence/Degradability: Likely to degrade slowly in environment under standard conditions.
Bioaccumulative Potential: Moderate potential for bioconcentration, estimated log Kow 1.9 suggests not strongly bioaccumulative.
Mobility in Soil: Will adsorb on organic matter; may migrate if spilled in large quantities.
Other Adverse Effects: No data on specific environmental hazards, but large amounts may harm aquatic environments.
Waste Disposal: Collect in appropriate sealed containers labeled for hazardous chemical waste. Disposal by chemical incineration with flue gas scrubber where permitted.
Contaminated Packaging: Triple rinse containers and dispose according to local, state, and federal requirements.
Special Precautions: Consult local environmental authority for guidance. Avoid contamination of groundwater and sewers.
UN Number: Not regulated (not classified as a dangerous good by most transport regulations)
Proper Shipping Name: Not assigned for standard shipments; ship as laboratory chemical, not otherwise specified.
Transport Hazard Class: Not classified
Packing Group: Not assigned
Marine Pollutant: No
Precautions: Protect containers from physical damage and keep upright. Secure loads to avoid movement in transit.
Regulatory Notes: Transport in compliance with all local, regional, and national regulations.
TSCA: Listed or exempt as research chemical
REACH Registration: Pre-registered or exempt in EU research context
OSHA Hazard Communication: This material contains hazardous components as defined by OSHA HCS.
SARA Title III Sections 302/304/313: Not subject to reporting requirements at typical usage levels.
WHMIS Classification (Canada): D2B (toxic materials causing other toxic effects)
Label Elements: Hazardous chemical; comply with hazard communication regulations for labeling
Inventory Status: May require notification under various national chemical inventory laws (consult local authority).
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