Product Name: R-3-chloro-1,2-propanediol
Synonyms: 3-Chloropropane-1,2-diol, α-Chlorohydrin
Chemical Formula: C3H7ClO2
Molecular Weight: 110.54 g/mol
CAS Number: 96-24-2
Recommended Use: Laboratory chemicals, organic synthesis intermediate
Supplier: Refer to product label for manufacturer details
Contact Information: Emergency phone numbers provided by manufacturer; consult local poison control for immediate medical support
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation), Skin Irritation, Eye Irritation, Carcinogenicity, Mutagenicity
Signal Word: Danger
Hazard Statements: Toxic if swallowed, causes skin and eye irritation, may cause genetic defects, suspected of causing cancer, harmful if inhaled
Pictograms: Skull and crossbones, exclamation mark, health hazard
Precautionary Statements: Avoid all unnecessary exposure, use protective gear, do not breathe dust or vapor, wash hands thoroughly after handling
Most Important Hazards: High toxicity, potential reproductive toxin, risk to aquatic and terrestrial environments
Chemical Name: R-3-chloro-1,2-propanediol
Concentration: 98-100%
CAS Number: 96-24-2
Impurities/Additives: Usually free of stabilizers, but trace residual solvents may be present from manufacturing
Inhalation: Move person to fresh air, monitor for breathing difficulties, assess for cough and respiratory distress, seek medical attention as needed
Skin Contact: Remove contaminated clothing, wash affected area thoroughly with soap and water, contact a physician if irritation or burns occur
Eye Contact: Rinse immediately with plenty of water, keep eyelids open, remove contact lenses, continue rinsing for at least 15 minutes, seek prompt ophthalmic evaluation
Ingestion: Rinse mouth, do not induce vomiting, give water only if person is conscious, seek emergency medical help immediately
Important Symptoms: Burning sensation, cough, headache, nausea, abdominal pain; symptoms may be delayed after exposure
Immediate Medical Attention Required: Yes, particularly with ingestion, inhalation, or significant skin/eye contact
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray
Unsuitable Media: High-pressure water jet can spread splash hazards
Specific Hazards: Flammable vapors, formation of toxic gases (HCl, carbon monoxide, carbon dioxide) from thermal decomposition
Protective Equipment: Wear self-contained breathing apparatus, full protective suit, protective gloves and boots
Special Procedures: Remove containers from fire area if safe, prevent runoff into drains, cool fire-exposed containers with water spray
Combustion Products: Hydrogen chloride, phosgene, carbon oxides
Personal Precautions: Evacuate area, avoid contact with skin, eyes, and clothing; wear suitable personal protective equipment including gloves, goggles, and protective clothing
Environmental Precautions: Do not allow material to enter sewers, surface water, or groundwater; contain spill using absorbent material
Cleanup Procedures: Ventilate area, absorb with inert materials (sand, earth, vermiculite), collect in suitable container, dispose in accordance with national and local regulations, wash spill area thoroughly
Decontamination: Clean contaminated surfaces with water and soap, avoid direct discharge of residues into the environment
Handling: Use only in well-ventilated areas, avoid breathing vapor or contact with skin and eyes, maintain strict hygiene, use closed systems and appropriate local exhaust
Safe Storage Conditions: Store in original container tightly closed, in a cool, dry, well-ventilated area away from sources of heat, ignition, oxidizers, acids, and base
Incompatibilities: Acids, bases, strong oxidizing agents, reactive metals
Storage Life: Consult batch and container labelling, typically stable in unopened containers for up to two years
Exposure Limits: ACGIH TLV: Not established; recommended occupational exposure limit (REL): 0.005 ppm
Engineering Controls: Provide local exhaust or general ventilation, enclosure of the process, use explosion-proof equipment
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, flame-resistant lab coat, chemical-resistant apron, appropriate respirator for vapor or dust exposure
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing and launder before reuse, prohibit eating or drinking in the work area
Appearance: Colorless or pale-yellow, viscous liquid
Odor: Mild, faintly sweet or chloroform-like odor
Boiling Point: Approximately 213°C (415°F)
Melting Point: -40°C (-40°F)
Flash Point: 122°C (252°F) (closed cup)
Solubility: Miscible with water, soluble in alcohols and ethers
Density: 1.32 g/cm³ at 20°C
Vapor Pressure: 0.013 hPa at 20°C
Partition Coefficient (log Kow): -0.92
Viscosity: Moderate to high viscosity
pH: Neutral (6-8)
Evaporation Rate: Slow
Chemical Stability: Stable under normal conditions, susceptible to hydrolysis in the presence of acids or bases
Possible Hazardous Reactions: Contact with acids, bases, and oxidizers can result in violent decomposition
Conditions to Avoid: Heat, open flame, sources of ignition, contact with incompatible substances
Incompatible Materials: Strong oxidizing agents, acids, alkalis, reactive metals
Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide and dioxide, phosgene
Acute Toxicity: Oral LD50 (rat): 85 mg/kg; Dermal LD50 (rabbit): 482 mg/kg
Inhalation: Harmful and toxic, may cause irritation of respiratory system, pulmonary edema
Skin Corrosion/Irritation: Causes moderate to severe irritation, burns possible upon prolonged contact
Eye Damage/Irritation: Serious risk of burns and long-term damage
Chronic Effects: Probable human carcinogen (IARC 2B), mutagenic in animal studies, possible effects on fertility and fetal development
Routes of Exposure: Inhalation, ingestion, cutaneous, ocular
Target Organ Effects: Liver, kidneys, central nervous system
Symptoms: Stomach pain, headache, dizziness, confusion, skin burns, respiratory distress
Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term adverse effects in aquatic environment
Persistence and Degradability: Moderate biodegradability, but can persist in soils and sediments under certain conditions
Bioaccumulation: Low potential (log Kow < 1)
Mobility in Soil: High mobility due to water solubility
Potential Environmental Impact: Risk to aquatic organisms, potential for groundwater contamination, should be prevented from release into environment
Toxicity Data: LC50 (fish, 96h): 210 mg/L; EC50 (daphnia, 48h): 120 mg/L
Waste Disposal Methods: Incinerate at approved facility, avoid landfill disposal, follow all federal and local regulations, contact hazardous waste handler for guidance
Contaminated Packaging: Rinse with suitable solvent, dispose as hazardous waste, do not reuse packaging
Precautions: Do not release to environment, prevent contact with ground or surface waters
Regulatory Waste Number: Check local/national listings, typically regulated as toxic hazardous waste
UN Number: 2810
Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (contains R-3-chloro-1,2-propanediol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels Required: Toxic
Marine Pollutant: Yes
Special Transport Precautions: Secure tightly-sealed containers, segregate from oxidizers and foodstuffs, avoid all contact during loading/unloading
TSCA: Listed in the United States Toxic Substances Control Act Inventory
OSHA Hazard Category: Toxic, irritant, possible carcinogen
SARA Title III: Subject to reporting under Sections 302, 313
REACH (EU): Registered, subject to SVHC (Substances of Very High Concern) review
WHMIS (Canada): Class D1A (Very toxic), D2A (Carcinogenic/mutagenic)
California Proposition 65: Listed as a chemical known to the State of California to cause cancer
Other National/International Listings: IARC Group 2B, NTP Reasonably Anticipated Carcinogen
Labeling Requirements: Use appropriate GHS and country-specific precautionary labels on all containers
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