Product Name: (R)-3-chloro-1,2-propanediol acetonide
Synonyms: (R)-3-chloro-1,2-propanediol 1,2-isopropylidene acetal
Chemical Formula: C6H11ClO2
CAS Number: 222865-08-7
Recommended Uses: Laboratory synthesis, intermediate for pharmaceuticals, research & development
Supplier: [Company’s address and contact information]
Hazard Classification: Acute Toxicity (Oral, Dermal), Eye Irritation, Skin Irritation, Specific Target Organ Toxicity (single exposure)
Signal Word: Danger
Hazard Statements: Harmful if swallowed, toxic in contact with skin, causes severe eye damage, may cause respiratory irritation
Pictograms: Skull and crossbones, exclamation mark, corrosion
Precautionary Statements: Avoid breathing dust/fume/gas/mist/vapors/spray. Wash hands and face thoroughly after handling. Wear protective gloves, protective clothing, and eye/face protection. Use only outdoors or in a well-ventilated area.
Chemical Name: (R)-3-chloro-1,2-propanediol acetonide
Concentration: >98%
CAS Number: 222865-08-7
Impurities and Stabilizing Additives: Contains trace levels of unreacted reactants and related acetonide derivatives (<2%)
Inhalation: Move to fresh air. Keep at rest in a position comfortable for breathing. Call a poison center or doctor if you feel unwell.
Skin Contact: Remove contaminated clothing. Rinse skin immediately with plenty of soap and water. Seek medical advice if irritation or symptoms develop.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Get immediate medical attention.
Ingestion: Rinse mouth. Do not induce vomiting. Seek medical help right away. Never give anything by mouth to an unconscious person.
Most important symptoms/effects: Irritation of skin, eyes, nose and respiratory tract; possible gastrointestinal distress.
Suitable Extinguishing Media: Carbon dioxide, foam, dry powder, or water spray. Use agent for surrounding fire.
Specific Hazards: Releases toxic fumes of hydrogen chloride and carbon oxides under fire conditions. Container may rupture in the heat of a fire.
Protective Equipment and Precautions: Firefighters need full protective gear including self-contained breathing apparatus. Remove containers from fire zone if possible.
Special Firefighting Procedures: Cool containers with flooding quantities of water until well after fire is out. Prevent runoff from firefighting from entering drains or water courses.
Personal Precautions: Wear chemical splash goggles, lab coat, impervious gloves, and respiratory protection if needed. Avoid breathing vapor, mist, or dust.
Methods for Containment and Cleaning Up: Evacuate area. Absorb spills with inert material. Place in chemical waste container. Ventilate area and wash spill site after material pickup is complete.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Avoid release to environment. Do not allow to enter drains, surface, or groundwater.
Handling: Work in a well-ventilated space. Avoid contact with skin, eyes, and clothing. Do not breathe dust, vapor, or mist. Wash thoroughly after handling. Keep away from heat, sparks, and flames.
Storage: Store in tightly closed container in a cool, dry, well-ventilated area. Protect from light, incompatible materials (strong oxidizers, acids, and bases), and moisture. Prevent static electricity buildup. Segregate from foodstuffs and animal feed.
Exposure Limits: No established exposure limits for this compound. Use local exhaust ventilation to keep airborne concentrations below recommended exposure limits for similar chemicals.
Engineering Controls: Work in chemical fume hood. Use explosion-proof equipment and electrical systems.
Personal Protection: Wear chemical-resistant gloves, safety glasses or goggles, lab coat, and appropriate respiratory protection if airborne exposure is possible. Provide emergency eyewash and safety shower stations in the immediate work area.
Appearance: Colorless to pale yellow liquid
Odor: Slight chemical odor
Odor Threshold: Not established
pH: Not available
Melting Point: Not available
Boiling Point: 195-197 °C (estimated)
Flash Point: >70 °C (closed cup)
Evaporation Rate: Not determined
Vapor Pressure: Not determined
Vapor Density: Not determined
Relative Density: 1.24 (estimated)
Solubility: Slightly soluble in water, soluble in common organic solvents like ethanol, ether, and acetone
Partition Coefficient (log Kow): Not determined
Autoignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Not determined
Reactivity: Reacts vigorously with strong oxidizing agents, acids, and bases.
Chemical Stability: Stable under normal conditions, if kept in tightly closed container and stored in cool, dry, and ventilated area.
Hazardous Reactions: May react upon contact with moisture to release hydrochloric acid vapors.
Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide.
Conditions to Avoid: Excess moisture, heat, flames, sparks, incompatible materials.
Routes of Exposure: Inhalation, ingestion, skin and eye contact.
Acute Toxicity: Oral LD50 (rat): no reliable data, based on structural analogs, potentially toxic at low doses. Dermal LD50 (rabbit): no specific data, treat as harmful in contact with skin.
Skin Corrosion/Irritation: Causes irritation; redness, pain, or burns.
Serious Eye Damage/Eye Irritation: Causes serious irritation and possible permanent damage.
Respiratory or Skin Sensitization: Not fully evaluated, may cause allergic reaction in sensitive individuals.
Germ Cell Mutagenicity: Not classified.
Carcinogenicity: No data available on carcinogenic properties of this specific compound.
Reproductive Toxicity: Not evaluated; treat as potentially hazardous.
Specific Target Organ Toxicity: May affect liver, kidneys, central nervous system with repeat or severe exposures.
Symptoms: Cough, headache, dizziness, nausea, abdominal cramps, dermatitis.
Ecotoxicity: Harmful to aquatic life. May cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Does not break down rapidly. Estimated to be persistent in the environment.
Bioaccumulative Potential: Potential for bioaccumulation based on chemical structure.
Mobility in Soil: Likely mobile and could leach into groundwater.
Other Adverse Effects: No information on ozone depletion, global warming potential, or photochemical ozone creation potential. Avoid environmental release.
Disposal Methods: Dispose of waste according to local, regional, national, and international regulations. Do not mix with household waste. Send to an approved chemical disposal facility.
Container Disposal: Rinse thoroughly before discarding or recycling. Containers may retain product residues; treat empty containers with care.
Special Precautions: Avoid disposal to drains, sewers, or natural environment.
UN Number: Not assigned (consult with shipper and local authorities for updates)
UN Proper Shipping Name: Chemical, n.o.s. (contains chloro-1,2-propanediol acetonide)
Transport Hazard Class: 6.1 (toxic substances, if required for similar chemicals)
Packing Group: III (subject to transport and regulatory updates)
Marine Pollutant: Not classified; avoid release to waterways.
Special Precautions for Transport: Protect from physical damage and comply with all transport regulations applicable to hazardous laboratory chemicals.
OSHA Status: Not specifically listed, treat as hazardous according to OSHA Lab Standard.
EPA Status: Not listed on TSCA Inventory, subject to reporting under TSCA if used in manufacturing.
SARA Title III Sections 302/311/312/313: Not listed.
EU Regulation: Not classified under REACH, if imported/exported in significant quantity, registration may be required.
Other Regulations: Subject to import/export controls in some countries. Users must review all local laws and standards before handling.
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