Product Name: (R)-(-)-2-Chloro-2-propanol
Chemical Formula: C3H7ClO
Molecular Weight: 94.54 g/mol
Synonyms: (R)-2-Chloropropan-2-ol; (R)-2-Chloroisopropanol
CAS Number: 563-47-3
Recommended Use: Laboratory chemicals, chemical synthesis
Manufacturer: Chemical suppliers in academic and industry settings
Emergency Contact: Poison Control (General US: 1-800-222-1222), local emergency responder
Hazard Classification: Acute Toxicity (Oral, Dermal, Inhalation - Category 3)
Signal Word: Danger
Hazard Statements: Harmful if swallowed, in contact with skin, or if inhaled. Causes serious eye irritation. May cause drowsiness or dizziness. Toxic to aquatic life.
Precautionary Statements: Avoid breathing dust, vapors, or spray. Wash hands and exposed skin thoroughly after handling. Wear protective gloves, protective clothing, eye and face protection. Do not eat, drink, or smoke while using this chemical. Use only outdoors or in a well-ventilated area. Avoid release into the environment.
Chemical Name: (R)-(-)-2-Chloro-2-propanol
CAS Number: 563-47-3
Concentration: 97-100% (neat substance used in most research settings)
Impurities and Stabilizing Additives: Trace residual solvents or process impurities possible; not significant in high purity grades.
General Advice: Move affected person to fresh air. Call a physician right away.
If Inhaled: Remove individual to fresh air and keep comfortable for breathing. Seek medical attention if symptoms (e.g., cough, dizziness, respiratory distress) persist.
In Case of Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. If irritation or redness develops, seek medical advice.
If In Eyes: Rinse immediately with water for at least 15 minutes, keeping eyelids open. Remove contact lenses if present and easy to do. Seek medical help.
If Swallowed: Rinse mouth. Do not induce vomiting unless directed by medical personnel. Seek medical attention immediately. Potential for aspiration into lungs exists.
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray (do not direct water jet directly on burning material)
Specific Hazards: Vapors can form explosive mixtures with air. Combustion may generate toxic and corrosive fumes (hydrogen chloride, phosgene, carbon oxides).
Special Protective Equipment for Firefighters: Wear full protective gear and self-contained breathing apparatus (SCBA). Approach fire from upwind to avoid hazardous vapors and decomposition products.
Fire Fighting Procedures: Use water spray to cool fire-exposed containers. Contain run-off to prevent environmental contamination.
Personal Precautions: Evacuate unnecessary personnel. Ventilate area. Avoid inhalation, skin, and eye contact. Use recommended personal protective equipment.
Environmental Precautions: Prevent entry into drains, surface water, or soil. Notify authorities in case of large spill.
Methods for Containment and Cleaning Up: Absorb spilled liquid using non-combustible absorbent (e.g., sand or vermiculite). Collect and place in appropriate waste container. Ventilate area and wash spill site after removal. Dispose of according to local regulations.
Precautions for Safe Handling: Work under chemical fume hood with adequate air flow. Do not breathe vapor, mist, or spray. Wash hands thoroughly after handling. Avoid contact with skin and eyes.
Conditions for Safe Storage: Keep container tightly closed in a dry, well-ventilated area. Store away from acids, alkalis, oxidizing agents, heat sources, and open flame. Store at controlled room temperature or as specified by supplier. Use corrosion-resistant storage containers.
Incompatible Materials: Strong oxidizers, strong acids or bases, reducing agents, active metals.
Occupational Exposure Limits: No established OSHA, NIOSH, or ACGIH exposure limits specifically for this compound; handle as an acute toxin.
Engineering Controls: Use fume hood or equivalent exhaust ventilation.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, laboratory coat, closed-toe shoes. In poorly ventilated settings, use appropriate respiratory protection.
Hygiene Measures: Remove contaminated clothing and wash thoroughly before reuse. Avoid eating, drinking, or smoking in the work area.
Appearance: Colorless to pale yellow liquid
Odor: Sweet or chloroform-like odor, mild
pH: Not determined (neutral to slightly acidic on contact with water)
Melting Point: -59°C
Boiling Point: 127-130°C
Flash Point: 46°C (closed cup)
Evaporation Rate: No data available
Flammability: Flammable liquid
Vapor Pressure: 13 mm Hg at 25°C
Vapor Density: Heavier than air
Relative Density: 1.17 (Water = 1)
Solubility: Miscible with water, ethanol, diethyl ether, acetone
Partition Coefficient (log Kow): -0.39
Auto-Ignition Temperature: 395°C
Decomposition Temperature: Not established
Viscosity: Not available
Chemical Stability: Stable under recommended storage conditions.
Possible Hazardous Reactions: Reacts with strong oxidizers and acids, producing toxic gases (hydrogen chloride).
Conditions to Avoid: Heat, open flames, sources of ignition, incompatible chemicals.
Incompatible Materials: Oxidizing materials, strong acids and bases, reducing agents.
Hazardous Decomposition Products: Toxic gases such as hydrogen chloride, phosgene, and carbon monoxide can form during combustion or thermal decomposition.
Acute Toxicity (Oral LD50 – rat): 178 mg/kg
Acute Toxicity (Dermal LD50): Data limited, expected to be toxic
Acute Toxicity (Inhalation LC50 – rat): Not established, considered hazardous by inhalation
Potential Health Effects: Causes severe irritation to eyes, skin, and respiratory tract. May depress the central nervous system, resulting in dizziness, headache, drowsiness. Ingestion can damage gastrointestinal and nervous systems.
Symptoms of Overexposure: Burning sensation, coughing, shortness of breath, skin redness, irritation, possible delayed lung damage, nausea, vomiting.
Carcinogenicity: Not classified by IARC, NTP, or OSHA as a carcinogen.
Mutagenicity: Not well studied; use caution.
Repeated Dose Toxicity: Chronic exposure not well-documented; may affect central nervous system, liver, kidneys.
Aquatic Toxicity: Very toxic to aquatic organisms. High possibility of damage in aquatic settings if released untreated.
Persistence and Degradability: Mobile in environment, expected to biodegrade but can persist under low-oxygen conditions.
Bioaccumulative Potential: Low; log Kow suggests little bioaccumulation.
Soil Mobility: High mobility, risk to groundwater.
Other Harmful Effects: Toxic to most microorganisms and can disrupt biological wastewater treatment plants.
Precautions: Prevent chemical release to environment. Use secondary containment systems where possible.
Waste Disposal Methods: Dispose of as hazardous waste following federal, state, or local regulations. Incinerate in permitted facility if possible.
Contaminated Packaging: Triple rinse with water and solvent. Dispose as hazardous waste.
Special Precautions: Prevent liquid from entering sewers or waterways. Use certified chemical disposal contractor.
RCRA Status: Hazardous waste; check classification with authorities.
UN Number: UN 1993
UN Proper Shipping Name: Flammable Liquid, N.O.S. (contains (R)-(-)-2-Chloro-2-propanol)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Environmental Hazards: Marine pollutant (dangerous to aquatic environment)
Special Precautions: Secure tightly sealed packaging, keep away from food and animal feed, provide clear hazard labeling.
Transport by Air (IATA): Subject to relevant regulations for flammable liquids.
OSHA Status: Hazardous chemical. Acute toxicity and eye irritant classification.
TSCA (US) Inventory: Listed
SARA Section 313: Not specifically listed
REACH (Europe): Pre-registered, subject to annual tonnage notification if imported or manufactured in EU
DSL (Canada): Listed
California Proposition 65: Not listed
WHMIS Classification (Canada): Class B2 (Flammable liquid); D1B (Toxic material); D2B (Eye irritant)
Other International Inventories: Consult local regulations, substance generally regulated as hazardous due to flammability and acute toxicity
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