Chemical Name: (R)-(-)-2-Chloro-1-propanol
Synonyms: (R)-(-)-1-Chloro-2-hydroxypropane, (R)-(-)-2-Chloropropanol
CAS Number: 57090-45-6
Product Codes: Often varies by supplier
Recommended Uses: Used as a chiral building block in chemical synthesis, intermediate in pharmaceuticals and agrochemical production
Supplier Information: Listed on shipping documents and manufacturer data
Emergency Phone Number: Typically provided on product label or safety sheet from supplier
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin irritation, eye irritation, specific target organ toxicity
Hazard Statements: Harmful if swallowed or in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Signal Word: Warning
Precautionary Statements: Avoid breathing vapors or dust. Wear protective gloves, clothing, and eye/face protection. Wash thoroughly after handling.
Hazard Symbols: Exclamation mark (irritant)
Routes of Exposure: Skin contact, ingestion, inhalation, eye contact
Potential Health Effects: Irritation to respiratory tract, eyes, skin, mucous membranes; possible central nervous system effects with high exposure
Substance: (R)-(-)-2-Chloro-1-propanol
CAS Number: 57090-45-6
Formula: C3H7ClO
Purity: Typically above 95% for chemical synthesis applications
Impurities: Chlorinated byproducts, trace alcohols (content varies by manufacturer)
Inhalation: Move affected individual to fresh air. Seek medical help if symptoms like coughing, shortness of breath, or dizziness occur.
Skin Contact: Remove contaminated clothing. Wash exposed skin with soap and plenty of water for several minutes. Get medical advice if irritation persists.
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lifting eyelids occasionally. Remove contact lenses if easily possible. Seek prompt medical attention.
Ingestion: Rinse mouth with water. Never give anything by mouth to an unconscious person. Do not induce vomiting; get immediate medical attention.
Most Important Symptoms: Eye and skin irritation, gastrointestinal distress, possible central nervous system effects
Advice for Physician: Treat symptomatically, observation recommended for delayed effects
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Specific Hazards: Vapors may be heavier than air, forming explosive mixtures with air. Combustion can produce toxic gases such as hydrogen chloride, carbon monoxide, and carbon dioxide.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Special Procedures: Cool exposed containers with water spray. Avoid inhaling combustion products.
Hazardous Combustion Products: Hydrogen chloride gas, carbon monoxide, carbon dioxide, potentially irritating aldehydes
Personal Precautions: Evacuate area if large spill occurs. Wear chemical splash goggles, protective gloves, and a lab coat or appropriate personal protective equipment (PPE).
Environmental Precautions: Prevent entry into sewers, soil, or waterways. Alert authorities if product has caused environmental contamination.
Cleanup Methods: Absorb spill with inert material such as sand or earth, then collect and place into a suitable, labeled waste container. Ventilate the area and wash with plenty of water after material pick-up. Dispose of cleanup materials according to regulations.
Additional Advice: Follow all workplace procedures for hazardous material clean-up.
Safe Handling: Use only in well-ventilated areas, preferably in a fume hood. Keep away from heat, sparks, open flame, and hot surfaces. Do not breathe vapors or contact eyes and skin.
Storage Conditions: Store in tightly closed containers. Keep in a cool, dry, well-ventilated area, away from incompatible materials such as strong oxidizers, acids, or alkalis.
Incompatible Materials: Strong acids, alkali metals, oxidizing agents, reducing agents
Hygiene Measures: Wash hands thoroughly after handling. Remove contaminated clothing and wash before reuse.
Specific Storage Requirements: Keep container tightly sealed and properly labeled. Avoid storing with food or drink. Minimize vapor buildup by providing secondary containment.
Occupational Exposure Limits: Not established for this specific compound; minimize exposure as a precaution.
Engineering Controls: Use chemical fume hood, local exhaust, or other engineering controls to maintain airborne levels below recommended exposure limits.
Personal Protective Equipment: Chemical splash goggles, compatible chemical-resistant gloves (e.g., nitrile), lab coat or apron, and in high vapor situations, an approved respirator with multi-gas cartridge.
Hygiene Measures: No eating, drinking, or smoking in areas where the chemical is used. Wash hands before breaks and after handling.
Environmental Exposure Controls: Keep out of drains, surface waters, and soil as a preventive measure.
Appearance: Clear colorless to pale yellow liquid
Odor: Mild alcohol-like
Odor Threshold: Information not defined
pH: Neutral to slightly acidic
Melting Point/Freezing Point: Approx. -65°C
Boiling Point/Range: 130-132°C
Flash Point: Approx. 48°C (closed cup)
Evaporation Rate: Not readily determined
Flammability: Flammable liquid category
Vapor Pressure: Low at room temperature
Vapor Density: Heavier than air
Relative Density: About 1.18 (water = 1)
Solubility: Miscible with water and common organic solvents
Partition Coefficient (log Pow): Not fully characterized
Auto-Ignition Temperature: Greater than 400°C
Decomposition Temperature: Not precisely stated
Viscosity: Not specifically reported
Chemical Stability: Stable under standard temperature and pressure in sealed containers.
Reactivity: Reacts with strong oxidizing agents, acids, alkalis.
Possibility of Hazardous Reactions: Vapors may form explosive mixtures with air. May generate heat with incompatible substances.
Conditions to Avoid: Heat, flames, sources of ignition, excessive moisture, incompatible substances.
Hazardous Decomposition Products: Hydrogen chloride, phosgene (in severe conditions), carbon monoxide, carbon dioxide
Polymerization: Not reported to occur under normal conditions
Acute Toxicity: Oral LD50 (rat): Not fully established, expected in moderate toxicity range. Dermal and inhalation data limited; precautionary approach advised.
Skin Corrosion/Irritation: Causes irritation in contact scenarios; severe or prolonged exposure could cause dermatitis.
Serious Eye Damage/Irritation: Expected to cause moderate to severe irritation.
Respiratory Sensitization: Irritant to respiratory tract upon inhalation.
Skin Sensitization: Rare, but possible with repeated exposure.
Chronic Effects: Information not comprehensive. Possible central nervous system effects at higher exposures.
Mutagenicity, Carcinogenicity, Reproductive Toxicity: Not listed by IARC, NTP, OSHA as carcinogenic; no conclusive testing data.
Target Organs: Eyes, respiratory system, skin, central nervous system (at high exposure)
Ecotoxicity: Not fully evaluated, but small chlorinated alcohols typically show moderate aquatic toxicity.
Persistence and Degradability: Readily biodegradable in the environment; degradation occurs through hydrolysis and microbial action.
Bioaccumulation Potential: Low, due to water solubility and rapid biological breakdown.
Mobility in Soil: Expected to be highly mobile; may leach to groundwater if released.
Other Adverse Effects: Releases to the environment should be minimized. Chronic exposure may affect aquatic organisms.
Disposal Methods: Dispose of as hazardous chemical waste according to local, regional, national, or international regulations. Use licensed waste disposal contractors for significant quantities.
Contaminated Packaging: Dispose of as unused product, ensuring containers are thoroughly rinsed and properly labeled.
Special Precautions: Do not allow product to access drains or natural water bodies. Consult official guidance and chemical laws for local requirements.
Additional Advice: Consider the environmental impact before disposal and select the most responsible disposal technique available.
UN Number: 1992 (if classified as chlorinated alcohol, Flammable liquid, toxic, n.o.s.)
UN Proper Shipping Name: Flammable liquid, toxic, n.o.s. (contains (R)-(-)-2-Chloro-1-propanol)
Transport Hazard Class: 3 (Flammable liquids), Subsidiary risk: 6.1 (Toxic substances)
Packing Group: III (depends on quantity and concentration)
Labeling Requirements: Flammable liquid / Toxic substance as required by regulation
Environmental Hazards: Avoid releasing to environment during transportation. Follow spill prevention guidance.
Special Transport Precautions: Use secure containers, secondary containment, ventilation for large shipments or bulk transport.
Regulatory Status: Subject to IATA, IMDG, DOT shipping rules for hazardous chemicals
Regulations: Subject to chemical control regulations in many countries, including the TSCA Inventory in the USA, REACH in Europe;
Labeling Requirements: GHS-compliant pictograms, hazard and precautionary statements, supplier identification
Other Regulatory Listings: Not currently listed as a carcinogen or particularly hazardous substance by international agencies
Workplace Safety: Employees handling the material should receive proper chemical safety training per OSHA, local or European directives
Environmental Restrictions: Must comply with national wastewater and air emission standards for chlorinated solvents
Additional Information: Safety data to be updated according to ongoing research and emerging regulations as information on long-term effects or environmental impact grows
Providing high-quality chemical products and logistics solutions for global trade partners.
