Product Name: (R)-1-Chloro-2-Propanol 98+%
Synonyms: (R)-2-Chloro-1-propanol, (R)-1-Chloropropan-2-ol
CAS Number: 42142-52-9
Recommended Use: Laboratory reagent, chemical synthesis
Manufacturer/Supplier: Refer to safety department for details
Emergency Contact: Chemtrec: +1-800-424-9300
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritation, specific target organ toxicity
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin, or if inhaled. Causes skin irritation. Causes serious eye irritation. Harmful to aquatic life.
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Avoid breathing dust, fumes, mist or vapors. Use only outdoors or in well-ventilated areas. Wear protective gloves, clothing, and eye protection.
Chemical Name: (R)-1-Chloro-2-propanol
Concentration: ≥98%
CAS Number: 42142-52-9
Impurities/Additives: Minimal, specific mixture or trace impurities not relevant for standard laboratory handling at listed concentration.
Inhalation: Move exposed person to fresh air immediately. Keep person at rest. Seek medical attention if symptoms appear, such as coughing, dizziness, or difficulty breathing.
Skin Contact: Remove contaminated clothing and thoroughly wash skin with plenty of water and mild soap for at least 15 minutes. Call a physician if irritation persists.
Eye Contact: Flush eyes with running water for several minutes, lifting eyelids if needed. Contact an eye specialist if irritation does not ease.
Ingestion: Rinse mouth with water only if victim is fully conscious. Do not induce vomiting. Immediate medical attention is necessary.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam.
Specific Hazards: Releases toxic or irritating vapors of hydrogen chloride and phosgene under fire conditions.
Protective Equipment: Full protective clothing and self-contained breathing apparatus are essential for firefighters.
Special Procedures: Cool exposed containers with water spray to prevent pressure buildup or eruption.
Personal Precautions: Evacuate unprotected personnel. Ensure proper ventilation. Prevent inhalation and contact with skin and eyes using personal protective equipment.
Environmental Protection: Avoid discharge to drains, water sources, or soil. Contain spillage using inert absorbents such as sand or vermiculite.
Clean-up Methods: Absorb liquid with inert material and collect in suitable containers for disposal. Clean contaminated area thoroughly with water and detergent.
Handling: Use in fume hood or well-ventilated place. Avoid direct contact with liquid or vapor. Prevent any source of ignition.
Storage: Store in tightly closed, original container in a cool, dry, well-ventilated area that is chemically resistant. Keep away from incompatible materials such as strong oxidizers and acids.
Other Precautions: Keep away from food and beverages. Ensure storage area has spill containment and emergency washing facilities accessible.
Engineering Controls: Use local exhaust ventilation. Fume hood is advised for laboratory operations.
Respiratory Protection: Wear approved respirator if ventilation is insufficient.
Hand Protection: Protective gloves resistant to chemicals such as nitrile.
Eye Protection: Chemical safety goggles and a face shield if splashes are likely.
Skin/Body Protection: Laboratory coat, long sleeves, and closed shoes. Emergency shower and eyewash stations recommended in work area.
Hygiene Measures: Wash hands thoroughly after handling. Do not eat, drink, or smoke during use.
Appearance: Colorless to slightly yellow liquid
Odor: Characteristic, faintly sweet and chemical
Odor Threshold: Data not available
pH: Not applicable
Melting Point: -33°C (approximate)
Boiling Point: 153°C (at 760 mmHg)
Flash Point: 53°C (closed cup, approximate)
Evaporation Rate: No data
Flammability: Combustible liquid
Upper/Lower Flammability Limits: No data available
Vapor Pressure: 1.3 hPa at 20°C
Vapor Density: No data
Relative Density: 1.17 g/cm³ at 20°C
Solubility: Miscible with water
Partition Coefficient (n-octanol/water): No data
Auto-Ignition Temperature: 355°C (estimate)
Decomposition Temperature: No data
Viscosity: No data available
Chemical Stability: Stable under proper storage and handling conditions.
Reactivity: No hazardous reactivity expected under recommended use.
Possible Hazardous Reactions: May react with strong bases, acids, alkali metals, oxidizing agents.
Conditions to Avoid: Heat, open flames, sparks, exposure to moisture.
Incompatible Materials: Strong oxidizing agents, acids, alkali metals.
Hazardous Decomposition Products: Releases hydrogen chloride, phosgene, and carbon oxides upon decomposition.
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion.
Acute Toxicity: Toxic effects appear rapidly after ingestion, inhalation, or contact. Animal data shows LD50 (oral, rat) approximately 200-300 mg/kg.
Skin Corrosion/Irritation: Irritates skin and mucous membranes.
Serious Eye Damage/Irritation: Serious irritation, potential for eye injury on contact.
Respiratory or Skin Sensitization: No data indicating specific sensitization.
Other Effects: May affect central nervous system, liver, kidneys at high exposure levels.
Chronic Effects: No comprehensive studies on repeated exposure. Assume potential for organ toxicity at repeated high exposures.
Carcinogenicity/Mutagenicity: Insufficient data for assessment; handle with care and minimize all exposure.
Ecotoxicity: Harmful to aquatic life with long lasting effects. Fish and invertebrate toxicity data limited but expect environmental hazard in concentrated spills.
Persistence and Degradability: Biodegradation data is limited. Compound may persist in soil and water due to halogenated structure.
Bioaccumulative Potential: Low-to-moderate potential due to some water solubility, but no clear evidence.
Mobility in Soil: Expected to migrate to groundwater due to water solubility.
Other Adverse Effects: Avoid release into the environment. Do not allow product to enter waterways, drains, or soil.
Product Disposal: Dispose as hazardous chemical waste through licensed disposal contractor. Do not mix with domestic waste or pour down the drain.
Contaminated Containers: Rinse only if required by regulation, then dispose of in accordance with local, regional, and national laws.
Disposal Methods: Incineration in chemical incinerator equipped with afterburner and scrubber is preferred. Consult local waste authorities for recommended procedures.
UN Number: 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (Contains (R)-1-Chloro-2-propanol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Marine Pollutant: Not classified as marine pollutant (verify local requirements).
Special Precautions: Use leak-proof containers. Follow hazard communication requirements during transport.
Label Requirements: Toxic substance, keep away from unauthorized personnel.
TSCA: Listed in the United States Toxic Substances Control Act inventory.
REACH Status: Not fully registered; check current status.
DSL/NDSL (Canada): Consult latest listings.
OSHA Hazardous Chemical: Regulated under OSHA Hazard Communication Standard.
SARA 313: Does not appear on the Section 313 list, but reporting may be necessary depending on use and quantity.
California Prop 65: Not specifically listed, but handle with control due to toxicological profile.
Other Regulations: Follow all local, regional, and national laws regarding chemical safety, storage, and handling.
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