Product Name: Quinidine Gluconate and Quinidine Sulfate
Chemical Family: Alkaloid, Antiarrhythmic Agent
CAS Numbers: 6119-70-6 (Quinidine Gluconate), 50-54-4 (Quinidine Sulfate)
Synonyms: Cinchona alkaloid derivative, Gluconic acid salt
Intended Use: Pharmaceutical active ingredient for treatment of cardiac arrhythmias and malaria
Manufacturer: [Company information as per MSDS requirements]
Emergency Contact: [Local poison center, manufacturer emergency phone number]
Hazard Class: Acute toxicity (oral, dermal, inhalation), Specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled; risk of serious cardiac and neurological effects
Pictograms: Exclamation mark, Health Hazard
Possible Symptoms: Headache, dizziness, nausea, cardiac arrhythmias, convulsions
Routes of Exposure: Ingestion, inhalation, skin, eye
Chronic Effects: Prolonged exposure may lead to liver and kidney dysfunction, hearing loss, visual disturbance
Quinidine Gluconate: 60-99%
Quinidine Sulfate: 60-99%
Excipients/Inert Components: May contain small quantities of residual solvents or binders (as per manufacturing process)
Impurities: Specified per batch certificate, typically less than 1% total
Inhalation: Move to fresh air, provide oxygen if breathing is difficult, seek medical attention for symptoms
Skin Contact: Remove contaminated clothing, wash skin with soap and water, medical evaluation for irritation or allergic response
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, consult ophthalmologist for persistent irritation
Ingestion: Do not induce vomiting, rinse mouth, get medical help immediately, monitor for cardiac symptoms
Advice to Physician: Treat supportively, monitor ECG and vital signs, consider activated charcoal for large exposures
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Media: None known, avoid high-pressure water stream
Special Hazards: Product may emit toxic fumes (carbon oxides, nitrogen oxides, sulfur oxides) under fire
Protective Equipment: Firefighters must wear self-contained breathing apparatus and full protective gear
Thermal Decomposition: Releases hazardous gases, risk of exposure to toxic compounds if inhaled
Personal Precautions: Wear chemical resistant gloves, safety glasses, lab coat, use respirator if dust forms
Environmental Precautions: Do not allow product to enter waterways, drains, or soil
Clean Up Methods: Sweep up or vacuum, use wet methods to minimize dust, transfer to properly labeled waste container
Decontamination: Wash area with water and detergent, ventilate the area
Disposal: Collect residues and contaminated absorbent for approved chemical waste disposal
Handling: Use in a controlled, ventilated setting, avoid inhalation or direct contact, prevent ingestion, use dedicated lab equipment
Storage: Store in tightly closed containers in a cool, dry, well-ventilated area
Incompatibilities: Acidic and basic substances, oxidizers
Segregation: Keep away from food, beverages, animal feed
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke during use
Exposure Limits: Not established for active ingredient; minimize exposure using good laboratory practices
Engineering Controls: Use enclosures, local exhaust ventilation, HEPA-filtered air handling
Personal Protective Equipment: Nitrile gloves, splash-proof goggles, lab coat, respirators (if airborne dust present)
Environmental Controls: Prevent release into the environment through proper waste management
Appearance: Quinidine Gluconate: white to off-white crystalline powder; Quinidine Sulfate: white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: ~6–7 (aqueous solution)
Melting Point: ~220–240°C (decomposition)
Boiling Point: Not volatile
Solubility: Quinidine Gluconate: soluble in water, Quinidine Sulfate: slightly soluble in water
Vapor Pressure: Not applicable
Relative Density: Approx. 1.3 g/cm³
Partition Coefficient (log Kow): ~2.3 for quinidine component
Explosive Limits: Not available
Auto-Ignition Temperature: Data not available
Chemical Stability: Stable under standard conditions of storage and use
Reactivity: No significant reactivity with most substances under normal conditions
Conditions to Avoid: Excessive heat, moisture, direct sunlight
Incompatible Materials: Strong acids, oxidizers, alkalis
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, sulfur oxides
Polymerization: Does not occur
Acute Toxicity: LD50 oral (rat): 641 mg/kg (quinidine sulfate), potentially toxic by ingestion in humans at therapeutic or higher doses
Skin Corrosivity/Irritation: May cause mild skin irritation with prolonged contact
Eye Damage/Irritation: May cause redness, irritation, discomfort
Respiratory Sensitization: Dust inhalation can cause irritation
Chronic Toxicity: Cardiotoxicity, hepatotoxicity, nephrotoxicity after prolonged or repeated exposure
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No well-established information; caution advised for pregnant or breastfeeding individuals
Other Effects: Quinidine can cause cinchonism (headache, tinnitus, blurred vision)
Ecotoxicity: Limited data available; may be toxic to aquatic life with long lasting effects
Persistence and Degradability: Partially biodegradable in environment, but persistent in sediment
Bioaccumulation: Potential for moderate bioaccumulation based on log Kow values
Mobility in Soil: Low to moderate; some potential for groundwater contamination
Other Adverse Effects: No ozone depletion potential; avoid environmental discharge
Waste Disposal Methods: Dispose of via licensed chemical waste contractor, follow local, regional, and national regulations
Disposal of Packaging: Rinse empty containers with water, return to hazardous waste facility or incinerate
Precautions: Do not dispose with regular municipal waste, avoid release to surface water or soil
UN Number: Not classified as hazardous for transport in most jurisdictions
Proper Shipping Name: Not regulated
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: Not a marine pollutant under general conditions—minimize exposure risk
Special Transport Precautions: Keep tightly sealed during transport, prevent spillage or emission of dust
OSHA: Not specifically regulated
TSCA: Listed
EU (REACH): Not registered for widespread commercial use
WHMIS (Canada): Pharmaceutical substances exempt
Other Provisions: Subject to pharmaceutical controls under FDA/EMA standards, personal protection required for occupational exposure, reporting requirements may apply for major spills
Providing high-quality chemical products and logistics solutions for global trade partners.
