Product Name: Propylene Glycol Monomethyl Ether Acetate
Common Synonyms: 1-Methoxy-2-propyl acetate, PMA, PGMEA
Chemical Formula: C6H12O3
CAS Number: 108-65-6
Recommended Uses: Solvent in paints, coatings, inks, cleaners, adhesives
Supplier Information: Manufacturer and distributor addresses, emergency phone numbers, tech support contacts
GHS Classification: Flammable Liquids (Category 3), Eye Irritant (Category 2A), Specific Target Organ Toxicity – Single Exposure (Category 3)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Causes serious eye irritation. May cause drowsiness or dizziness.
Pictograms: Flame, exclamation mark
Precautionary Statements: Avoid breathing vapors. Wash skin thoroughly after handling. Use only outdoors or in well-ventilated areas. Keep away from heat, sparks, open flames, or hot surfaces. No smoking.
Chemical Name: Propylene Glycol Monomethyl Ether Acetate
Concentration: More than 99% by weight
CAS Number: 108-65-6
Impurities and Stabilizing Additives: Typical product forms contain no significant impurities contributing to hazard classification
Inhalation: Move person to fresh air immediately. Seek medical attention for symptoms like headache, dizziness, or shortness of breath. If breathing stops, provide artificial respiration.
Skin Contact: Wash thoroughly with soap and water. Remove contaminated clothing. Call physician if irritation develops.
Eye Contact: Flush eyes for at least 15 minutes with running water. Remove contact lenses if present. Seek medical care if irritation persists.
Ingestion: Rinse mouth with water, avoid inducing vomiting except under medical advice. Seek immediate medical help.
Notes for Physician: Treat symptoms, monitor for respiratory and central nervous system depression.
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide. Water spray for cooling exposed containers.
Unsuitable Media: Direct water jet may spread fire.
Specific Hazards: Vapors may form explosive mixtures with air. Thermal decomposition can generate carbon oxides.
Protective Equipment: Full protective clothing, self-contained breathing apparatus.
Firefighting Instructions: Evacuate area. Use water spray to cool containers. Prevent run-off from entering drains or waterways.
Personal Precautions: Eliminate ignition sources. Ventilate area. Wear chemical-resistant gloves, goggles, respirator if exposure possible.
Environmental Precautions: Prevent entry into drains, groundwater, or surface water. Inform authorities if significant spill reaches environment.
Methods for Cleanup: Contain spill with inert absorbent (sand, vermiculite), collect in containers for disposal. Wash contaminated area with water. Dispose in accordance with regulatory requirements.
Safe Handling: Use in well-ventilated areas. Ground and bond containers when transferring. Avoid contact with eyes, skin, and clothing.
Storage Requirements: Store in tightly closed original containers. Keep in a cool, dry, well-ventilated area, away from ignition sources, oxidizers, acids, alkalis. Protect from direct sunlight and temperature extremes. Label containers clearly.
Incompatible Materials: Strong acids, strong bases, strong oxidizers
Occupational Exposure Limits: ACGIH TLV 50 ppm (TWA), NIOSH REL 100 ppm (TWA), OSHA PEL 100 ppm (TWA)
Engineering Controls: Local exhaust ventilation, process enclosures, eye wash stations, safety showers.
Personal Protective Equipment: Chemical safety goggles, gloves (butyl rubber or nitrile), long-sleeved clothing, respirators approved for organic vapors if needed. Prevent accidental exposure by following established safe practices.
Appearance: Clear, colorless liquid
Odor: Mild ether-like odor
Odor Threshold: Approx 5 ppm
pH: Not applicable (neutral liquid)
Melting Point: -48°C
Boiling Point: 145°C
Flash Point: 45°C (closed cup)
Evaporation Rate: 0.35 (n-butyl acetate = 1)
Flammability: Flammable liquid
Upper/Lower Flammability Limits: 1.5% - 7.0% (vol)
Vapor Pressure: 3.7 mmHg at 20°C
Vapor Density: 4.6 (air = 1)
Specific Gravity: 0.965 (water = 1)
Solubility: Miscible with most organic solvents, slightly soluble in water
Partition Coefficient: Log Kow 0.43
Autoignition Temperature: 315°C
Decomposition Temperature: Not determined
Viscosity: 1.2 mPa·s
Chemical Stability: Stable under normal temperatures and pressures
Possibility of Hazardous Reactions: Reacts with strong oxidizers, may form peroxides with prolonged storage
Conditions to Avoid: Excessive heat, open flames, sparks, incompatibles
Incompatible Materials: Strong acids, strong bases, strong oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, irritating fumes
Acute Toxicity (Oral): LD50 (rat) > 5,000 mg/kg
Acute Toxicity (Inhalation): LC50 (rat, 4h) > 5,500 mg/m³
Skin Irritation: Mild to moderate, possible dermatitis with prolonged exposure
Eye Irritation: Causes noticeable irritation
Respiratory Effects: Drowsiness, dizziness, headache possible at high concentrations
Chronic Effects: Repeated exposure may cause dryness or cracking of skin
Carcinogenicity: No data indicating carcinogenicity
Mutagenicity: Not expected to be mutagenic
Reproductive Toxicity: No evidence of reproductive harm from available data
Ecotoxicity (Aquatic): LC50 (fish, 96h): 100 – 200 mg/L
Persistence and Degradability: Biodegradable, average aerobic degradation half-life less than 28 days
Bioaccumulative Potential: Low (Log Kow 0.43)
Soil Mobility: High mobility in soil and water due to solubility
Other Adverse Effects: Expected to have low toxicity to aquatic and terrestrial organisms in usual quantities
Disposal Methods: Incinerate at approved facility or recycle if possible. Do not dump into sewers, waterways, or soil.
Waste Codes: Follow local, regional, national, and international regulations for chemical waste.
Contaminated Packaging: Empty containers should be drained, triple rinsed, then recycled or disposed of safely. Label as hazardous if residue remains.
UN Number: UN 3272
Proper Shipping Name: Esters, n.o.s. (Propylene Glycol Monomethyl Ether Acetate)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Labels Required: Flammable liquid
Marine Pollutant: No
Special Transport Precautions: Secure containers, avoid transporting with incompatible substances, keep away from heat and open flames.
OSHA Status: Hazardous chemical as defined by OSHA Hazard Communication Standard
TSCA Inventory: Listed
SARA Title III: Section 311/312 (Hazard Categories: Fire, Immediate Health), not subject to Section 302, 304, or 313 reporting
REACH (EU): Registered substance
WHMIS (Canada): B2 (flammable liquid), D2B (toxic material causing other toxic effects)
Other Local Requirements: Comply with national and regional chemical safety regulations. All containers must have appropriate hazard labeling and documentation.
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