Product Name: Propylene Glycol Monomethyl Ether Acetate
Synonyms: PGMEA, 1-Methoxy-2-propanyl acetate
Chemical Formula: C6H12O3
CAS Number: 108-65-6
Recommended Use: Solvent in coatings, inks, cleaners, electronics
Supplier Information: Manufacturer or importer contact details, including address and emergency phone number
GHS Classification: Flammable Liquids (Category 3), Eye Irritation (Category 2A), Specific Target Organ Toxicity – Single Exposure (Category 3)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Causes serious eye irritation. May cause drowsiness or dizziness.
Pictograms: Flame, exclamation mark
Precautionary Statements: Keep away from ignition sources. Avoid inhalation or skin/eye contact. Use in well-ventilated area. Store locked up.
Chemical Name: Propylene Glycol Monomethyl Ether Acetate
Concentration: ≥ 99%
CAS Number: 108-65-6
Impurities/Additives: Minor amounts of stabilizers or related glycol ethers may be present. Manufacturers provide details if above relevant thresholds for health or safety.
Inhalation: Remove victim to fresh air; seek medical attention if symptoms persist such as headache, drowsiness, or respiratory irritation.
Skin Contact: Wash with soap and water, remove contaminated clothing, seek advice if irritation continues.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if possible, continue rinsing, consult a medical professional.
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical help, provide the product SDS to clinician.
Most Important Symptoms: Irritation, drowsiness, headache, nausea possible with overexposure. Chronic effects uncommon with normal handling.
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, carbon dioxide, water spray (for cooling containers).
Unsuitable Extinguishing Media: High volume water jet (may spread fire).
Special Hazards: Vapors may form explosive mixtures with air. Container rupture possible in fire due to pressure build-up.
Protective Equipment: Full protective gear, self-contained breathing apparatus. Remove containers from fire if safe to do.
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, possibly irritating and/or toxic fumes.
Personal Precautions: Evacuate area, ventilate, avoid breathing vapors, wear protective gear including gloves and goggles.
Environmental Precautions: Prevent migration to drains, sewers, waterways. Notify authorities if contamination occurs.
Methods for Cleanup: Contain and collect with inert absorbent material like sand or vermiculite, place in suitable closed container for disposal, wash spill area thoroughly, use spark-proof tools.
Handling: Use only in well-ventilated areas, ground and bond containers during transfer, avoid contact with skin, eyes, and clothing, keep away from heat, sparks, flames, or hot surfaces.
Storage: Keep container tightly closed in a cool, dry, well-ventilated location away from sources of ignition and incompatible materials such as strong oxidizers or acids, store in original container.
Other Precautions: Maintain good industrial hygiene, wash hands after use, keep out of reach of children, ensure proper labeling and signage in storage areas.
Permissible Exposure Limit (PEL): Accommodates ACGIH TLV: 50 ppm TWA (skin). Check national regulations for workplace limits.
Engineering Controls: Local exhaust ventilation, flame-proof equipment, explosion-proof lighting.
Personal Protective Equipment: Gloves (nitrile or neoprene), chemical safety goggles, flame-retardant clothing, antistatic footwear. In case of insufficient ventilation, use appropriate respirator compliant with local guidelines.
General Hygiene: No eating, drinking, or smoking during use. Separate and wash work clothing before reuse.
Appearance: Colorless liquid
Odor: Slight ether-like aroma
Odor Threshold: 0.2–0.4 ppm
Melting Point: -64°C
Boiling Point: 146°C
Flash Point: 42°C (closed cup)
Evaporation Rate: Slower than ether
Flammability: Flammable liquid
Upper/Lower Flammable Limits: 1.5–8.0 vol%
Vapor Pressure: 4 mmHg at 20°C
Vapor Density: 4.6 (air = 1)
Solubility: Miscible with most organic solvents; slight solubility in water
Partition Coefficient (log Pow): 0.36
Auto-ignition Temperature: 315°C
Decomposition Temperature: >150°C
Viscosity: 0.7 mPa·s (25°C)
Reactivity: Product remains stable under recommended conditions.
Chemical Stability: Stable under normal temperatures and storage settings.
Conditions to Avoid: Heat, flames, sparks, static discharges, direct sunlight.
Incompatible Materials: Strong oxidizing agents, acids, alkalis accelerating hazardous decomposition.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, aldehydes, acids formed during incomplete combustion.
Routes of Exposure: Inhalation, dermal contact, eye contact, ingestion possible if product is mishandled.
Acute Toxicity: Oral LD50 (rat): > 5,000 mg/kg, Dermal LD50 (rabbit): > 5,000 mg/kg, inhalation effects limited above exposure limits.
Skin Irritation: Low hazard, slight irritation possible with prolonged contact.
Eye Irritation: Moderate to strong, redness, pain, tearing possible.
Chronic Toxicity: Not classified as mutagenic, carcinogenic or teratogenic based on animal data.
Sensitization: No evidence expected in standard use cases.
Symptoms: Drowsiness, headache, anesthesia, central nervous system depression with high exposures.
Acute Aquatic Toxicity: Freshwater fish LC50: > 100 mg/L (96h), Daphnia EC50: > 100 mg/L (48h)
Chronic Aquatic Toxicity: Low risk due to rapid biodegradation.
Persistence and Degradability: Readily biodegradable; half-life under 28 days in aquatic test systems.
Bioaccumulation Potential: Unlikely due to low log Pow value.
Soil Mobility: High mobility in soil systems, leaching possible if released in significant quantities
Other Adverse Effects: Not expected to cause long-term harm to aquatic life at environmental concentrations.
Waste Treatment Methods: Collect spillage, incinerate in approved chemical waste facility. Use licensed hazardous waste contractor for removal.
Packaging Disposal: Empty containers scraped/cleaned, recycled or disposed of as hazardous material, do not reuse.
Precautions: Do not release to sewers or environment. Ensure local, regional, and national waste management guidelines followed.
Special Considerations: Consult regulatory agencies or manufacturer for specific instructions.
UN Number: UN 3272
UN Proper Shipping Name: Esters, n.o.s. (Propylene Glycol Monomethyl Ether Acetate)
Transport Hazard Class: 3 (Flammable Liquids)
Packing Group: III
Label: Flammable liquid
Environmental Hazards: Non-environmentally hazardous for transport
Special Precautions: Use appropriate containers and labeling, ensure documentation accompanies each shipment, segregate from incompatible goods.
OSHA: Hazardous Chemical by OSHA HazCom Standard
SARA Title III: Not listed as extremely hazardous, but subject to reporting above local thresholds
TSCA: Listed on US Toxic Substances Control Act inventory
REACH Registration: Registered in EU, usages and safety assessed
Other International Inventories: Included in AICS (Australia), DSL (Canada), ENCS (Japan), EINECS/ELINCS (EU), PICCS (Philippines), KECL (Korea), NZIoC (New Zealand)
Label Elements: Comply with GHS requirements for hazard communication at workplace and in transport.
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