Product Name: Propylene Glycol Monomethyl Ether Acetate
Chemical Formula: C6H12O3
Other Names: 1-Methoxy-2-propyl acetate, PGMEA
CAS Number: 108-65-6
Recommended Use: Industrial solvent for coatings, inks, cleaners, and adhesives
Manufacturer Contact: Emergency contact information, technical support number, and mailing address associated with the supplier and/or importer
GHS Classification: Flammable liquids – Category 3, Eye irritation – Category 2A, Specific target organ toxicity (single exposure) – Category 3
Pictograms: Flame, Exclamation mark
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Causes serious eye irritation. May cause drowsiness or dizziness.
Precautionary Statements: Keep away from heat, sparks, open flames. Wear protective gloves and eye protection. Wash exposed skin thoroughly after handling. Use explosion-proof electrical equipment. Use only outdoors or in a well-ventilated area to prevent inhalation risk.
Other Hazards: Vapors heavier than air, can travel to ignition source and flash back, inhalation risk in poorly ventilated spaces
Chemical Name: Propylene Glycol Monomethyl Ether Acetate
Concentration: >99% by weight
Impurities: Traces of propylene glycol monomethyl ether possible (less than 1%)
Stabilizers: Not intentionally added
Inhalation: Remove person to fresh air. Provide artificial respiration if not breathing. Seek medical attention if symptoms persist such as headache, nausea, or drowsiness.
Skin Contact: Remove contaminated clothing. Rinse skin thoroughly with plenty of water for at least 15 minutes. Seek medical care if irritation or redness persists.
Eye Contact: Rinse eyes cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing until no evidence of irritation remains.
Ingestion: Rinse mouth with water. Never give anything by mouth to an unconscious person. Seek medical attention. Do not induce vomiting without advice from poison control or medical expert.
Suitable Extinguishing Media: Alcohol-resistant foam, carbon dioxide, dry chemical, water spray
Specific Hazards: Vapors form explosive mixtures with air. Containers exposed to fire can rupture or vent violently.
Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus. Remove containers from fire area if safe.
Unusual Fire/Explosion Hazards: Combustion can produce carbon oxides, irritating fumes. Cool exposed containers with water spray from a safe distance.
Personal Precautions: Evacuate all non-essential personnel. Eliminate sources of ignition. Ventilate area properly. Wear appropriate personal protective equipment such as gloves, goggles, and respiratory protection.
Spill Response: Contain and absorb spill with non-combustible, inert materials such as sand or earth. Prevent entry into drains, surface water, or soil. Store collected material in suitable, sealed chemical waste containers.
Environmental Precautions: Prevent further leakage or spillage if safe. Notify appropriate authorities if runoff occurs to waterways or drains. Clean contaminated area thoroughly.
Handling: Use only in well-ventilated areas. Avoid contact with skin and eyes. Avoid inhaling vapors or mist. Ground and bond containers when transferring liquid. Keep container tightly closed when not in use.
Storage: Store in original container protected from direct sunlight in a dry, cool, well-ventilated area away from incompatible materials like strong acids, bases, or oxidizers. Store separately from food or potable water supplies.
Incompatible Materials: Avoid storing near acids, alkalis, and oxidizing materials such as peroxides or nitrates.
Occupational Exposure Limits: OSHA TWA 50 ppm (270 mg/m3), ACGIH TLV 50 ppm (Skin)
Engineering Controls: Use local exhaust ventilation to control exposure at source. Avoid accumulation of vapors by ensuring adequate exhaust.
Personal Protective Equipment (PPE): Chemical-resistant gloves (e.g., nitrile), splash-proof safety goggles, long sleeves, and chemical apron. Use NIOSH-approved respirators for vapor or mist if ventilation is not sufficient.
Hygiene Measures: Wash hands and skin after handling. Remove contaminated clothing before eating or drinking. Do not smoke in work area.
Appearance: Clear, colorless liquid
Odor: Mild ether-like
Odor threshold: Approx. 7 ppm
pH: Not applicable
Melting Point / Freezing Point: -64°C
Boiling Point: 145°C
Flash Point: 45°C (Closed cup)
Evaporation Rate: 0.32 (butyl acetate=1)
Flammability: Flammable liquid
Vapor Pressure: 3.7 mmHg at 20°C
Vapor Density: 4.6 (air=1)
Relative Density: 0.965 at 20°C (water=1)
Solubility: Miscible with water and most organic solvents
Partition Coefficient (n-octanol/water): 0.36 (log Pow)
Auto-Ignition Temperature: 352°C
Viscosity: 0.8 cP at 20°C
Chemical Stability: Stable under recommended storage and handling conditions.
Reactivity: Reacts with strong oxidizers and strong acids.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, and potentially irritating aldehydes.
Polymerization: Will not occur under normal process conditions.
Conditions to Avoid: Heat, sparks, open flame, strong alkalis, and direct sunlight.
Routes of Exposure: Inhalation, skin and eye contact, ingestion.
Acute Toxicity: Oral LD50 (rat) > 5000 mg/kg; Dermal LD50 (rabbit) > 2000 mg/kg.
Symptoms: Eye irritation, headache, dizziness, drowsiness, possible respiratory irritation.
Chronic Effects: No evidence of carcinogenicity or mutagenicity in available data. High vapor concentrations may cause central nervous system effects.
Sensitization: Not known to cause skin sensitization.
Other Data: OSHA, NTP, and IARC do not classify this substance as a known carcinogen.
Ecotoxicity: Toxicity to fish (LC50, 96h): >100 mg/l (Leuciscus idus); Daphnia (EC50, 48h): >100 mg/l.
Persistence and Degradability: Readily biodegradable in the environment according to OECD 301 guideline studies.
Bioaccumulation: Low potential for bioaccumulation (log Pow < 1).
Mobility in Soil: High mobility due to water solubility.
Other Adverse Effects: No known significant effects or critical hazards for ozone depletion or photochemical ozone creation potential.
Waste Treatment Methods: Dispose of contents/container in accordance with local, regional, and national regulations. Incinerate under controlled conditions or deliver to approved hazardous waste facility.
Packages: Containers, even when empty, retain product residue and vapor and should be disposed of as hazardous waste. Do not reuse containers.
Precautions: Prevent any spill or leak from reaching drains, watercourses, and soil. Seek specialized chemical disposal vendors.
UN Number: UN 1993
UN Proper Shipping Name: Flammable Liquid, n.o.s. (Propylene Glycol Monomethyl Ether Acetate)
Transport Hazard Class: 3
Packing Group: III
Label: Flammable liquid
Special Precautions: Ensure containers are properly sealed, labeled, and secured for transport. Emergency response information must be available during transit.
Marine Pollutant: Not classified as a marine pollutant under IMDG Code regulations.
Inventory Status: Listed on TSCA (US), EINECS (EU), DSL (Canada), ENCS (Japan), AICS (Australia), and other major chemical inventories.
Chemical Safety Assessment: Required under REACH as applicable.
SARA Title III: Not a Section 302 extremely hazardous substance. Not a Section 313 toxic chemical.
California Proposition 65: Not listed as a known carcinogen or reproductive toxicant.
Other Regulatory Notes: Follow all applicable workplace, environmental, and transportation safety laws. Training and appropriate documentation for hazardous chemical handling required for workers.
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