Chemical Name: Propylene Glycol Mono-Methyl Ether
Synonyms: 1-Methoxy-2-propanol, PGME, PM
CAS Number: 107-98-2
EC Number: 203-539-1
Formula: C4H10O2
Uses: Industrial solvent, coatings, inks, cleaners
Supplier: Contact manufacturer or distributor for details
Emergency Phone: Refer to regional requirements and local safety office
GHS Classification: Flammable Liquids – Category 3, Eye Irritation – Category 2A, Specific Target Organ Toxicity – Single Exposure, Category 3 (Central nervous system)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Causes serious eye irritation. May cause drowsiness or dizziness.
Precautionary Statements: Keep away from open flame, no smoking. Use explosion-proof electrical equipment. Avoid breathing vapor or mist. Wear protective gloves, eye protection.
Label Elements: Flame, Exclamation mark
Potential Health Effects: Inhalation cough, dizziness, headache; skin and eye contact irritation; high concentrations may affect central nervous system; prolonged exposure may worsen symptoms.
Chemical Composition: Pure substance
Main Constituent: Propylene Glycol Mono-Methyl Ether (≥99%)
CAS Number: 107-98-2
Impurities: Typical technical grade material might contain negligible water or trace by-products but is not classified as hazardous due to impurities.
Inhalation: Move to fresh air. Monitor for symptoms like headache or drowsiness. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing. Wash skin with soap and water. If irritation develops, consult a doctor.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses, continue rinsing. If eye irritation persists, seek professional care.
Ingestion: Rinse mouth. Do not induce vomiting unless directed by medical personnel. Get medical attention if effects develop.
Important Symptoms: Headaches, dizziness, nausea, irritated eyes or skin, difficulty breathing in severe exposures.
Note to Physician: Treat symptomatically, monitor for respiratory or CNS depression if large amounts are inhaled or ingested.
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, CO2, water spray
Unsuitable Media: Direct water jet may spread fire
Hazards: Vapors may form explosive mixtures with air; combustion produces carbon monoxide, carbon dioxide, unburned hydrocarbons
Protective Equipment: Self-contained breathing apparatus, full protective clothing
Special Precautions: Remove containers from fire area if safe. Cool containers exposed to flames with water fog.
Firefighting Guidance: Approach from upwind; prevent runoff from fire control or dilution from entering waterways.
Personal Precautions: Ventilate area. Eliminate sources of ignition. Wear appropriate PPE: chemical-resistant gloves, goggles, protective clothing. Avoid inhalation and contact with skin or eyes.
Environmental Precautions: Prevent further leakage or spillage if safe. Do not let product enter drains, waterways, soil.
Cleanup Methods: Contain spill with inert absorbent (sand, earth, vermiculite). Collect and place in appropriate waste container. Clean contaminated area with water and detergent.
Reporting Requirements: Notify authorities if large spillage pollutes waterways or soil as per local regulations.
Safe Handling: Use only in well-ventilated areas. Keep away from heat, sparks, open flames, hot surfaces. No smoking nearby. Avoid breathing vapor. Use nonsparking tools. Minimize contact with skin and eyes.
Storage Conditions: Store in tightly closed container in cool, dry, well-ventilated place. Keep away from direct sunlight, incompatible substances (strong oxidizers, acids). Store below 30°C/86°F.
Transfer: Ground and bond containers when transferring liquid.
Storage Class: Flammable liquids
Incompatible Materials: Strong acids, strong oxidizers, alkaline materials
Exposure Limits: ACGIH TLV: 50 ppm TWA (skin), OSHA PEL: 100 ppm TWA
Engineering Controls: Local exhaust ventilation recommended for indoor use. Mechanical ventilation or room air exchange as needed.
Personal Protection:
- Eyes: Safety glasses or chemical splash goggles
- Skin: Chemical-resistant gloves (butyl rubber, nitrile recommended), long sleeves
- Respiratory: Use NIOSH-approved respirator if ventilation is insufficient
- General Hygiene: Wash hands before breaks, after handling. Remove contaminated clothing and wash before reuse.
Appearance: Colorless, clear liquid
Odor: Mild, ether-like
Odor Threshold: 1–10 ppm
pH: Not applicable
Melting Point: -96°C (-141°F)
Boiling Point: 120°C (248°F)
Flash Point: 31°C (88°F) (closed cup)
Evaporation Rate: 0.62 (n-butyl acetate = 1)
Flammability: Flammable liquid
LEL/UEL: Lower 1.5%, Upper 13.1% (vol%)
Vapor Pressure: 10 mm Hg @ 20°C
Vapor Density: 3.1 (air = 1)
Specific Gravity: 0.92–0.93 (water = 1)
Water Solubility: Completely miscible
Partition Coefficient (Log Kow): -0.437
Autoignition Temperature: 315°C (599°F)
Decomposition Temp: Not established
Viscosity: 1.7 mPa·s (20°C)
Chemical Stability: Stable under recommended storage conditions
Reactivity: May react with strong oxidizers
Conditions to Avoid: Excess heat, sparks, open flames, incompatible materials
Incompatible Materials: Oxidizing agents, acids, alkali, acid chlorides
Hazardous Decomposition: Produces carbon monoxide, carbon dioxide on combustion
Hazardous Polymerization: Will not occur
Acute Toxicity: Oral LD50 (rat): ~4,016 mg/kg, Dermal LD50 (rabbit): >2,000 mg/kg, Inhalation LC50 (rat): >6,000 ppm (6 hours)
Skin Irritation: Mildly irritating
Eye Irritation: Irritating
Sensitization: Not expected
Chronic Exposure: Extended or repeated exposures may impact lungs, liver, kidneys
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Mutagenicity/Teratogenicity: No evidence found in animal studies at normal occupational exposure levels
Other Effects: High vapor concentrations could lead to CNS depression (drowsiness, dizziness, headache, unconsciousness at very high levels)
Ecotoxicity: Aquatic toxicity is low. Fish LC50 (96h): ~20,800 mg/L (Pimephales promelas), Daphnia EC50 (48h): >1,000 mg/L
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulation Potential: Does not bioaccumulate (log Kow -0.437)
Mobility in Soil: High mobility due to water solubility
Other Adverse Effects: Large releases may deplete oxygen in water and stress aquatic life. Spills may mobilize other contaminants in soil.
Waste Treatment Methods: Dispose via licensed waste contractor. Disposal in accordance with local, regional, national, and international legislation.
Incineration: Approved chemical incinerator with afterburner and scrubber
Container Disposal: Empty containers may retain product vapors; do not reuse. Puncture, triple rinse, and recycle or landfill per local laws.
Environmental Hazards: Do not discharge into sewers or waterways.
UN Number: UN3092
UN Proper Shipping Name: 1-Methoxy-2-propanol (Propylene glycol monomethyl ether)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Labels Required: Flammable liquid
Environmental Hazards: Not considered environmentally hazardous for transport purposes
Special Precautions for User: Keep away from heat and sources of ignition. Ensure containers are upright and tightly sealed.
Safety, Health and Environmental Regulations:
- OSHA: Hazardous chemical, subject to worker right-to-know laws
- TSCA: Listed
- REACH (EU): Registered, complies with applicable restrictions
- SARA (Title III): Not regulated under Section 302/304/313
- California Prop 65: Not listed
- Canada (DSL/NDSL): Listed on Domestic Substances List
- Labelling: Required by GHS for flammability and health risk
Other Information: Observe applicable local, regional, and national safety, health and environmental regulations for handling and use. Always check latest chemical inventories for updates and changes in requirements.
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