Chemical Name: Propylene Glycol 1-Monomethyl Ether 2-Acetate
Synonyms: 1-Methoxy-2-propanol acetate, PGMEA, Propylene glycol methyl ether acetate
CAS Number: 108-65-6
Recommended Use: Solvent in paints, coatings, inks, cleaners
Supplier Details: Company name, address, emergency contact number, and non-emergency phone number
Emergency Telephone: Listed emergency hotline for immediate assistance
Product Code: Internal catalog or product identification number (specific to supplier)
GHS Classification: Flammable liquids (Category 3), Eye irritation (Category 2A)
Label Elements: Flame pictogram, exclamation mark
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor; causes serious eye irritation
Precautionary Statements: Keep away from heat, sparks, open flames; no smoking; wear eye protection; avoid breathing vapors; wash hands thoroughly after handling
Hazard Routes: Inhalation, skin contact, eye contact, ingestion
Possible Health Effects: Short-term exposure may cause eye and respiratory irritation, drowsiness, headache; high vapor concentrations may lead to central nervous system effects; repeated skin exposure could dry or crack the skin
Chronic Exposure Warnings: Prolonged exposure might affect liver and kidneys, though occupational settings commonly fall below limits when controls are in place
Chemical Identity: Propylene glycol 1-monomethyl ether 2-acetate
Concentration: Typically 99% or higher
Impurities: Trace amounts of water, diacetate, and residual starting materials
Component Percentages: PGMEA > 99%, water <1%, other impurities less than 0.1% each
CAS Numbers: PGMEA (108-65-6), minor related compounds can have their own numbers if present
Inhalation: Move person to fresh air immediately; keep comfortable for breathing; contact medical help if symptoms persist
Skin Contact: Remove contaminated clothing; wash skin with plenty of soap and water; consult doctor if persistent irritation develops
Eye Contact: Rinse carefully with water for several minutes; remove contact lenses if easy to do so; rinse for at least 15 minutes and seek medical attention if irritation continues
Ingestion: Do not induce vomiting; rinse mouth with water; seek medical attention right away
Most Important Symptoms: Eye redness, stinging, coughing, shortness of breath, dizziness, nausea, headache
Immediate Medical Attention: Prompt evaluation for large exposures or if symptoms persist, especially for eye exposure or inhalation incidents
Suitable Extinguishing Methods: Dry chemical, foam, carbon dioxide, water spray (for cooling containers only, not for direct extinguishing of liquid)
Unsuitable Extinguishing Methods: Direct water jet may spread fire
Hazards During Fire: Vapors heavier than air, may travel to sources of ignition; produces hazardous combustion products such as formaldehyde, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Self-contained breathing apparatus (SCBA), full protective suit
Special Fire Procedures: Remove containers from area if safe; cool surviving containers with water spray; prevent runoff from entering drains or environment
Flash Point: Typically around 42°C to 45°C (closed cup)
Personal Precautions: Remove ignition sources; ventilate area thoroughly; avoid breathing vapors or contact with skin and eyes; use personal protective equipment
Environmental Precautions: Prevent further leakage or spillage if safe; do not discharge into drains, watercourses, or soil
Containment: Dike the spill with inert absorbent material (sand, earth, vermiculite); do not use sawdust or combustible materials
Cleanup Method: Collect absorbed material in closed, suitable containers for disposal; wash spill area thoroughly after pick-up
Emergency Procedures: Isolate hazard area; keep unnecessary personnel away; inform authorities if large amounts released
Handling: Use only with adequate ventilation; ground and bond containers; keep container tightly closed; avoid spilling, splashing, or aerosol formation; wear protective clothing and eye protection
Safe Storage Conditions: Store in a cool, well-ventilated, fire-proof area away from incompatible materials (oxidizers, acids, bases); keep away from ignition sources; use approved containers
Incompatible Materials: Strong oxidizing agents, strong acids and bases, reactive metal powders
Bulk Storage Guidance: Drums and bulk containers should remain tightly sealed; protect from physical damage; use secondary containment
Transfer Precautions: Use spark-proof tools; control static discharge by bonding and grounding equipment
Exposure Limits: Workplace exposure limits typically set at 50 ppm (TWA, ACGIH for total vapor and aerosols), though exact limits depend on jurisdiction
Engineering Controls: Local exhaust ventilation strongly recommended to minimize vapor buildup; process enclosures where feasible
Personal Protection: Chemical splash goggles; impervious gloves (nitrile, neoprene, or butyl rubber best); long-sleeved clothing
Respiratory Protection: NIOSH-approved organic vapor respirator if exposure exceeds legal limits or ventilation inadequate
Hygiene Measures: Wash hands before breaks and after handling; do not eat, drink, or smoke during use; remove contaminated clothing before entering eating areas
Environmental Controls: Avoid release to the environment; use containment to minimize unauthorized discharges
Appearance: Colorless, transparent liquid
Odor: Mild ether-like odor
Odor Threshold: Detectable at low concentrations (around 10 ppm)
pH: Not applicable
Melting Point/Freezing Point: -64°C
Boiling Point/Range: 145–149°C
Flash Point: 42–45°C (closed cup)
Evaporation Rate: Slower than butyl acetate
Flammability (solid/gas): Not applicable
Upper/Lower Flammability Limits: 1.5% LEL, 7% UEL (by volume in air)
Vapor Pressure: 3.7 mmHg at 20°C
Vapor Density: 4.6 (air=1)
Relative Density: 0.96–0.97 g/cm³
Solubility: Miscible in most organic solvents; very slightly soluble in water
Partition Coefficient (log Kow): 0.43 (estimated)
Auto-ignition Temperature: 315°C
Decomposition Temperature: No data available
Viscosity: 1.2 mPa·s at 25°C
Chemical Stability: Stable under recommended conditions; not prone to rapid decomposition
Hazardous Reactions: May react with strong oxidizing agents or strong acids, forming flammable or toxic gases
Conditions to Avoid: Heat, sparks, open flames, static electricity, contact with incompatible substances
Hazardous Decomposition Products: Produces formaldehyde, carbon monoxide, and carbon dioxide if burned or decomposed in fire
Polymerization: Does not undergo hazardous polymerization
Likely Routes of Exposure: Inhalation, skin, eyes, ingestion
Acute Toxicity (Oral): LD50 (rat): >5000 mg/kg
Acute Toxicity (Dermal): LD50 (rabbit): >2000 mg/kg
Inhalation Toxicity: LC50 (rat, 4h): >4345 ppm
Skin/Eye Irritation: Causes moderate to severe eye irritation; may cause mild dermal irritation
Respiratory Sensitization: Not classified as sensitizer
Chronic Effects: Repeated exposure may lead to headache, dizziness, narcosis; no evidence of carcinogenicity in humans
Mutagenicity and Carcinogenicity: Not classified as mutagenic or carcinogenic based on available data
Reproductive Toxicity: Studies show no known reproductive effects in standard workplace settings
Aquatic Toxicity: Not classified as highly toxic to aquatic organisms; LC50 (fish, 96h): >100 mg/L
Persistence and Degradability: Readily biodegradable under aerobic conditions; breaks down rapidly in soil and water
Bioaccumulative Potential: Low partition coefficient suggests potential for bioaccumulation is low
Mobility in Soil: High mobility expected due to water solubility
Other Adverse Effects: No evidence of ozone depletion or persistent toxin formation
Waste Treatment Methods: Collect and dispose of using licensed waste contractor; incineration or approved chemical waste landfill preferred
Disposal of Containers: Triple-rinse empty containers, puncture, and send for recycling or disposal; do not pierce or burn
Precautions: Prevent entry to sewers or environment; follow local, national, and regional waste regulations
Sewage Disposal Recommendations: Do not dispose via drains; consult local authorities for guidance
UN Number: UN 3272
Proper Shipping Name: Esters, n.o.s. (contains Propylene Glycol 1-Monomethyl Ether 2-Acetate)
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Avoid exposure to heat; use grounding during transfer; package integrity checks recommended
Transport Label Required: Flammable liquid symbol
Other Regulatory Transport Details: IMDG, IATA, ADR, and domestic transport requirements apply; check with carrier and local rules
OSHA Regulation: Listed hazardous chemical; safety training and hazard communication standard applies
TSCA Status: Listed in the U.S. Toxic Substances Control Act Inventory
EU Regulation: Registered under REACH; classification and labeling rules apply; Safety Data Sheet must be readily accessible
SARA Title III: Not listed as an extremely hazardous substance; some states may have additional regulations
WHMIS (Canada): Controlled product; workplace labeling and SDS required
Other Local Requirements: State, provincial, and municipal laws may call for additional risk management steps; employers keep records of use and training
Labeling: Product requires clear labeling with hazard statements and pictograms under GHS or local regulations
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