Product Name: Propylene Glycol 1-Methyl Ether 2-Acetate
Synonyms: 1-Methoxy-2-Propyl Acetate, PMA
Chemical Formula: C6H12O3
CAS Number: 108-65-6
Recommended Use: Industrial solvent, coatings, inks, and cleaners
Restrictions on Use: Not for food, drug, or cosmetic purposes
Supplier Identification: Name, address, and 24-hour emergency contact number listed on product label
Emergency Phone: Refer to local, regional, or company emergency number indicated on container label
GHS Classification: Flammable liquid (Category 3), Eye Irritation (Category 2A), Specific Target Organ Toxicity – Single Exposure (Category 3)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Causes serious eye irritation. May cause drowsiness or dizziness.
Pictograms: Flame, Exclamation Mark
Precautionary Statements: Keep away from sparks, heat, open flames. Wear protective gloves and eye protection. Work in well-ventilated area. Avoid breathing vapors or mist. Store locked away from children.
Physical Hazards: Vapors may travel to ignition source.
Health Hazards: Eye irritant, CNS effects with overexposure (headache, dizziness, nausea)
Environmental Hazards: Harmful to aquatic life with long lasting effects.
Chemical Name: Propylene Glycol 1-Methyl Ether 2-Acetate
Concentration: 99%–100%
CAS Number: 108-65-6
Other Components: Trace impurities (less than 1%) may include related ethers or acetates, generally below hazardous concentration thresholds. No known carcinogens or reproductive toxins present above limit values.
Inhalation: Move affected person to fresh air quickly. Provide oxygen if breathing is difficult. Seek immediate medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing. Wash affected skin thoroughly with soap and water. If irritation continues, get medical advice.
Eye Contact: Rinse eyes immediately with plenty of clean, running water for at least 15 minutes, lifting upper and lower eyelids. Remove contact lenses if present. Contact an eye specialist urgently.
Ingestion: Rinse mouth; do not induce vomiting. Never administer anything by mouth to an unconscious person. Get prompt medical help. Monitor for respiratory distress.
Suitable Extinguishing Media: Use water fog, foam, dry chemical, or carbon dioxide. Avoid using straight water streams due to spreading risk.
Hazards from Combustion: Produces carbon monoxide, carbon dioxide, and possibly irritating or toxic fumes.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus (SCBA) and chemical protective clothing. Approach fire from upwind.
Special Fire-Fighting Procedures: Cool exposed containers with water. Remove them from fire area if possible.
Explosion Risk: Vapor may accumulate in confined spaces, flashback can occur far from ignition source.
Personal Precautions: Evacuate area if spill is large. Isolate hazard area. Avoid breathing vapors. Wear full chemical protective clothing, including eye protection and gloves.
Environmental Precautions: Prevent product run-off into drains, sewers, or soil. Notify authorities if contamination occurs.
Clean-up Methods: Absorb spill with non-combustible inert material such as sand, earth, or vermiculite. Scoop into labeled containers for proper disposal. Clean spill area with water and detergent.
Precautions for Safe Handling of Residues: Dispose of all contaminated materials according to local, regional, and national regulations.
Safe Handling: Use only in well-ventilated environments. Avoid direct contact with product or vapors. Do not eat, drink, or smoke near chemical use area. Wear chemical-resistant gloves, goggles, and protective clothing.
Storage Requirements: Store in cool, dry, well-ventilated places away from direct sunlight, heat sources, open flames, and incompatible chemicals (notably strong oxidizers, acids, alkalis). Store containers upright, tightly sealed.
Incompatibilities: Keep away from acids, bases, oxidizing agents.
Other Recommendations: Use recommended containers only. Label storage areas clearly. Keep emergency eyewash and shower equipment nearby.
Exposure Limits: ACGIH TLV: 50 ppm (8-hour TWA) for PMA (where applicable); OSHA PEL: not established, consult local regulation.
Engineering Controls: Ensure adequate general and local exhaust ventilation. Provide eyewash stations and safety showers in chemical handling areas.
Personal Protective Equipment: Use chemical splash goggles, face shield, and impervious gloves (nitrile or butyl rubber). Wear long-sleeved clothing or chemical apron. Use approved air-purifying respirators if ventilation is inadequate.
Hygiene Measures: Wash hands and exposed skin thoroughly after handling and before breaks or eating. Remove contaminated clothing and wash before reuse.
Appearance: Clear, colorless liquid
Odor: Mild, characteristic ether scent
Odor Threshold: 0.1–10 ppm (estimated)
pH: Not applicable (neutral liquid)
Melting/Freezing Point: -67°C (-89°F)
Boiling Point: 146°C (295°F)
Flash Point: 45°C (113°F) (closed cup)
Evaporation Rate: Slower than n-butyl acetate
Flammability: Flammable liquid
Vapor Pressure: 3.7 mmHg at 20°C
Vapor Density: 4.6 (air = 1)
Relative Density: 0.96 g/cm³ at 20°C
Solubility: Miscible with water, ethanol, and many organic solvents
Partition Coefficient (n-octanol/water): 0.43 (log Pow)
Autoignition Temperature: 315°C (599°F)
Decomposition Temperature: No data available
Viscosity: 1.2 mPa·s at 20°C
Chemical Stability: Stable under normal temperatures and pressures if kept away from incompatible materials.
Reactivity: Reacts with strong oxidizers, acids, and bases, producing heat and possibly hazardous fumes.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, and possibly irritating vapors if burned.
Polymerization: Hazardous polymerization does not occur under recommended storage and handling conditions.
Conditions to Avoid: Avoid static discharge, sparks, open flames, excessive heat, and direct sunlight.
Acute Toxicity: Oral LD50 (rat): 8,500 mg/kg. Dermal LD50 (rabbit): >5,000 mg/kg. Inhalation LC50 (rat, vapor, 4 hrs): >4,000 ppm.
Skin/ Eye Irritation: Can cause eye irritation (redness, tearing, pain); slight irritant for skin on prolonged exposure.
Respiratory Sensitization: May cause headaches, dizziness, and nausea after inhalation of concentrated vapors.
Chronic Effects: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity at occupational exposure levels.
Other Information: Not classified as a carcinogen by IARC, NTP, or OSHA. Minimal systemic toxicity with proper industrial practices.
Ecotoxicity: Aquatic toxicity (LC50, 96h, fish): >100 mg/L. Daphnia EC50 (48h): >500 mg/L. Algae EC50 (72h): >1,000 mg/L. Not expected to bioaccumulate.
Degradability: Readily biodegradable in aquatic environments under aerobic conditions. Breakdown by sunlight and microorganisms is expected.
Mobility: High solubility and low log Kow indicate high mobility in water and soil.
Other Adverse Effects: Product should not be discharged into drains, waterways, or soil in undiluted or large quantities.
Product Disposal: Incinerate under controlled conditions or landfill at an approved site, following all local, state, and federal environmental regulations.
Container Disposal: Drums and bottles should be triple-rinsed before recycling or disposal. Remove or deface labels prior to disposal to prevent reuse.
Contaminated Waste: Absorb spilled product using inert material and dispose of as hazardous waste. Avoid allowing wash water to enter storm drains.
UN Number: UN 3272
Proper Shipping Name: Esters, N.O.S. (contains Propylene Glycol 1-Methyl Ether 2-Acetate)
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Label Required: Flammable Liquid
Special Precautions: Transport in closed, upright containers. Secure against movement. Avoid exposure to direct sunlight, heat sources, or fire during transport.
Other Information: Review local and international regulations for additional shipping requirements or restrictions.
US TSCA status: Listed
OSHA: Considered hazardous material under 29 CFR 1910.1200
SARA Title III: Not listed as Extremelt Hazardous; not listed under Sections 302, 304, or 313.
DSL (Canada): Listed
EINECS (EU): 203-603-9
WHMIS Classification (Canada): B2 (Flammable Liquid), D2B (Toxic Material causing other toxic effects)
Other National Regulations: Check specific regional guidelines. May be subject to additional restrictions in certain countries or municipalities.
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