Product Name: Poly(propylene glycol) 1000
Chemical Family: Polyether polyol
CAS Number: 25322-69-4
EC Number: 500-039-8
Recommended Uses: Used as an intermediate in polyurethane production, lubricants, hydraulic fluids, surfactant formulations, and other industrial applications
Supplier Information: Industrial chemical manufacturers and distributors; specific supplier addresses and emergency phone lines provided in full documentation for workplace labeling and communication purposes.
GHS Classification: Not classified as hazardous according to GHS criteria for this product
Label Elements: No hazard symbol, no signal word
Hazard Statements: May cause mild eye irritation; may lead to skin irritation with prolonged and frequent contact
Precautionary Statements: Avoid direct contact with eyes, skin, and clothing; maintain good industrial hygiene and workplace safety using best available controls
Other Hazards: Can create slippery surfaces; spillage increases risk for slips and falls near workstations.
Chemical Identity: Poly(propylene glycol)
Concentration: 95-100% by weight
CAS Number: 25322-69-4
Impurities/Stabilizing Additives: Residual monomers or antioxidant stabilizers present at less than 1% each; details may vary depending on batch and supplier.
Eye Contact: Rinse cautiously with plenty of water for several minutes; remove contact lenses if present and easy to do; continue rinsing until irritation stops or medical advice is available
Skin Contact: Wash with soap and water; remove contaminated clothing and launder before reuse; if skin irritation occurs, seek medical attention
Inhalation: Move person to fresh air; clear airways; monitor for breathing difficulty and get medical help if symptoms persist
Ingestion: Rinse mouth with water once or twice; avoid inducing vomiting; seek medical advice for large amounts or persistent discomfort
Most Important Symptoms/Effects: Mild eye and skin irritation; no delayed or long-term effects observed in typical workplace exposures.
Suitable Extinguishing Media: Water fog, carbon dioxide, alcohol-resistant foam, or dry chemical extinguishers
Unsuitable Extinguishing Media: Avoid high pressure water streams that may spread spilled product
Special Hazards Arising from Substance: May produce oxides of carbon, acrid smoke, and other organic vapors when burned
Advice for Firefighters: Use full protective gear and positive-pressure self-contained breathing apparatus; keep containers cool with water spray
Additional Information: Fire may cause heating and rupture of containers; runoff water can cause contamination in drainage.
Personal Precautions: Avoid breathing vapors or mists; ventilate area well; prevent trip hazards from spillage
Protective Equipment: Suitable gloves, safety goggles, and standard work clothing
Emergency Procedures: Evacuate non-essential personnel; restrict access until cleanup is complete
Containment Methods: Stop leak if safe; prevent further spillage or release to sewers and waterways
Cleanup Methods: Absorb with sand, earth, or inert absorbent; collect in suitable containers for disposal; clean area with detergent and copious water.
Safe Handling Advice: Use only with adequate ventilation; keep containers tightly closed; avoid contact with eyes and prolonged skin exposure; avoid ingestion and inhalation
Storage Conditions: Store in original containers in a cool, dry, well-ventilated area; keep away from heat and direct sunlight; prevent unnecessary contact with moisture
Incompatible Materials: Strong oxidizing agents, acids, and isocyanates
Specific End Uses: Refer to manufacturer’s technical bulletins for safe and appropriate end user applications and handling.
Control Parameters: Occupational exposure limits not established for this product; monitor workplace for nuisance mist levels during spray or atomized applications
Engineering Controls: Good general ventilation for routine operations; local exhaust for processes generating mist or aerosol
Eye Protection: Chemical splash goggles or face shield depending on risk assessment
Skin Protection: Chemical-resistant gloves (nitrile, neoprene, or butyl rubber); work clothing as needed
Respiratory Protection: Not typically required for handling at room temperature; use approved respiratory equipment if airborne concentrations exceed recommended limits in confined spaces
Hygiene Measures: Wash hands thoroughly after handling; avoid eating, drinking, or smoking in work areas.
Appearance: Clear to hazy, colorless to pale yellow liquid
Odor: Mild, characteristic polyether odor
Odor Threshold: No data available
pH: Not applicable (insoluble in water, forms emulsions)
Melting Point/Freezing Point: -35 to -20 °C
Boiling Point/Range: >200 °C at standard pressure
Flash Point: 200–220 °C (Closed cup)
Evaporation Rate: Negligible under ambient conditions
Flammability: Product is considered combustible but not highly flammable
Upper/Lower Flammability or Explosive Limits: No established limits for vapors
Vapor Pressure: < 1 mm Hg at 20 °C
Vapor Density: Not determined
Relative Density: 1.0–1.1 (Water = 1)
Solubility: Miscible with many organic solvents; low solubility in water
Partition Coefficient (n-octanol/water): Not determined
Autoignition Temperature: 370 °C
Decomposition Temperature: >250 °C
Viscosity: 800–1200 mPa·s at 25 °C
Chemical Stability: Stable under recommended conditions of use and storage
Possibility of Hazardous Reactions: No dangerous reactions with common materials under normal use; reacts with strong oxidizers and acids
Conditions to Avoid: Excessive heat, open flames, prolonged exposure to air or moisture
Incompatible Materials: Strong oxidizing agents, strong acids, isocyanates
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, low molecular weight hydrocarbons and traces of formaldehyde.
Acute Toxicity: Oral LD50 (rat): >5000 mg/kg; Dermal LD50 (rabbit): >2000 mg/kg; practically non-toxic by standard routes of exposure
Skin Corrosion/Irritation: Mild, reversible irritation possible with repeated or prolonged contact
Serious Eye Damage/Irritation: Mild and transient irritation possible
Respiratory or Skin Sensitization: No evidence of sensitization based on animal studies and occupational exposure history
Germ Cell Mutagenicity: No mutagenic effects observed in in vitro or in vivo test systems
Carcinogenicity: Not classified as a human carcinogen by the International Agency for Research on Cancer (IARC), U.S. EPA, or NTP
Reproductive Toxicity: No developmental or reproductive effects identified in industry use or laboratory testing
Specific Target Organ Toxicity: Not classified for target organ toxicity from repeat exposure
Information on Likely Routes of Exposure: Inhalation and skin contact most relevant routes in industrial settings.
Ecotoxicity: Low acute toxicity to aquatic organisms; fish (LC50, 96 h): >100 mg/L; daphnia (EC50, 48 h): >100 mg/L; algae (EC50, 72 h): >100 mg/L
Persistence and Degradability: Readily biodegradable according to OECD criteria; breaks down in biological wastewater treatment systems
Bioaccumulative Potential: Low potential for bioaccumulation based on low log Kow and water solubility
Mobility in Soil: Moderate mobility; may leach if spilled in large amounts, but tends to be retained in organic-rich soils
Other Adverse Effects: Product is not subject to marine pollutant labeling; environmental impact minimized by proper containment and disposal practices.
Waste Treatment Methods: Recycle and reuse whenever possible; incinerate in a facility equipped to handle organic chemical wastes; follow local, regional, and national regulations for chemical disposal
Contaminated Packaging: Rinse containers thoroughly before recycling or disposal; puncture or crush to prevent unauthorized reuse
Additional Recommendations: Do not dump in drains, watercourses, or landfill; contractors handling waste streams should review all applicable regulations before transport or disposal.
UN Number: Not regulated for transport under ADR, IMDG, or IATA codes
UN Proper Shipping Name: Poly(propylene glycol); non-hazardous for ground, air, or marine shipments
Transport Hazard Class: Not restricted
Packing Group: Not assigned
Environmental Hazards: None identified for transport purposes; avoid release into environment during routine handling
Special Precautions for User: Ensure containers are tightly closed and securely stowed to prevent leakage or tipping in transit; maintain documentation as required by regional standards.
Safety, Health, and Environmental Regulations: Listed on international chemical inventories including TSCA (USA), EINECS/ELINCS (EU), DSL (Canada), ENCS (Japan), AICS (Australia), and others
Specific Legislative Requirements: Product does not require classification or labeling as hazardous according to EU CLP Regulation (EC No. 1272/2008), OSHA Hazard Communication Standard (29 CFR 1910.1200), or other major national worker protection rules
SARA Title III, Section 313: Not subject to reporting
California Proposition 65: Not listed for any cancer or reproductive hazard warnings
Chemical Safety Assessment: Assessment completed; safe use guidelines provided in this MSDS support effective risk management at industrial and downstream facilities.
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