Product Name: Plus-Minus-Phenylpropanolamine Hydrochloride
Synonyms: PPA Hydrochloride, DL-Norephedrine Hydrochloride
Chemical Formula: C9H13NO·HCl
CAS Number: 14838-15-4
Intended Use: Pharmaceutical intermediate, decongestant
Manufacturer: Details available upon request from supplier
Emergency Contact: Refer to supplier’s emergency information or local poison control
Recommended Restrictions: Industrial and laboratory use only; not for food or cosmetic use
GHS Classification: Acute toxicity (oral, category 4); Skin irritation (category 2); Eye irritation (category 2A)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves and eye protection, rinse mouth if ingested
Symptoms of Exposure: Headache, nausea, rapid heart rate, hypertension, skin redness, eye discomfort
NFPA Ratings: Health: 2 Flammability: 1 Instability: 0
Potential Routes of Exposure: Ingestion, inhalation, skin/eye contact
Substance: Plus-Minus-Phenylpropanolamine Hydrochloride
Purity: ≥98% by weight
Impurities: Trace levels of related phenylpropanolamine isomers, moisture content below 0.5%
Excipient/Additive Content: None, pure active substance
Chemical Family: Sympathomimetic amine salt
Molecular Weight: 187.67 g/mol
Inhalation: Move person to fresh air, monitor for respiratory distress, seek medical help if symptoms develop
Skin Contact: Remove contaminated clothing, wash affected skin with soap and water, call physician if irritation persists
Eye Contact: Immediately flush with plenty of clean water for at least 15 minutes, take care to remove contact lenses, seek medical attention if discomfort continues
Ingestion: Rinse mouth, drink water if conscious, contact poison center or physician, do not induce vomiting without medical advice
Acute Symptoms: Fast heartbeat, agitation, dry mouth, high blood pressure, possible seizures with high doses
Workplace Response: Have safety shower and eyewash station nearby; keep emergency numbers accessible
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, alcohol-resistant foam
Unsuitable Extinguishing Media: Direct water jet (may spread powder)
Fire Hazards: Emits toxic fumes under combustion including nitrogen oxides, carbon monoxide, hydrochloric acid vapors
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective gear
Explosion Risk: Dust may form explosive mixture in air in rare, confined circumstances
Thermal Decomposition: Byproducts include HCl gas and amines
Special Procedures: Contain runoff, cool exposed containers, keep away from ignition sources
Personal Precautions: Avoid contact with skin and eyes, use appropriate PPE such as gloves, goggles, and a dust mask
Environmental Precautions: Prevent powder from entering drains, surface water, or soil
Clean-Up Methods: Sweep up without generating dust, use a HEPA filter vacuum or damp cloth for residual material, place collected material into closed containers for disposal
Decontamination: Wash affected area with water and detergent, ventilate area thoroughly
Emergency Procedures: Evacuate unnecessary personnel, stop leak if safe to do so, isolate contaminated area
Reporting: Notify local authorities if large spills pose environmental hazard
Handling: Avoid inhalation, ingesting, or contact with skin and eyes; use in a well-ventilated area with local exhaust; handle with care to prevent spills
Technical Controls: Use fume hood or equivalent ventilation; have safety measures in place
Hygiene Practices: Do not eat, drink, or smoke during use, wash hands after handling, keep work clothing separate
Storage Conditions: Store in a cool, dry, well-ventilated area, protect from sunlight and moisture, keep container tightly closed
Incompatible Materials: Strong oxidizers, strong acids, relies on absence of excess moisture
Storage Requirements: Use original packaging or compatible secondary containment, label containers clearly
Occupational Exposure Limits: No specific exposure limit established; handle as hazardous chemical
Engineering Controls: Fume hood, local exhaust ventilation, negative air pressure in storage areas
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), safety goggles or face shield, lab coat or apron, respiratory protection in case of dust formation (N95 mask or higher)
Industrial Hygiene: Avoid splashing, use closed systems where possible, routinely clean work surfaces, change protective clothing if contaminated
Monitor Exposure: Regular health surveillance for frequent handlers
Additional Controls: Eyewash stations, safety showers, alarm for detection of chemical release
Appearance: White or off-white crystalline powder
Odor: Odorless or faint amine-like scent
pH (1% solution): Approximately 4-5
Melting Point: 190–193°C
Boiling Point: Decomposes before boiling
Solubility: Freely soluble in water, slightly soluble in alcohol, insoluble in ether
Vapor Pressure: Negligible at room temperature
Density: 1.05–1.10 g/cm³
Partition Coefficient (log Kow): Not applicable/low; does not bioaccumulate
Flash Point: Not applicable, not a liquid
Other Data: Stable under recommended storage, sensitive to prolonged exposure to light and moisture
Stability: Chemically stable under normal storage and handling
Conditions to Avoid: Excess heat, exposure to direct sunlight, contact with moisture or water during storage
Incompatible Materials: Strong oxidizers, strong acids, bases (may cause degradation)
Hazardous Decomposition Products: Hydrochloric acid, nitrogen oxides, carbon monoxide, and ammonia compounds during combustion or high-temperature decomposition
Polymerization: Will not occur
Other Reactivity Notes: Stable in neutral, dry environments; reacts with bases to liberate free amine
Acute Toxicity (Oral, LD50): Rat 440 mg/kg; classified as moderately toxic
Acute Toxicity (Dermal): Data insufficient; mild to moderate irritant
Skin and Eye Irritation: Causes transient redness, discomfort, or swelling
Respiratory Effects: Dust can irritate nasal passages and upper airways
Chronic Effects: Extended or repeated exposure may affect cardiovascular and central nervous systems
Sensitization: No known sensitization risk documented
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: Some evidence of developmental toxicity in animals at high doses
Other Health Effects: High doses or misuse associated with hypertension, stroke risk
Symptoms of Poisoning: Palpitations, tremors, convulsions, CNS stimulation
Ecotoxicity: Limited data; low to moderate aquatic toxicity expected based on chemical properties
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulation: Low potential, low log Kow value
Mobility in Soil: High solubility suggests moderate mobility in environment if released
Environmental Fate: Unlikely to accumulate, subject to microbial breakdown
Aquatic Toxicity: No data specific to fish or invertebrates, treat as hazardous to aquatic life as precaution
Other Effects: Avoid uncontrolled release to water bodies and sewage systems
Waste Treatment Methods: Dispose of as hazardous chemical waste; preferred route is incineration under controlled conditions with appropriate scrubbers
Contaminated Packaging: Rinse with water, dispose of in accordance with local, regional, and national requirements
Environmental Precautions: Prevent contamination of surface water, soil, and sewers
Precaution for Disposal Workers: Use personal protection, avoid dust generation
Regulatory Waste Code: Consult local codes; typically classified as pharmaceutical or chemical waste
UN Number: Not assigned specifically, ship as regulated pharmaceutical intermediate
Transport Hazard Class: Not classified as hazardous for ground, air, or sea transport under most jurisdictions, double-check with local authorities for bulk shipments
Packing Group: Not classified; use sturdy, sealed chemical containers
Special Precautions: Avoid contact with incompatible materials during shipment, protect from heat and moisture
Labeling Requirements: Follow regional labeling standards for chemical products
Emergency Response: Refer to transport emergency card and local authority procedures in case of spillage or fire during transport
Inventory Status: Listed in many national chemical inventories; check local requirements
Controlled Status: Prescription restricted or controlled substance in many countries due to abuse potential
OSHA Status: Not specifically regulated, general hazard communication standards apply
REACH/CLP (EU): Not registered for bulk trading, comply with REACH notification for research or specialty use
WHMIS Classification (Canada): Not classified; follow workplace controls for bioactive chemical substances
Other Regulations: Subject to regulations governing pharmaceutical and controlled precursor chemicals; disposal and usage may require permits and notification to authorities
Labels Required: Hazard, precautionary, and first-aid information must appear on all containers as required by regional law
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