Product Name: Pimavanserin Tartrate
Chemical Formula: C25H34FN3O2 · C4H6O6
Synonyms: ACP-103, Pimavanserin tartrate salt
CAS Number: 706779-19-3
Recommended Use: Active pharmaceutical ingredient for research purposes
Manufacturer: Acadia Pharmaceuticals Inc.
Emergency Phone: Company emergency line for chemical incidents
Address: Provided by manufacturer label or data sheet
Hazard Classification: Not classified as hazardous according to GHS, but limited human data exists
Acute Toxicity: Low evidence; dust can irritate eyes, skin, or respiratory tract
Signal Word: Caution recommended, as risks from chronic exposure remain unclear
Hazard Pictograms: None mandated, but avoid contact and inhalation
Health Effects: Inhalation or ingestion could cause effects on central nervous system including dizziness or sleepiness; no skin sensitization documented
Precautionary Statements: Use personal protective equipment, avoid dust formation, and maintain good industrial hygiene
Chemical Name: Pimavanserin Tartrate
Concentration: 100% (pure sample for laboratory use; for mixtures, see product label)
Impurities: Routine synthesis produces trace organics; verify with certificate of analysis
EC Number: Not assigned
Relevant Identifiers: Drug substance for research purposes only
Inhalation: Move to fresh air; breathe comfortably; seek medical attention if symptoms appear
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses; seek medical attention if irritation persists
Ingestion: Rinse mouth with water; seek medical advice, especially if large amounts are swallowed
Most Important Symptoms: Possible irritation to respiratory tract, eyes, and skin; high exposure could affect central nervous system
Immediate Medical Attention: Treat symptomatically, prioritize airway management in severe cases
Suitable Extinguishing Media: Use water spray, dry chemical, CO2, or foam
Unsuitable Media: Do not use direct water stream; dust may become airborne
Specific Hazards: Combustion can release toxic fumes including nitrogen oxides, carbon oxides, and hydrogen fluoride
Special Protective Equipment: Wear self-contained breathing apparatus and protective clothing
Advice for Firefighters: Use water spray to cool containers; avoid inhaling vapors and dust
Personal Precautions: Wear gloves, goggles, lab coat, and dust mask; prevent further spillage
Environment Precautions: Avoid release to sewers, soil, or drains
Cleaning Methods: Sweep up carefully and place in suitable container for disposal; wipe surfaces with damp cloth
Ventilation: Ensure adequate airflow in the affected area
Disposal: Dispose of collected materials as per section 13
Handling: Handle in well-ventilated areas using protective equipment; avoid dust generation; wash hands after handling
Hygiene: Do not eat, drink, or smoke during use; remove contaminated clothing and wash before reuse
Storage: Store in tightly closed container, protected from light, moisture, and incompatible chemicals
Temperature: Keep at recommended ambient or controlled room temperature; consult label for exact range
Incompatible Materials: Avoid strong acids, bases, and oxidizers
Engineering Controls: Use chemical fume hood and local exhaust ventilation
Eye Protection: Safety goggles or face shield
Hand Protection: Nitrile gloves recommended
Skin Protection: Laboratory coat or apron; avoid skin exposure
Respiratory Protection: Particulate respirator or dust mask if exposure limits are exceeded
Exposure Limits: No established workplace exposure limits; minimize exposure as a precaution
Environmental Controls: Prevent product entry into drains, sewers, and natural waterways
Appearance: Off-white to white powder
Odor: No characteristic odor
Odor Threshold: Not established
pH: Not available
Melting Point/Freezing Point: 180-190 °C (approximate, check specification)
Boiling Point: Not determined
Flash Point: Not data available
Evaporation Rate: Not determined
Flammability: Not flammable per standard definitions
Upper/Lower Flammability Limits: Not available
Vapor Pressure: Not applicable (solid)
Vapor Density: Not applicable
Relative Density: Not available
Solubility: Slightly soluble in water; soluble in DMSO, ethanol
Partition coefficient (log Pow): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 190 °C (approximate)
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: No dangerous reactions expected under normal handling
Conditions to Avoid: Excessive heat, moisture, light
Incompatible Materials: Strong acids, bases, oxidizing agents
Hazardous Decomposition Products: Thermal decomposition produces toxic gases: carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen fluoride
Acute Toxicity: Data limited; low oral toxicity in animal studies; carcinogenicity, mutagenicity, or reproductive toxicity not definitively reported
Skin Contact: Possible mild irritation
Eye Contact: Moderate irritation risk
Inhalation: Respiratory discomfort possible if dust is inhaled
Chronic Effects: Unknown in humans; pharmacological class suggests central nervous system effects if repeatedly or massively exposed
Sensitization: Not reported
LD50: Data from animal testing rare; values above 500 mg/kg (oral, rat) but consult updated sources
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Ecotoxicity: No acute or chronic aquatic toxicity data; prevent uncontrolled environmental release
Persistence and Degradability: Not rapidly biodegradable
Bioaccumulation Potential: Low, due to solubility and molecular size
Mobility in Soil: Not likely to leach extensively, but insufficient field data
Other Adverse Effects: Protect aquatic life from accidental contamination
Disposal Methods: Collect and send to licensed chemical incinerator or approved hazardous waste facility
Container Disposal: Triple rinse containers before disposal; remove labels; follow local regulations
Precautions: Do not dispose in household waste or general trash; do not allow to reach aquatic environments
Waste Code: Follow country-specific waste designation for pharmaceuticals
UN Number: Not classified as a hazardous material for transport
UN Proper Shipping Name: Not regulated for transport
Transport Hazard Class: None
Packing Group: None
Environmental Hazards: Prevent accidental release into natural settings
Special Precautions: Avoid packages rupturing; ship in accordance with good laboratory practices
Inventories: Not generally listed under major chemical inventories as a common substance
OSHA Status: Not classified as hazardous
TSCA/DSL: Not listed for commercial distribution
SARA Title III: Not subject to reporting
California Proposition 65: No ingredients known to cause cancer or reproductive toxicity as of latest updates
REACH Status: Not registered for non-research use
Other Regulatory Notes: Use restricted to qualified personnel in authorized setups
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