Product Name: Phenylpropanolamine Hydrochloride
Chemical Formula: C9H14ClNO
Synonyms: PPA HCl, Alpha-(1-Aminoethyl)benzyl alcohol hydrochloride
CAS Number: 51-06-9
Intended Use: Decongestant and appetite suppressant in pharmaceutical applications
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Contact Number for Emergency: [Insert Emergency Number As Applicable]
Classification: Harmful if swallowed; irritant to eyes, skin, and respiratory tract
Signal Word: Warning
Hazard Statements: May cause central nervous system stimulation, increased blood pressure, and cardiovascular effects; dust may cause eye or respiratory irritation; ingestion in excess can lead to severe hypertension, seizures, or cardiovascular collapse
Precautionary Statements: Avoid contact with skin, eyes, and clothing; prevent inhalation of dust; use appropriate personal protective equipment; maintain good industrial hygiene practices
Symptoms of Overexposure: Headache, dizziness, palpitations, anxiety, nausea, vomiting, increased heart rate
Chemical Name: Phenylpropanolamine Hydrochloride
Concentration: >99% (pure substance)
CAS Number: 51-06-9
Impurities: Trace amounts of related substances and residual solvents (if pharmaceutical grade)
Inhalation: Move individual to fresh air, monitor breathing, seek medical attention if symptoms persist
Skin Contact: Wash affected area thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes holding eyelids open, seek medical advice if irritation continues
Ingestion: Do not induce vomiting, rinse mouth, seek immediate medical care, provide information about substance ingested
Most Important Symptoms: Headache, confusion, rapid heart rate, hypertension
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray
Hazards from Combustion: May emit toxic fumes, including nitrogen oxides, hydrogen chloride, and carbon monoxide
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear
Precautions: Cool containers with water if exposed to fire, avoid inhaling combustion products
Specific Hazards: Fine dust can form explosive mixtures with air
Personal Precautions: Use proper personal protective equipment, including gloves, goggles, and dust mask; avoid generation of dust
Environmental Precautions: Prevent entry into drains, surface water, or soil
Spill Cleanup: Sweep or vacuum up spilled material with non-sparking tools, place in labeled containers for disposal, wash spill site with water after material pick-up
Ventilate Area: Ensure adequate ventilation during cleanup
Handling: Avoid contact with skin and eyes, avoid inhalation of dust, keep containers tightly closed, use in a well-ventilated area, practice good housekeeping and hygiene
Storage: Store at room temperature, keep away from incompatible materials such as strong oxidizers, acids, and bases, store in original container in a cool, dry, well-ventilated area, protect from moisture and direct sunlight
Occupational Exposure Limits: No established OSHA or ACGIH limits
Appropriate Engineering Controls: Use local exhaust ventilation or other engineering controls to keep airborne levels below recommended exposure limits
Personal Protective Equipment: Protective gloves (nitrile or latex), safety goggles, laboratory coats, dust mask or respirator suitable for particulate matter, closed footwear
Hygiene Measures: Wash hands before eating, drinking, or smoking; avoid contamination of clothing; remove contaminated clothing and wash before reuse
Physical State: White crystalline powder
Color: White
Odor: Odorless or faint amine scent
Melting Point: 188–194°C
Boiling Point: Decomposes before boiling
Solubility: Highly soluble in water, slightly soluble in ethanol
pH (1% solution): 4.0–5.0
Density: Approximately 1.1 g/cm³
Flash Point: Not applicable
Partition Coefficient (Octanol/Water): Not available
Chemical Stability: Stable under normal temperatures and pressures when kept dry and tightly sealed
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: May produce nitrogen oxides, hydrogen chloride, carbon oxides on decomposition
Conditions to Avoid: Heat, moisture, contact with incompatible substances, generation of dust
Polymerization: Will not occur under recommended storage and handling conditions
Routes of Entry: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: Oral LD50 (rat): ~126 mg/kg
Potential Health Effects: Central nervous system effects, hypertension, nausea, vomiting, restlessness, agitation; severe cases can include arrhythmias, seizures, or cardiovascular collapse
Chronic Exposure: Repeated or prolonged exposure may affect blood pressure, provoke CNS responses, and adversely impact cardiovascular function
Carcinogenicity: Not listed by IARC, NTP, OSHA as carcinogenic
Sensitization: Not known to cause sensitization in tested individuals
Aquatic Toxicity: Data limited; possible moderate toxicity to aquatic organisms
Persistence and Degradability: Expected to degrade slowly in the environment
Bioaccumulation Potential: Potential for bioaccumulation not established
Mobility in Soil: Soluble, may migrate in water; possible groundwater contaminant
Other Adverse Effects: No specific data on ozone depletion, greenhouse gas emission, or PBT (Persistent, Bioaccumulative, Toxic) assessment
Disposal Methods: Dispose of in accordance with local, state, and federal regulations; incineration preferred where permitted; do not discharge into drains or environment
Contaminated Packaging: Containers should be triple-rinsed and disposed as hazardous chemical waste
Waste Codes: As applicable under local regulatory classification
Special Precautions: Handle waste using proper protective equipment and prevent environmental contamination
UN Number: Not regulated for transport as a dangerous good under UN Recommendations
Proper Shipping Name: Phenylpropanolamine Hydrochloride
Hazard Class: Not classified as hazardous for road, rail, sea, or air transport
Packing Group: Not applicable
Special Precautions: Avoid movement that could rupture packaging; ensure containers are tightly sealed and properly labeled during transport
Transport in Bulk: Transport in approved containers in compliance with local legislations
US Federal Regulations: Listed in TSCA inventory; regulated as a controlled substance precursor in some jurisdictions; check FDA regulations for pharmaceutical applications
EU Regulations: Listed in EINECS/ELINCS, subject to REACH restrictions; considered for medicinal product directives
Other Country Regulations: Controlled drug precursor in Canada and Australia; subject to monitoring and reporting requirements
Labeling Requirements: Product must be labeled as hazardous in accordance with local and international standards; proper hazard warnings, first-aid instructions, and emergency contact information
Workplace Safety: Subject to OSHA Hazard Communication Standard and WHMIS in Canada
Restrictions on Use: Prescription-only drug in the US and other countries due to potential for misuse, toxicity, and adverse effects
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