Material Safety Data Sheet: Oxedrine Tartrate

Identification

Product Name: Oxedrine Tartrate
Synonyms: Synephrine tartrate, p-synephrine tartrate
Chemical Formula: C18H23NO6
Molecular Weight: 349.38 g/mol
CAS Number: 62-54-4
Intended Use: Research, pharmaceutical applications
Manufacturer/Supplier: Information available on packaging or supplier dossier
Contact Information: Emergency number and address provided by supplier

Hazard Identification

Classification: Acute toxicity (oral), irritant
Signal Word: Warning
Hazard Statements: Causes mild to moderate eye and skin irritation, harmful if swallowed
Health Hazards: Headache, dizziness, rapid pulse, nausea, possible cardiovascular stress
Environmental Hazards: May be harmful to aquatic life with long lasting effects
Label Pictogram: Exclamation mark
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gear

Composition / Information on Ingredients

Chemical Name: Oxedrine Tartrate
Purity: Typically ≥ 98%
Impurities: Trace contaminants may be present depending on the supplier
Ingredient: Oxedrine base with tartaric acid
Hazardous Components: Oxedrine portion provides pharmacological activity, tartaric acid generally regarded as safe
Occupational Exposure Limits: Not established, handle as pharmaceutical active compound

First Aid Measures

Inhalation: Move person to fresh air, loosen clothing, seek medical advice for persistent symptoms
Skin Contact: Remove any contaminated clothing, wash skin with plenty of water and soap, seek attention for lesions or irritation
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy, consult medical care if discomfort persists
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice especially if large amounts swallowed or symptoms present
General Advice: Show the label or safety data sheet to healthcare personnel

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, foam or CO2 extinguishers
Unsuitable Media: Avoid water stream for large fires
Specific Hazards: Decomposition may release irritating fumes such as nitrogen oxides, carbon monoxide, carbon dioxide
Special Protective Equipment: Wear self-contained breathing apparatus and protective suit
Advice for Firefighters: Evacuate area, control runoff, keep containers cool using water spray

Accidental Release Measures

Personal Precautions: Wear gloves, safety glasses, dust mask or respirator
Environmental Precautions: Prevent spillage from entering sewers or water bodies
Containment: Cover spill with absorbent material, sweep up without generating dust, place in a tightly closed container
Clean-up Methods: Dispose of collected material according to local regulations, ventilate area thoroughly

Handling and Storage

Handling: Use in well-ventilated area, limit dust, avoid contact with eyes or skin, wash thoroughly after use, do not eat or drink nearby
Storage Conditions: Keep in tightly sealed container away from heat and light, store at room temperature or as specified by manufacturer
Incompatible Materials: Strong oxidizing agents, strong acids
Storage Class: Pharmaceutical laboratory chemical
Other Instructions: Label container clearly, keep out of reach of unauthorized persons, maintain updated inventory records

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not officially assigned, use pharma active guidelines
Engineering Controls: Work in fume hood, use closed handling processes where possible, employ general ventilation
Personal Protection: Nitrile gloves, safety goggles, laboratory coat or coveralls, NIOSH/MSHA approved dust mask
Hygiene Measures: Wash hands before breaks and at end of work, remove contaminated clothing
Special Instructions: Keep exposure as low as reasonably achievable, maintain regular health monitoring for laboratory staff

Physical and Chemical Properties

Physical State: Solid, crystalline powder
Color: White or nearly white
Odor: Odorless to faint odor
pH: Not applicable as a solid
Melting Point: Approximately 187-189 °C
Boiling Point: Decomposes before boiling
Flash Point: Not flammable
Solubility: Soluble in water, partially soluble in alcohol
Vapor Pressure: Not applicable at room temperature
Density: 1.38–1.45 g/cm³
Partition Coefficient (log Kow): Not determined
Stability: Stable in closed containers under specified storage conditions

Stability and Reactivity

Chemical Stability: Stable if stored correctly in original packaging out of sunlight and away from moisture
Possibility of Hazardous Reactions: No dangerous reactions known under normal conditions
Conditions to Avoid: Elevated temperatures, excessive moisture, direct sunlight
Incompatible Materials: Strong acids, strong bases, oxidizers
Hazardous Decomposition Products: Fumes of nitrogen oxides and carbon oxides on combustion or decomposition

Toxicological Information

Acute Toxicity: Data for oral rat LD50 approximately 150–170 mg/kg
Irritation: May cause mild to moderate eye and skin irritation on direct contact
Chronic Exposure: Prolonged exposure may result in disturbance of cardiovascular system
Routes of Exposure: Inhalation, skin, ingestion
Symptoms: Palpitations, tremors, nausea, elevated blood pressure in sensitive subjects
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Mutagenicity: Mutagenicity data not sufficient
Reproductive Toxicity: No definitive data regarding reproductive impacts, precaution recommended for pregnant women

Ecological Information

Ecotoxicity: Limited data, structurally related compounds show low aquatic toxicity at low concentrations
Persistence and Degradability: Expected to be biodegradable, but rate and pathway depend on conditions
Bioaccumulative Potential: Not expected to bioaccumulate significantly
Mobility in Soil: Likely to be mobile, soluble in water
Other Adverse Effects: May cause temporary disruption to aquatic microflora at high concentrations
Special Precautions for Environment: Prevent release into waterways or environments where bioactive compounds can accumulate

Disposal Considerations

Waste Treatment Methods: Incinerate at an authorized chemical waste facility or dispose through licensed hazardous waste contractor
Contaminated Packaging: Decontaminate before reusing or offer to hazardous waste disposal
Local Disposal Regulations: Adhere to regional, national, and local environmental control requirements
Environmental Precautions: Avoid contamination of soil, water and sewage systems, track disposal records

Transport Information

UN Number: Not classified as dangerous for transport
Shipping Name: Oxedrine Tartrate
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Environmental Hazards: Not classified as a marine pollutant
Transport Precautions: Secure packaging to prevent release, transport according to regional chemical guidelines
Special Instructions: Carry safety data sheet with shipment, label clearly for identification during transit

Regulatory Information

Chemical Inventory Status: Listed on most international and national chemical inventories
Labelling Regulations: Follow OSHA Hazard Communication Standard, GHS, EU CLP guidelines
Restrictions: May be restricted or controlled under drug precursor, pharmaceutical or supplement regulations
Other Regulations: Subject to food, pharmaceutical, and workplace safety bodies for human exposure restrictions
Workplace Classification: Not classified as carcinogen, reproductive or mutagenic hazard under global harmonized systems but handle as a bioactive compound with care
Advice: Maintain access to current safety data sheet, provide suitable training for staff