Product Name: Norepinephrine Tartrate
Chemical Name: 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol tartrate
Synonyms: Noradrenaline bitartrate, Levonorepinephrine tartrate
CAS Number: 119-06-0
Intended Use: Pharmaceutical applications, research and development
Manufacturer: [Insert Responsible Manufacturer Name]
Emergency Contact: [Insert Emergency Contact Number and Address]
Classification: Acute toxicity category 3 (oral), Eye irritation category 2A, Skin sensitization, Specific target organ toxicity-single exposure
Hazard Statements: Toxic if swallowed. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.
Pictograms: Skull and crossbones, exclamation mark
Signal Word: Danger
Routes of Entry: Inhalation, ingestion, skin absorption, eye contact
Effects of Exposure: Tachycardia, hypertension, anxiety, shortness of breath, irritation to eyes and skin, potential cardiovascular events
Chemical Name: Norepinephrine tartrate
Concentration: >98% by weight
Molecular Formula: C8H11NO3·C4H6O6
Molecular Weight: 337.29
Impurities: Trace synthesis by-products, less than 1% combined
Other Constituents: None that impact classification or handling precautions
Inhalation: Move exposed individual to fresh air immediately. Give artificial respiration if breathing stops, provide oxygen if difficulty breathing. Seek medical attention.
Skin Contact: Rinse affected area with large volumes of water for at least 15 minutes. Remove contaminated clothing, launder before reuse. Consult a physician.
Eye Contact: Rinse eyes cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical advice.
Ingestion: Rinse mouth with water. Do not induce vomiting. Keep person calm and seek immediate medical care.
Potential Acute Effects: Nausea, vomiting, headache, severe cardiovascular symptoms, possible anaphylaxis.
Note for Physicians: Symptomatic and supportive treatment. Close monitoring of cardiovascular status.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, water spray
Unsuitable Media: Direct water jet (may spread material)
Hazards from Combustion: Toxic gases such as carbon monoxide, nitrogen oxides, and irritating fumes
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective clothing
Special Procedures: Move containers from fire area if safe. Cool fire-exposed containers with water spray to prevent rupture.
Fire/Explosion Hazards: Non-flammable in solid form, but dust-air mixtures can form explosive atmospheres.
Spill Response: Wear proper personal protective equipment including gloves, goggles, and respirator. Do not touch or walk through spilled material.
Small Spills: Sweep up avoiding creation of dust, place in suitable closed container for disposal.
Large Spills: Evacuate area, ventilate, collect residue using tools which do not produce sparks.
Environmental Precaution: Prevent further leakage if safe. Do not let material enter drains, surface water, or soil.
Decontamination: Wash spill area thoroughly with soap and water after cleanup.
Precautions for Safe Handling: Avoid inhaling dust, prevent contact with skin and eyes. Use in well-ventilated areas. Wash hands after handling.
Hygiene Measures: No eating, drinking, or smoking while handling material. Use dedicated equipment.
Storage Requirements: Keep container tightly closed in a cool, dry, well-ventilated place.
Temperature Sensitivity: Store between 2 – 8°C to preserve stability.
Incompatibilities: Strong oxidizing agents, acids, and bases.
Occupational Exposure Limits: No established limits for norepinephrine tartrate.
Engineering Controls: Use exhaust ventilation or other engineering controls to keep airborne concentrations low.
Personal Protective Equipment (PPE): Chemical-resistant gloves, safety goggles, lab coat. Respirator if dust or aerosols generated.
Environmental Controls: Prevent release into environment via local regulations.
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic aroma
pH (solution): 3.0 – 4.5 in aqueous solution
Melting Point: 242–247 °C (decomposes)
Boiling Point: Not applicable
Solubility: Freely soluble in water; practically insoluble in ethanol and ether
Partition Coefficient log P (octanol/water): -2.1 (calculated)
Vapor Pressure: Not determined
Density: 1.6 g/cm³ (estimated for solid)
Chemical Stability: Stable under recommended storage conditions.
Conditions to Avoid: Heat, moisture, light, incompatible substances such as strong oxidizers.
Decomposition Products: Carbon oxides, nitrogen oxides, irritating and toxic fumes.
Polymerization: Will not occur.
Reactivity: Sensitive to oxidation, may discolour on exposure to air.
Acute Toxicity: LD50 (oral, rat): 60 mg/kg
Skin Corrosion/Irritation: May cause skin irritation or allergic reaction in sensitive individuals.
Serious Eye Damage/Irritation: Causes eye irritation.
Respiratory Sensitization: Prolonged inhalation can cause respiratory tract irritation.
Carcinogenicity: No data indicates carcinogenic risk for humans.
Mutagenicity: No mutagenic effects observed in standard tests.
Reproductive Toxicity: Data not available, avoid contact if pregnant or breastfeeding.
Aquatic Toxicity: Harmful to aquatic organisms even in low concentrations. May cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Moderately biodegradable under environmental conditions.
Bioaccumulative Potential: Low potential for bioaccumulation.
Mobility in Soil: Expected to have moderate mobility in soil.
Other Adverse Effects: Avoid uncontrolled release to environment owing to pharmacological activity.
Product Disposal: Dispose of in accordance with local, regional, and national regulations. Use qualified chemical waste incinerator.
Contaminated Packaging: Rinse containers and dispose as hazardous waste.
Special Precautions: Do not discharge into drains or environment. Consult regulatory authorities for advice on disposal.
UN Number: 2811
Shipping Name: Toxic solid, organic, n.o.s. (contains Norepinephrine tartrate)
Segment: Medical and pharmaceutical chemicals
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Toxic to aquatic life
Special Transport Precautions: Keep containers tightly closed and secure during transport. Avoid temperature extremes and humidity.
Inventory Listing: Listed on relevant chemical inventories
Labelling Requirements: Complies with GHS, OSHA Hazard Communication Standard, and EU CLP Regulation
Workplace Restrictions: Restricted to trained professionals
Other Regulatory Data: Subject to controlled substances and pharmaceutical regulations in some jurisdictions. Carry copies of shipping and handling documentation.
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