Product Name: Norepinephrine Hydrogen Tartrate
Chemical Formula: C8H11NO3·C4H6O6
Synonyms: Levonorepinephrine bitartrate, Arterenol bitartrate
CAS Number: 1199-18-4
Manufacturer: Supplier details and 24-hour emergency contact number should be provided by procurement or facility management.
Recommended Use: Laboratory research and medical-grade applications involving catecholamines.
Restrictions: Only trained personnel under controlled conditions should have access.
Classification: Acute toxicity (Oral, Inhalation), Skin and Eye Irritant
GHS Symbol: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: Harmful if swallowed, Causes skin and eye irritation, May cause respiratory irritation, Target organ effects (cardiovascular, nervous system)
Precautionary Statements: Avoid contact with skin and eyes, Don’t ingest or inhale, Wear suitable protection, Use with adequate ventilation
Health Effects: BP elevation, palpitations, headache, anxiety, tremor, and chest discomfort may occur from excessive exposure
Environmental Effects: Might present some risk to aquatic organisms if released in large quantities
Chemical Name: Norepinephrine hydrogen tartrate
Concentration: >97% pure
CAS Number: 1199-18-4
Impurities: Typical trace-level organic or inorganic salts from synthesis (details vary by manufacturer)
Other Ingredients: This product should not contain additives or stabilizers
Inhalation: Remove from exposure area quickly. Move to fresh air. Administer oxygen if breathing is difficult. Seek medical attention right away.
Skin Contact: Wash skin thoroughly with soap and water for at least 15 minutes. Remove contaminated clothing. Medical attention is recommended.
Eye Contact: Rinse eyes under running water for at least 15 minutes, lifting eyelids occasionally. Get immediate medical care.
Ingestion: Rinse mouth without swallowing, don’t induce vomiting. Seek medical advice at once. Symptomatic treatment only.
Special Treatment: Monitor vital signs closely. Adrenaline and similar drugs may worsen symptoms—products like norepinephrine must be handled with emergency services on call.
Suitable Extinguishing Media: Water spray, dry chemical powder, CO2, alcohol-resistant foam
Fire Hazards: Could decompose to release toxic fumes (nitrogen oxides, carbon monoxide, carbon dioxide)
Fire-fighting Procedures: Full protective suit including self-contained breathing apparatus
Explosion Data: Not sensitive to static discharge, not classified as explosive
Special Hazards: Containers may rupture in fire or direct heat, evacuate area as necessary
Combustion Products: Possible emission of hazardous vapors if heated to decomposition
Personal Precautions: Use gloves, eye protection, and lab coat; avoid creating dust
Emergency Procedures: Evacuate non-essential personnel, ventilate area to prevent dust build-up
Containment: Sweep up without raising dust, use damp cloth or HEPA filter vacuum for fine particles
Cleanup: Collect in suitable container for disposal. Wash area with soapy water.
Environmental Precaution: Prevent from entering drains or environment. Collect spillage for proper disposal.
Handling: Work in fume hood or well-ventilated area. Avoid breathing dust, wear appropriate PPE. Handle away from incompatible materials.
Storage: Cool, dry place in tightly closed container, protected from light. Store away from moisture and large sources of oxidizers.
Conditions to Avoid: Excessive heat, direct sunlight, or humid environments
Incompatibilities: Strong acids, bases, oxidizing agents
Other Info: Keep only in labeled, original containers. Use secondary containment.
Occupational Exposure Limits: No workplace exposure limits established
Engineering Controls: Chemical fume hood, local exhaust ventilation
Personal Protection Equipment (PPE): Chemical-resistant gloves (nitrile recommended), lab coat, safety goggles, and in some circumstances a half-face respirator with HEPA cartridges
Hygiene: Wash hands thoroughly after handling, do not touch face or mouth during work
Environmental Controls: Reduce dust release, avoid environmental contamination
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: 3.0–4.5 (1% solution)
Melting Point: Not less than 140°C
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water, slightly soluble in alcohol
Vapor Pressure: Negligible at room temperature
Density: 1.27 g/cm3 (approximate, literature value)
Stability: Stable in dry, cool storage when sealed from air and light
Partition Coefficient: Not available
Flash Point: Not applicable
Chemical Stability: Stable under recommended handling and storage
Reactivity: May react with strong oxidizers
Hazardous Reactions: Decomposition releases toxic gases
Conditions to Avoid: Heat, flame, light, moisture
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Acute Toxicity: LD50 (oral, rat): 100 mg/kg (literature data, values can vary)
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Potential Health Effects: May affect cardiovascular and nervous system, rapid pulse, high blood pressure, agitation, nausea, vomiting, pallor
Chronic Toxicity: Frequent overexposure might alter blood pressure control, mood disturbances possible due to catecholamine metabolism
Sensitization: Not reported
Carcinogenicity: Not classified by IARC, NTP, OSHA
Mutagenicity and Reproductive Toxicity: Not enough research for categorization, but structurally similar compounds rarely show mutagenic effects at occupational doses
Ecotoxicity: Limited direct toxicity data, but structurally similar compounds can be harmful to aquatic life in large concentrations
Persistence and Degradability: Moderately biodegradable in soil and water
Bioaccumulative Potential: Low
Mobility in Soil: May leach in large spills
Other Information: Discharge to environment may disrupt aquatic organisms, especially at the level that impacts heart or nerve conduction
Waste Disposal: Dispose via licensed chemical waste contractor, follow all local, regional, and national guidelines
Contaminated Packaging: Triple rinse, puncture, and dispose as hazardous chemical waste
Disposal Precautions: Always wear PPE when handling waste, avoid skin and eye exposure, keep away from food and water supplies
Do Not: Discharge into sewer or natural waterways
UN Number: Not regulated under most road, sea, and air regulations but check for regional differences
Proper Shipping Name: Norepinephrine hydrogen tartrate, solid
Hazard Class: Not classified as hazardous by transport regulations
Packing Group: Not assigned
Special Precautions: Protect from moisture, avoid extreme temperatures during transit
Transport Label: Laboratory chemicals, not dangerous goods, mark container clearly
National Inventory Status: Check with local authorities; not always listed as a controlled substance
SARA 313: Not listed
TSCA: Not listed for bulk sale, laboratory use exemption applies
WHMIS Classification: D2B (toxic material causing other toxic effects)
EU Regulation: Not classified as dangerous, but handle under general EU workplace and environmental safety requirements
Labeling Requirements: Must bear cautionary labelling in accordance with relevant regulations to ensure safe handling
Other Regulation: FDA, EMA, or national drug authority restrictions apply for use in humans
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