Chemical Name: Norepinephrine hydrogen tartrate monohydrate
Other Names: Noradrenaline Hydrogen Tartrate Monohydrate
CAS Number: 65-67-4
Recommended Uses: Active pharmaceutical ingredient, laboratory reagent
Supplier: Pharmaceutical suppliers, laboratory chemical distributors
Contact Information: Emergency response phone numbers, supplier address
Physical Hazards: Not classified as explosive, flammable, or oxidizing
Health Hazards: May cause respiratory irritation, allergic skin reaction, or eye irritation on contact; poses risk of cardiovascular changes if ingested or injected
Environmental Hazards: Harmful to aquatic life; run-off or accidental release may impact localized environments
GHS Label Elements: Exclamation mark, health hazard symbols
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation; can impact nervous system; may create allergic dermatitis
Precautionary Statements: Use protective gloves, goggles, dust masks; avoid inhalation, ingestion, and skin contact
Substance: Norepinephrine hydrogen tartrate monohydrate
Chemical Formula: C8H11NO3·C4H6O6·H2O
Synonyms: Noradrenaline tartrate monohydrate
Purity: Greater than 98% by weight
Impurities: Trace levels of moisture, process solvents, residual tars
Ingredients: No other additives or fillers, single component active pharmaceutical ingredient
Inhalation: Remove from exposure site, place in fresh air, seek medical attention for persistent symptoms
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; seek medical guidance in case of rash or irritation
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes; remove contact lenses if present and easy to do; get medical help if irritation persists
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical support
Note to Physicians: Treat symptomatically and monitor cardiovascular function; norepinephrine’s vasoconstrictor effects may require specific guidance in emergencies
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical, foam
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, toxic fumes
Specific Hazards: Thermal decomposition yields irritating and toxic gases
Protective Equipment: Firefighters require self-contained breathing apparatus, protective equipment
Advice for Firefighters: Move containers from fire area if safe, prevent run-off from entering water drains, cool exposed containers with water
Personal Precautions: Ventilate area; use splash goggles, gloves, and dust mask; avoid creating dust clouds
Environmental Precautions: Prevent spillage from entering waterways; contain spills with suitable absorbents
Methods for Cleanup: Sweep up spills, avoid raising dust, place collected material in suitable, sealed, labeled waste containers
Decontamination Procedures: Wash contaminated surfaces with water and detergent; dispose of wash water safely
Notification Requirements: Inform relevant authorities of significant spillage when released into environment
Precautions for Safe Handling: Use in a chemical fume hood; plug all containers securely after use; avoid direct contact with skin, eyes, and clothing
Hygiene Measures: Wash hands before breaks, at shift end, after handling; do not eat, drink, or smoke during use
Storage Conditions: Store in tightly closed containers, protected from light and moisture; maintain low temperature, preferably 2–8°C; segregate away from acids, oxidizers
Incompatibilities: Avoid contact with strong acids, bases, and oxidizers; degradation may occur on exposure to heat or direct sunlight
Specifications for Storage Areas: Use secure, labeled cabinets with restricted access
Occupational Exposure Limits: No established TLV or PEL; minimize exposure through engineering controls
Engineering Controls: Use fume extraction, local ventilation, dedicated laboratory safety systems
Personal Protective Equipment: Laboratory grade latex or nitrile gloves, safety goggles or face shield, disposable lab coat, dust mask or respirator
Special Handling Recommendations: Train personnel in correct handling; keep spill kits, eyewash stations readily available
Appearance: White or off-white crystalline powder
Odor: Odorless
pH (1% solution): 3.0 – 5.0
Melting Point: 95–100°C (decomposes)
Solubility: Freely soluble in water, slightly soluble in ethanol
Partition Coefficient (n-octanol/water): Low; compound is water soluble
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at room temperature
Density: Approximately 1.5 g/cm³
Other Data: Stable under recommended storage conditions
Chemical Stability: Stable if kept out of intense light, dry and cool conditions
Potentially Hazardous Reactions: Reacts with strong oxidants, acids; risk of oxidation with rapid energy release
Materials to Avoid: Acidic or basic materials, oxidizing agents, high temperatures
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, tar residues, unidentified fumes upon decomposition
Conditions to Avoid: Excessive heat, moisture, sunlight, open air
Polymerization: No known hazardous polymerization risk
Acute Toxicity: Oral LD50 (rat): Data limited, low milligram per kilogram range; human exposure through skin or inhalation can cause acute reactions
Skin Irritation: Prolonged or repeated contact may cause rash, allergic dermatitis
Eye Damage: Direct contact stings and irritates eyes
Sensitization: Risk of allergic response after skin exposure
Chronic Exposure: Prolonged exposure to significant amounts can affect central nervous system, cardiovascular health
Carcinogenicity: Not classed as carcinogenic by IARC, NTP, OSHA
Mutagenicity/Teratogenicity: Limited evidence; handle with caution at all times
Aquatic Toxicity: May be toxic to aquatic organisms, particularly at high concentrations or in confined waters
Persistence and Degradability: Likely biodegradable under environmental conditions, but acute release can create local impact
Bioaccumulative Potential: Low due to high water solubility and low lipid solubility
Mobility in Soil: High mobility, can migrate with water flow if spill occurs
Other Adverse Effects: Unintended discharge to water can disrupt biological wastewater treatment plant operation
Disposal Methods: Dispose of residue and contaminated packaging in accordance with local, national, or regional regulations; incinerate in approved chemical waste facility
Special Precautions: Use personal protective equipment when handling waste materials, avoid release to environment
Recycling: Not applicable for this chemical
Transport of Waste: Use sealed, labeled containers; contract hazardous waste vendors as needed
Disposal of Rinsates: Hold all wash and rinse water for processing as hazardous waste
UN Number: Not classified as hazardous for transport under ADR, IATA, or IMDG
Proper Shipping Name: Norepinephrine hydrogen tartrate monohydrate
Transport Hazard Class: Not restricted
Packing Group: Not assigned
Environmental Hazards During Transport: Chemical is not classed as environmentally hazardous for land, sea, or air freight
Special Precautions: Secure packaging, control temperature extremes, use secondary containment for bulk transit
Labelling Requirements: Substance subject to labeling under Globally Harmonized System (GHS); health hazard, exclamation mark pictograms may be required
US Regulation: Not regulated under TSCA, CERCLA, RCRA; active ingredient under FDA controls as prescription drug; handle in accordance with OSHA workplace chemical standards
Europe Regulation: Not classed under REACH Annex XIV or XVII restrictions; included in inventory of existing chemical substances
Other Regulations: Canada DSL/NDSL listed; not a controlled substance under UN conventions; laboratory and pharmaceutical use restrictions apply
Workplace Restrictions: Require controlled access, safety training, record keeping in regulated settings
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