Product Name: Norepinephrine Bitartrate Monohydrate
CAS Number: 34775-55-2
Synonyms: Levonordefrin bitartrate, Arterenol bitartrate
Recommended Use: Pharmaceutical synthesis, research
Manufacturer: Specify supplier details according to procurement source
Emergency Contact: Local poison control center or emergency medical services
Product Code: Specific to institution or batch identification
Hazard Classification: Acute toxicity (oral, dermal, inhalation), Skin sensitization, Eye irritation
GHS Label Elements: Exclamation mark, Health hazard pictograms
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled, causes serious eye irritation, may cause allergic reactions on contact
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective clothing, avoid release into environment
Chemical Name: Norepinephrine Bitartrate Monohydrate
Chemical Formula: C8H11NO3·C4H6O6·H2O
Concentration: 200 mg per unit (100% Norepinephrine bitartrate monohydrate)
Impurities: Trace process chemicals from manufacture may be present; information from batch certificate
Additives: None commonly present unless specified for clinical preparation
Inhalation: Move individual to fresh air, administer artificial respiration if breathing has stopped, consult medical attention immediately
Skin Contact: Remove contaminated clothing, wash affected area with soap and water, seek medical advice if symptoms appear
Eye Contact: Rinse eyes with water for 15 minutes, keep eyelids open during rinsing, consult ophthalmologist
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical personnel, seek medical assistance without delay
Symptoms and Effects: Rapid heart rate, high blood pressure, headache, shortness of breath, anxiety
Suitable Extinguishing Media: Use dry chemical, CO2, water spray, or foam depending on surrounding fire
Specific Hazards: Emits toxic fumes under combustion, such as carbon dioxide, carbon monoxide, nitrogen oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Special Precautions: Move containers away from fire area if it can be done without risk, cool exposed containers with water spray
Personal Precautions: Use appropriate personal protective equipment, ensure proper ventilation, keep unprotected personnel away
Environmental Precautions: Prevent spillage from entering drains, sewers, or waterways, inform proper authorities in case of large spill
Containment Methods: Sweep or scoop up material into suitable container for disposal, avoid dust generation
Clean-Up Procedures: Wash area thoroughly using water and non-reactive detergent, dispose of according to regulatory requirements
Handling: Use in designated chemical laboratory spaces, wear suitable gloves and eye protection, avoid inhalation of dust, handle in fume hood when possible
Storage Conditions: Store below 25°C in tightly closed container, away from heat, moisture, direct light, incompatible substances including acids and oxidizers, segregate from food and animal feed
Special Requirements: Label storage containers clearly, maintain access to safety shower and eyewash station, rotate stock according to expiration date
Exposure Limits: No specific occupational exposure limits established by OSHA, NIOSH, or ACGIH
Engineering Controls: Use local exhaust ventilation, operate in chemical fume hood, monitor workplace air concentrations with appropriate detection devices
Personal Protective Equipment: Wear chemical splash goggles, laboratory gloves resistant to chemicals, lab coat or gown, closed footwear, use NIOSH-approved respirator if expected airborne concentration exceeds comfort levels
Hygiene Measures: Remove contaminated clothing, do not eat or drink while using substance, wash hands thoroughly before breaks and after finishing work
Appearance: White to off-white, crystalline powder
Odor: Odorless
Molecular Weight: 337.3 g/mol
Solubility: Freely soluble in water
Melting Point: Decomposes above 140°C
Boiling Point: Not applicable (decomposes before boiling)
pH (1% solution): Approximately 3–4
Partition Coefficient: Not determined
Other Properties: Sensitive to light, hygroscopic
Chemical Stability: Stable under recommended storage conditions, sensitive to air and light
Possibility of Hazardous Reactions: Reacts with strong oxidizing agents, acids, may decompose at elevated temperatures
Incompatible Materials: Strong oxidizers, acids, bases, peroxides
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides under fire conditions
Acute Toxicity: LD50 (oral, rat) approximately 100 mg/kg
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Rapid heartbeat, rise in blood pressure, nervous system effects such as tremors or sweating, eye and skin irritation
Chronic Effects: Possible sensitization from repeated exposure, no evidence of carcinogenicity in humans
Medical Conditions Aggravated: Cardiovascular disease, hypertension, hyperthyroidism
Ecotoxicity: No data available for direct environmental toxicity, trace discharge into waterways not expected to cause long-term harm
Persistence and Degradability: Readily biodegradable under typical environmental conditions
Bioaccumulation Potential: Not expected to bioaccumulate
Mobility in Soil: Expected to disperse in aquatic environments, high water solubility
Other Adverse Effects: Low risk to aquatic organisms at pharmaceutical discharge levels but limit uncontrolled release
Waste Treatment Methods: Collect waste in sealed, labeled containers, dispose with licensed chemical waste contractor
Incineration: Preferred for pharmaceutical solid wastes under controlled environment following local guidelines
Contaminated Packaging: Decontaminate containers by thorough washing, dispose as chemical waste according to regulations
Regulatory Compliance: Follow national, regional, and local environmental control standards regarding chemical waste disposal
UN Number: Not assigned for this substance in current Dangerous Goods codes
Proper Shipping Name: Norepinephrine bitartrate monohydrate (non-hazardous for transport, not regulated as dangerous goods)
Transport Hazard Class: Non-regulated
Packing Group: Non-assigned
Transport Precautions: Keep tightly sealed, protect from physical damage, avoid extreme temperatures, clearly label shipping container
Special Transport Measures: Ensure compatibility with cargo, avoid storage near food and beverages
TSCA Status: Not listed on United States TSCA inventory due to pharmaceutical use
EU Regulation: Not classified as hazardous under European Regulation (EC) No 1272/2008
SARA Title III: No components subject to reporting
REACH Status: Pre-registered substance for research only
Other Regulation: Depends on country-specific controls and pharmaceutical handling standards, laboratory handling subject to institutional safety protocols, not subject to specific Canadian WHMIS classification
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