Product Name: Norepinephrine Bitartrate Anhydrous
Chemical Name: (-)-Norepinephrine Bitartrate (anhydrous)
Synonyms: Levarterenol bitartrate anhydrous
CAS Number: 39749-68-3
Use: Primarily used as a vasopressor in medicine
Supplier: Pharmaceutical manufacturers, laboratory suppliers
Contact Details: Manufacturer or supplier emergency phone number and address supplied on shipment packaging
GHS Classification: Acute toxicity, oral (category 3); skin and eye irritation (category 2); specific target organ toxicity (single exposure, category 3)
Signal Word: Danger
Hazard Statements: Toxic if swallowed, causes skin irritation, causes serious eye irritation, may cause respiratory irritation
Pictograms: Skull and Crossbones, Exclamation Mark
Precautionary Statements: Avoid breathing dust, wear protective gloves/eye protection, wash thoroughly after handling, avoid contact with eyes, skin, and clothing
Chemical Composition: Norepinephrine bitartrate anhydrous
CAS Number: 39749-68-3
Concentration: Greater than 98% by weight
Impurities: Any residual solvents or synthesis byproducts below established toxicity thresholds
Inhalation: Remove person to fresh air, keep at rest, monitor for respiratory distress, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash affected area thoroughly with soap and water, consult a physician if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, seek medical care for persistent irritation
Ingestion: Rinse mouth, do not induce vomiting, consult a physician immediately
Physician Notes: Treat symptomatically based on exposure and clinical presentation
Suitable Extinguishing Media: Small fires: dry chemical, CO2, water spray, or foam; large fires: water spray or fog
Specific Hazards: Decomposition may release toxic fumes such as carbon oxides and nitrogen oxides
Protective Equipment: Firefighters wear full protective gear and self-contained breathing apparatus
Firefighting Instructions: Move containers from fire area if safe, prevent water runoff from contaminating environment
Personal Protection: Wear suitable protective clothing, gloves, and eye/face protection
Environmental Precautions: Prevent spillage from entering drains or watercourses
Methods for Cleanup: Sweep up or vacuum without creating dust, place material in suitable marked containers for disposal
Decontamination: Wash spill area thoroughly with water after material pickup is complete
Handling: Operate in well-ventilated area, minimize generation and accumulation of airborne dust, avoid contact with skin, eyes, and clothing, practice good hygiene including hand washing before breaks or meals
Storage: Store in tightly sealed original containers in a cool, dry, well-ventilated location, away from incompatible substances (strong oxidizers, acids, or bases), protect from light and moisture, keep out of reach of unauthorized personnel
Occupational Exposure Limits: No established exposure limits specific to norepinephrine bitartrate anhydrous; utilize pharmaceutical industry guidelines for drug handling
Engineering Controls: Laboratory fume hood or equivalent local exhaust recommended during handling
Personal Protective Equipment: Lab coat, impervious gloves, safety goggles
Respiratory Protection: NIOSH-approved respirator for powder handling if ventilation is inadequate
General Safety: Emergency showers and eyewash stations available in immediate area of use
Appearance: White or nearly white, crystalline powder
Odor: Odorless
Molecular Formula: C8H11NO3.C4H6O6
Molecular Weight: 337.3 g/mol
Melting Point: Decomposes above 220°C
Solubility: Freely soluble in water
pH (1% solution): Typically between 3.0–4.0
Partition Coefficient: Data not available
Vapor Pressure: Not applicable
Flashpoint: Not flammable in solid form
Chemical Stability: Stable under recommended storage conditions
Reactivity: No hazardous reactions under normal handling
Hazardous Decomposition Products: Produces toxic gases including carbon oxides and nitrogen oxides upon thermal decomposition
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Conditions to Avoid: Excess heat, moisture, direct sunlight
Acute Oral Toxicity: LD50 (rat): 100 mg/kg (estimate), toxic by ingestion
Acute Inhalation Toxicity: Data not available, treat as hazardous
Acute Dermal Toxicity: Data not available, expected to be harmful
Symptoms of Exposure: Headache, dizziness, sweating, elevated heart rate, anxiety, respiratory distress
Carcinogenicity: Not classified by IARC, NTP, or OSHA
Other Health Effects: Cardiovascular effects, nervous system impacts from excessive exposure
Ecotoxicity: Not expected to be highly toxic to aquatic organisms, but no detailed data available
Persistence and Degradability: Biodegradable under aerobic conditions
Bioaccumulation Potential: Low, based on chemical structure and solubility
Mobility in Soil: Expected to be mobile due to high water solubility
Other Adverse Effects: Prevent large releases into the environment
Disposal Methods: Dispose through licensed chemical disposal contractor, in accordance with federal, state, and local regulations
Packaging Disposal: Triple-rinse empty containers, render unusable before recycling or discarding as hazardous waste
Precautions: Avoid contamination of groundwater, sewers, and waterways, ensure material does not enter general waste streams
UN Number: Not classified as a dangerous good by transport regulations
Transport Hazard Class: Not applicable
Packing Group: Not regulated
Special Precautions: Package securely to prevent breakage or spillage during transit; keep away from food and animal feed
Labeling: Follow applicable labeling requirements based on jurisdiction and intended use
Safety, Health and Environmental Regulations: Subject to pharmaceutical regulations in most jurisdictions; listed in European, US, and Asian pharmacopeias
TSCA Status: Not listed
OSHA Status: Not specifically regulated; general hazard communication applies
SARA Title III: Not considered hazardous under SARA
International Inventories: Check compliance with REACH, WHMIS, or comparable international requirements
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