Product Name: Noradrenalin Bitartrate
Synonyms: Norepinephrine bitartrate, Levarterenol bitartrate
CAS Number: 108341-18-0
Molecular Formula: C8H11NO3.C4H6O6
Recommended Use: Pharmaceutical ingredient for medical use, specifically as a vasopressor
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Classification: Acute toxicity (oral, dermal, inhalation), Hazardous to aquatic environment, Eye irritation
Signal Word: Danger
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause skin allergy, toxic to aquatic life
Pictograms: Exclamation mark, health hazard, environmental hazard
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves and eye protection, avoid release to the environment
Symptoms: Headache, increased heart rate, hypertension, palpitations, respiratory difficulty
Chemical Name: Noradrenalin Bitartrate
Common Name: Norepinephrine bitartrate
PURITY: ≥98%
Impurities affecting toxicity: Potential residues like ethanol, water content
Concentration: 100% (as supplied, refer to certificate of analysis)
Other Ingredients: No significant non-active ingredients in pure bulk powder
Eye Contact: Immediately rinse with plenty of water for at least 15 minutes; seek medical attention promptly
Skin Contact: Remove contaminated clothing, wash affected skin with soap and water; consult a physician if irritation persists
Inhalation: Move person to fresh air, administer artificial respiration if breathing stops, seek immediate medical attention
Ingestion: Do not induce vomiting; rinse mouth with water, give water if conscious, obtain emergency medical help
Notes for Physician: Treat symptomatically, monitor vital signs, consider effects on cardiovascular system
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Special Hazards: Releases toxic fumes of nitrogen oxides, carbon monoxide during combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Firefighting Instructions: Prevent run-off from entering water sources, evacuate downwind personnel
Combustion Products: Carbon dioxide, water vapor, nitrogen oxides, tarry residues
Personal Precautions: Evacuate area, wear protective gloves, safety goggles, suitable mask
Spill Containment: Prevent powder from entering drains, collect with inert absorbent material
Cleanup Procedures: Scoop or sweep up material, place in sealed, labeled waste container, ventilate area
Environmental Precautions: Avoid contamination of soil, surface and ground water
Decontamination: Rinse spill area with water and detergent, prevent further leaks or spills
Handling: Use in well-ventilated areas, avoid skin and eye contact, do not inhale dust or vapors
Safety Practices: Wash thoroughly after handling, do not eat, drink, or smoke near the product
Storage Conditions: Store in original container tightly closed, keep in a cool, dry, dark place
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Special Storage Needs: Protect from moisture, store below 25°C, shield from direct sunlight
Shelf Life: Check expiry date on container
Exposure Limits: No specific occupational exposure limits established
Engineering Controls: Use chemical fume hood and/or local exhaust ventilation
Personal Protective Equipment: Nitrile gloves, safety goggles, disposable lab coats
Respiratory Protection: Use approved respirator if dust or aerosol formation risks exist
Hygiene Practices: Wash hands and forearms thoroughly after handling, remove contaminated clothing
Environmental Controls: Prevent material from reaching soil, waterways, or sewage systems
Appearance: White or off-white crystalline powder
Odor: Odorless
Molecular Weight: 337.27 g/mol
Melting Point: Approximately 200°C (decomposes)
Solubility: Freely soluble in water
pH (1% solution): 3.0 – 5.0
Boiling Point: Not determined (decomposes before boiling)
Vapor Pressure: Not available
Flash Point: Not applicable
Density: Not specified
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Exposure to air, moisture, heat, light
Incompatible Materials: Oxidizing agents, acids, alkalis
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Polymerization: Will not occur
Routes of Exposure: Oral, inhalation, dermal
Acute Toxicity: Harmful if swallowed or absorbed, may be fatal in overdose
Chronic Toxicity: Prolonged exposure may cause cardiovascular and neurological disorders
Irritation: May cause eye, skin, and respiratory irritation
Sensitization: Not known to cause allergenic sensitization in exposed individuals
Mutagenicity/Carcinogenicity: Not classified as mutagenic or carcinogenic based on available data
Signs of Overexposure: Hypertension, arrhythmias, headache, anxiety, difficulty breathing
Aquatic Toxicity: Toxic to aquatic organisms, may cause long-term adverse effects
Mobility in Soil: Not expected to be mobile, binds in soil
Persistence and Degradability: Not readily biodegradable in the environment
Bioaccumulation: Low potential for bioaccumulation
Other Adverse Effects: Disrupts aquatic microbial populations at high concentrations
Waste Disposal Methods: Dispose of discarded substance and containers through a licensed hazardous waste contractor
Container Handling: Triple rinse, puncture, and dispose of empty containers as hazardous waste
Special Precautions: Do not dispose of down household or municipal drains
Legislation: All disposal activities must comply with local, state, and national environmental regulations
UN Number: Not regulated under UN Model Regulation, check with specific carrier
Proper Shipping Name: Noradrenalin bitartrate
Transport Hazard Class: Not classified as dangerous for transport by road, sea, or air
Packing Group: Not applicable
Special Precautions: Package securely, prevent breakage, avoid extreme temperatures
Label Requirements: Use appropriate chemical label, mark as pharmaceutical precursor
TSCA Status: Listed/Restricted in some localities
FDA/EMA Status: Approved drug substance (subject to pharmaceutical laws)
OSHA Hazard Communication: Classified as hazardous chemical
Environmental Regulation: Subject to Chemical Safety Assessment under REACH (Europe)
SARA Title III: Not classified as extremely hazardous
Other: Product use governed by regional, national, and international pharmaceutical and chemical safety regulations
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