Product Name: Noradrenaline Tartrate
Chemical Name: (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, tartrate (1:1)
CAS Number: 108341-18-0
EC Number: 203-02-9
Synonyms: Norepinephrine tartrate, L-Arterenol tartrate
Recommended Use: Pharmaceutical agent, research chemical
Manufacturer: Refer to label, includes emergency contact information and supplier address
Emergency Contact: Local Poison Control Center or company emergency telephone number
GHS Classifications: Acute toxicity (oral, category 4), skin irritation (category 3), serious eye damage/irritation (category 2A), specific target organ toxicity-single exposure (category 3)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark (GHS07)
Precautionary Statements: Avoid breathing dust, wash hands after handling, use only outdoors or in well-ventilated area, if exposed or concerned: get medical advice/attention
Other Hazards: Not combustible, dust may form explosive mixture in air under extreme conditions
Chemical: Noradrenaline Tartrate
CAS Number: 108341-18-0
Percent (%) by Weight: 99% or greater
Impurities/Other Ingredients: Hydration water, residual solvents below permitted levels, trace inorganic salts
Formula: C8H11NO3·C4H6O6
Molecular Weight: 337.3 g/mol
Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes, remove contact lenses if present, seek medical attention promptly
Skin Contact: Wash off with soap and water, remove contaminated clothing, seek medical attention if irritation persists
Inhalation: Move to fresh air, monitor for respiratory distress, give oxygen if breathing is difficult, seek medical advice immediately
Ingestion: Rinse mouth thoroughly with water, do not induce vomiting, seek medical help without delay
Important Symptoms: Sympathetic nervous system stimulation, palpitations, hypertension, anxiety
Advice for Medical Professionals: Standard supportive care, monitor vital signs, treat symptomatically, be aware of potential cardiovascular complications
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Media: High volume water jet may spread material
Specific Hazards: Product is not flammable, may emit toxic fumes under combustion (carbon monoxide, nitrogen oxides)
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Special Procedures: Evacuate area, prevent runoff from entering water sources, cool containers exposed to fire with water spray
Explosion Hazard: No explosive properties noted under normal use
Personal Precautions: Evacuate unnecessary personnel, avoid dust generation, use personal protection
Protective Equipment: Chemical-resistant gloves, goggles, lab coat, NIOSH-approved respirator for dust
Environmental Precautions: Prevent entry to sewers, soil, and waterways, report spills to authorities as required
Cleaning Methods: Sweep up material carefully, avoid raising dust, place in appropriate closed waste container, wash spill area with water and detergent
Emergency Procedures: Ventilate area, follow institutional spill response protocol
Handling Precautions: Handle in a chemical fume hood or well-ventilated area, avoid ingestion, inhalation, and contact with eyes and skin, use appropriate PPE, keep containers tightly closed
Storage Requirements: Store in a cool, dry, well-ventilated area, protect from light, segregate from strong oxidizers, acids, and bases, maintain temperature between 2–8°C, store in original container
Incompatible Materials: Strong oxidizing agents, alkaline materials
Storage Class/Code: Pharmaceutical substance, store according to institutional and legal requirements
Exposure Limits: No specific occupational exposure limits established
Engineering Controls: Local exhaust ventilation, safety shower, eyewash station in immediate vicinity
Personal Protective Equipment: Safety goggles, gloves (nitrile or latex), lab coat, respiratory protection if dust is generated
Hygiene Measures: Wash hands before eating and after handling, avoid touching face, remove contaminated clothing promptly
Special Sensitivity Measures: Protection for sensitive or pregnant staff
Appearance: White or slightly off-white crystalline powder
Odor: Odorless
pH (solution): 3 - 5 (1% aqueous solution)
Solubility: Freely soluble in water, sparingly soluble in ethanol
Melting Point: 210°C (decomposes)
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not applicable
Partition Coefficient (log Pow): Not determined
Density: Approx. 1.39 g/cm³
Flash Point: Not required (non-flammable solid)
Chemical Stability: Stable under recommended conditions, sensitive to moisture and light
Reactivity: Reacts with strong oxidizers, may degrade in alkaline environments
Possibility of Hazardous Reactions: None expected under normal handling
Conditions to Avoid: Excessive heat, light exposure, moisture, incompatible substances
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides if combusted
Acute Toxicity: Oral LD50 (rat) approximately 100 mg/kg (literature data)
Skin Corrosion/Irritation: May cause mild irritation
Serious Eye Damage/Irritation: May cause moderate to severe irritation
Respiratory or Skin Sensitization: Not a known sensitizer, but repeated exposure can cause hypersensitivity
Germ Cell Mutagenicity: No data indicating mutagenic potential in humans
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Reproductive Toxicity: Animal studies suggest possible developmental toxicity at high doses
Symptoms/Effects: Palpitations, elevated blood pressure, anxiety, headache, sweating, agitation
Chronic Effects: Frequent exposure may induce cardiovascular stress
Ecotoxicity: Toxic to aquatic organisms at higher concentrations
Persistence and Degradability: Expected to be biodegradable under aerobic conditions
Bioaccumulative Potential: Low, unlikely to persist in biological systems
Mobility in Soil: Water soluble, may leach to groundwater
Other Adverse Effects: No evidence of significant environmental hazard in usual laboratory use
Disposal Methods: Dispose of as hazardous chemical waste, follow local, regional, and national regulations
Contaminated Packaging: Rinse containers, dispose with hazardous waste
Sewage Disposal: Release to sewers or waterways not permitted
Special Precautions: Handle residues and non-decontaminated packaging as hazardous material
Waste Codes: Consult local regulations as substances used in pharmaceutical production often fall under specific waste codes (e.g., US EPA hazardous waste: U-listed)
UN Number: Not classified as hazardous for transport (ADR/RID, IMDG, IATA)
Proper Shipping Name: Not regulated
Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions: Avoid release to the environment during handling and transport, use secure packaging to prevent leaks
Regulations: Subject to pharmaceutical and laboratory chemical safety regulations, may be listed on local chemical inventories
Labelling Requirements: GHS compliant labels including hazard pictograms, signal words, and precautionary measures
OSHA Status: Not regulated as a hazardous material, typical chemical handling rules apply
TSCA/DSL: Listed or exempt
Other Regulation Notes: Must comply with DEA and FDA regulations in the US for prescription and controlled drugs, check national legislation for workplace and environmental health standards
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