Product Name: Noradrenaline, tartrate (1:1)
Chemical Formula: C8H11NO3·C4H6O6
Synonyms: Norepinephrine bitartrate, Levarterenol tartrate
CAS Number: 108341-18-0
Recommended Use: Laboratory chemicals, pharmaceutical manufacture
Supplier Contact Information: Emergency telephone, address, manufactured or distributed by major chemical suppliers and handled in controlled settings to avoid unauthorized access
Emergency Overview: White to off-white powder, slight odor, molecule is sensitive to light and air, intended for trained personnel only
GHS Classification: Acute toxicity, Category 3 (oral); Eye irritation, Category 2A; Skin sensitizer, Category 1
Signal Word: Danger
Hazard Statements: Toxic if swallowed, causes serious eye irritation, may cause allergic skin reaction
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves, clothing, eye and face protection
Potential Health Effects: Rapid heartbeat, elevated blood pressure, headache, nervous system impact, irritation to eyes, respiratory system, or skin upon exposure
Environmental Hazards: Harmful to aquatic life with long lasting effects, avoid release to environment
Chemical Name: Noradrenaline, tartrate (1:1)
CAS Number: 108341-18-0
Concentration: 99-100%
Impurities: Trace organic or inorganic byproducts under 1% in certified lab samples
Molecular Weight: Approximately 337.3 g/mol
Inhalation: Move individual to fresh air, seek medical attention for breathing difficulty, assist with artificial respiration if needed
Skin Contact: Remove contaminated clothing, thoroughly wash skin with soap and water, seek medical advice if irritation or allergic reaction arises
Eye Contact: Rinse eyes with water for at least 15 minutes, remove contact lenses, get medical help immediately, avoid rubbing eyes
Ingestion: Do not induce vomiting, rinse mouth with water, immediately call a poison center or healthcare provider
Most Important Symptoms: Rapid heart rate, headache, high blood pressure, nausea, agitation, risk of cardiovascular events
Advice for Physicians: Administer supportive and symptomatic care, monitor vital signs, secure airway for severe reactions
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Hazards: Material decomposes during fire to release toxic and irritating vapors like carbon oxides, nitrogen oxides, and tartrate byproducts
Protective Equipment and Precautions: Firefighters use self-contained breathing apparatus, full protective gear, avoid inhaling combustion products
Special Firefighting Procedures: Move containers away from fire area if safe, use extinguishing agents based on surrounding fire, avoid run-off into environment
Personal Precautions: Evacuate unnecessary personnel, wear chemical splash goggles, gloves, laboratory coat, and appropriate respiratory protection
Environmental Precautions: Prevent further leakage or spillage, avoid discharge into drains, surface water or soil
Methods for Clean Up: Sweep up with minimal dust, place in well-labeled container for disposal, ventilate area, decontaminate spill site with detergent and water, dispose of cleanup materials as hazardous waste
Advice for Emergency Responders: Use containment, avoid exposure, notify authorities about larger releases
Handling: Use inside chemical fume hood, minimize dust generation, avoid direct contact with skin, eyes, and clothing, do not eat or drink in workspace, wash thoroughly after handling
Storage: Store in tightly closed container, in a cool, dry, well-ventilated place, protect from light, segregate from incompatible materials like oxidizers or acids, label containers clearly, provide restricted access for authorized personnel only
Engineering Controls: Chemical fume hood or local exhaust ventilation, eyewash stations and safety showers close to areas of use
Personal Protective Equipment: Chemical-resistant gloves (such as nitrile), goggles or face shield, laboratory coat, dust mask or air-purifying respirator when dust or aerosols risk is present
Exposure Limits: No specific OSHA, ACGIH, or NIOSH exposure limits set for noradrenaline tartrate, standard industrial hygiene practices apply
Hygiene Measures: Wash hands before breaks, after handling, and at end of shift, avoid cross-contamination between workspace and communal areas, ensure contaminated clothing is laundered before reuse
Appearance: Fine white to off-white crystalline powder
Odor: Slight, characteristic
Odor Threshold: Not determined
pH: 2.5 – 4.5 (1% solution)
Melting Point/Range: 207–212°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not flammable
Evaporation Rate: Not determined
Flammability: Not classified as flammable
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Solubility: Soluble in water, sparingly soluble in alcohol, insoluble in ether
Partition Coefficient (n-octanol/water): Data not available
Decomposition Temperature: Above melting point, releases toxic gases
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions, decomposes in presence of light and air
Possibility of Hazardous Reactions: May react with strong oxidizers
Conditions to Avoid: Exposure to heat, moisture, direct sunlight, incompatibles
Incompatible Materials: Strong oxidizing agents, acids, alkalis, iron salts
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, tartrate breakdown products
Acute Toxicity - Oral: LD50 (rat) estimated at 50-200 mg/kg (considered toxic)
Acute Toxicity - Dermal: Data not specified, minimize direct skin contact
Skin Irritation/Corrosion: May cause skin irritation and allergic reactions
Eye Damage/Irritation: Causes serious eye irritation
Respiratory Sensitization: Inhalation may cause respiratory tract irritation and symptoms of central nervous system stimulation
Repeated Dose Toxicity: Risk of cardiovascular complications—high blood pressure, arrhythmias, headache, nausea, agitation
Carcinogenicity: Not classified as carcinogen by IARC, OSHA, NTP
Mutagenicity: No significant mutagenic effects reported
Reproductive Toxicity: Effects on fetus not fully documented, avoid exposure if pregnant
Potential Symptoms: Palpitations, hypertension, restlessness, headache, in severe cases collapse or shock
Chronic Effects: Prolonged or repeated exposure may affect heart, blood pressure regulation, central nervous system
Ecotoxicity: Acute aquatic toxicity data limited, potential hazard to aquatic species, minimize entering waterways
Persistence and Degradability: Likely persists if released, breakdown dependent on environmental factors and microbial action
Bioaccumulative Potential: Not expected to bioaccumulate significantly, but effects on aquatic organisms possible
Mobility in Soil: Water solubility indicates possible movement in soil, higher risk of reaching groundwater in case of spills
Other Adverse Effects: Impact on wastewater treatment processes unclear, avoid uncontrolled disposal
Waste Handling: Treat as hazardous chemical waste, store in labeled, sealed containers
Disposal Methods: Incinerate in licensed facility, avoid landfill disposal, comply with regional, local, national, and international regulations
Contaminated Packaging: Dispose of containers or surplus material as hazardous waste after thorough emptying and cleaning
Precautions: Prevent material and solutions from entering watercourses, inform disposal personnel about hazards
UN Number: 2811 (Toxic solids, organic, n.o.s.)
Proper Shipping Name: Toxic solid, organic, n.o.s. (Noradrenaline tartrate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Labels Required: Toxic substance, keep away from foodstuffs, do not allow accidental release
Additional Information: Protect from physical damage and extreme temperatures during transit, comply with IATA, IMDG, and DOT guidelines on hazardous materials
OSHA: Considered hazardous based on classification criteria
TSCA: Listed or regulated, check status for commercial/import use
EU Regulation (REACH): Subject to restrictions under hazardous substances regulations, safety data sheet should be provided to downstream users
SARA Title III: Not subject to sections 302, 304, 313 reporting, but storage and handling may require local notification
Other National Regulations: Compliance with workplace exposure limits and employee training requirements essential, registration may be necessary for medical or research uses based on jurisdiction
Transport Regulations: Classified as hazardous for shipping by land, air, and sea, dedicated documentation required for lawful transport
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