Product Name: Noradrenaline Bitartrate
Synonyms: Norepinephrine Bitartrate, L(-)-Arterenol bitartrate
CAS Number: 62-31-7
Molecular Formula: C8H11NO3·C4H6O6
Recommended Use: Pharmaceutical ingredient; critical care vasopressor
Supplier Information: Provided by licensed pharmaceutical manufacturers and distributors
Emergency Telephone: Refer to local poison control and chemical incident numbers
GHS Classification: Acute Toxicity – Oral (Category 3), Acute Toxicity – Dermal (Category 3), Eye Irritant (Category 2)
Signal Word: Danger
Hazard Statements: Toxic if swallowed or in contact with skin; Causes serious eye irritation
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Avoid breathing dust; Wash hands thoroughly after handling; Do not eat, drink or smoke when using this product; Wear protective gloves and eye protection
Other Hazards: Rapid absorption; Risk to cardiovascular health in vulnerable individuals; Decomposition may generate hazardous fumes
Chemical Name: Noradrenaline Bitartrate
Concentration: ≥98% pure
Ingredients: Noradrenaline base (active pharmaceutical), Tartaric Acid as counterion
Impurities: Trace amounts from manufacturing process, typically less than 1%
Additives: May include stabilizers or buffers in formulated products
Inhalation: Move affected person to fresh air quickly; monitor for respiratory distress or palpitations; seek immediate medical attention
Skin Contact: Remove contaminated clothing; wash thoroughly with soap and water; get medical help if irritation, redness or symptoms persist
Eye Contact: Rinse cautiously with water for at least 15 minutes; remove contact lenses if easy and continue rinsing; obtain medical care
Ingestion: Never induce vomiting; rinse mouth, do not administer anything by mouth to an unconscious person; seek urgent medical help—risk of acute toxicity and cardiovascular effects
Symptoms to Watch: Palpitations, hypertension, arrhythmia, sweating, confusion, headache, tremors
Suitable Extinguishing Media: Use dry chemical, CO2, water spray or foam for small fires; avoid direct water stream to minimize chemical spread
Unsuitable Extinguishing Media: Do not use high-pressure water jets
Specific Hazards: Product combustion may emit nitrogen oxides, carbon oxides, irritating vapors
Special Protective Equipment: Firefighters require self-contained breathing apparatus and full protective clothing
Additional Advice: Control runoff water to prevent environmental contamination, and approach fire from upwind position
Personal Precautions: Evacuate unnecessary personnel; ventilate the area; use appropriate personal protective equipment including gloves and safety eyewear
Environmental Precautions: Prevent entry to sewers, surface water, or soil; inform authorities of significant spillage or contamination
Spill Cleanup Methods: Absorb spill with an inert material; collect and place in clearly labeled container for disposal; decontaminate with suitable disinfectant
Exposure Controls: Limit inhalation and dermal exposure; restrict work until area is cleaned thoroughly
Handling: Avoid contact with skin, eyes, and clothing; prevent inhalation of powders; handle only in well-ventilated areas; do not ingest or allow contamination of surfaces
Storage: Store in tightly closed containers at controlled room temperature (15–25°C), protected from light and moisture; segregate from incompatible substances, oxidizers, and acids
Stability Concerns: Light and heat degrade product; inspect regularly for integrity of packaging
Special Instructions: Reserve use and access for trained personnel; maintain accurate inventory records
Control Parameters: No official workplace exposure limits; minimize exposure to dust and aerosols
Engineering Controls: Use within fume hood or ventilated enclosure; adopt closed processes where feasible; employ local exhaust ventilation
Personal Protective Equipment: Gloves, chemical-resistant lab coats, splash goggles or face shield; positive pressure respirators for high concentrations or emergencies
Hygiene Measures: Wash hands after handling; do not eat, drink, or smoke during use; remove contaminated clothing promptly
Appearance: White to light beige crystalline powder
Odor: Odorless
Solubility: Freely soluble in water
Melting Point: 220–225°C (decomposition)
pH (aqueous solution): 3.0–4.5
Molecular Weight: 337.3 g/mol
Boiling Point: Decomposes before boiling
Other Properties: Stable under recommended storage; sensitive to light, air, and heat
Chemical Stability: Stable under designated conditions; degrades under exposure to extreme temperature or light
Hazardous Reactions: Reacts with oxidizing agents; generates nitrous gases and carbon oxides during decomposition
Conditions to Avoid: Moisture, direct sunlight, elevated temperatures
Incompatible Materials: Strong acids, oxidizers, bases, some metals
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, other hazardous fumes
Acute Toxicity: Toxic if swallowed, inhaled, or in contact with skin (LD50 oral/rat: ~100 mg/kg)
Chronic Effects: Long-term or repeated exposure causes nervous system, cardiovascular or hypertensive symptoms
Potential Symptoms: Nausea, headaches, heart palpitations, sweating, tremors, risk of arrhythmias or hypertensive crisis
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Sensitization: May cause allergic reactions with repeat exposure in some individuals
Reproductive Effects: Data limited, avoid unnecessary exposure during pregnancy or lactation
Other Data: High doses risk rapid blood pressure elevation, dangerous for those with cardiovascular disease
Ecotoxicity: Expected to be hazardous to aquatic organisms at high concentrations; persistent residues may disrupt aquatic and soil microorganism activity
Mobility: Readily soluble in water; migration through soil possible
Persistence and Degradation: Slowly biodegradable; may persist in environmental compartments if disposed in bulk
Bioaccumulation: Unlikely due to water solubility and rapid metabolic breakdown in organisms
Other Adverse Effects: At concentrated spills, potential for toxic effects on local wildlife and surface water systems
Waste Treatment Methods: Dispose as hazardous pharmaceutical waste using licensed incineration or chemical destruction protocols
Contaminated Packaging: Triple-rinse and puncture before landfilling or incinerating; avoid reuse for other applications
Special Precautions: Do not discard in domestic waste or pour into drains, watercourses, or soil
Local Regulations: Follow country, regional and municipal rules for pharmaceutical or laboratory chemical disposal
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Noradrenaline Bitartrate)
Transport Hazard Class: Class 6.1 (Toxic substances)
Packing Group: III (lower degree of danger)
Labels: Toxic (skull and crossbones symbol)
Special Precautions: Protect containers from physical damage and environmental exposure during shipment; follow documentation and labeling rules
Marine / Air Transport: Regulated by IATA and IMDG guidelines
Labelling Requirements: Adhere to local GHS, OSHA, CLP, and national pharmaceutical labeling rules
Inventory Status: Listed in relevant chemical inventories where authorized (FDA, EMA, etc.)
Workplace Controls: Regulated use in pharmaceutical and laboratory settings only, with restricted access
Environmental Restrictions: Registered as hazardous in waste management guidelines; subject to chemical emissions and transport regulations
User Responsibilities: Employers must assure training in safe handling, emergency measures, and recordkeeping for exposure or incident
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