Product Name: Noradrenaline Bitartrate Monohydrate
Chemical Synonyms: Norepinephrine bitartrate monohydrate
Molecular Formula: C8H11NO3·C4H6O6·H2O
Molecular Weight: 337.3 g/mol
Recommended Use: Laboratory chemical, research, pharmaceutical ingredient
Manufacturer Details: Chemical supplier or pharmaceutical company contact information, emergency contact number, address of manufacturer, e-mail for reporting safety inquiries, customer support phone
Classification: Acute toxicity (oral, dermal, inhalation), corrosive to eyes and skin
GHS Label Elements: Danger pictograms, signal word DANGER, hazard statements for acute toxicity and skin/eye irritation
Hazards: Harmful if swallowed, causes skin and serious eye damage, may cause allergic skin reaction, harmful if inhaled
Other: Can cause rapid heartbeat, high blood pressure, and central nervous system effects at high doses; avoid unnecessary exposure
Main Ingredient: Noradrenaline bitartrate monohydrate
CAS Number: 38669-82-8
EC Number: 253-351-1
Purity: >98% pure by HPLC
Impurities: Trace residual solvents or reaction byproducts (fewer than 0.2%)
Inhalation: Move affected person to fresh air, seek medical attention for difficulty breathing
Skin Contact: Rinse skin immediately with plenty of water, remove contaminated clothing, continue rinsing 15 minutes or more, medical supervision as needed
Eye Contact: Rinse eyes with running water for 20 minutes holding eyelids open, remove contact lenses if present, seek prompt medical evaluation
Ingestion: Rinse mouth, do not induce vomiting, seek immediate physician evaluation
Notes to Physician: Treat symptomatically, monitor cardiac function closely, sodium bicarbonate can help counter metabolic acidosis, maintain airway and oxygenation
Suitable Extinguishing Media: Use water spray, dry powder, carbon dioxide, or foam
Unsuitable Extinguishing Media: Direct water jet can spread powder
Special Exposure Hazards: Harmful decomposition products like carbon monoxide, carbon dioxide, nitrogen oxides, toxic fumes may form
Firefighter Protective Equipment: Full-body fire protection suit and self-contained breathing apparatus
Additional Notes: Avoid inhaling fumes, evacuate area, keep containers cool with water spray
Personal Precautions: Use chemical splash goggles, respirator mask, gloves, lab coat
Environmental Precautions: Prevent entry to soil, drains, surface water
Spill Cleanup Procedures: Sweep or shovel up without generating dust, place in labeled, sealed waste packaging for disposal, ventilate and clean spill area with water
Decontamination: Spray surfaces with detergent solution, wipe up with disposable towels
Waste Handling: Dispose of as hazardous chemical waste in accordance with local regulations
Handling: Use in fume hood, avoid ingestion or contact with skin, eyes, avoid inhalation of dust, wash hands before eating, after handling, keep container closed
Storage Conditions: Store locked up in original tightly closed containers, away from incompatible materials, in a cool, dry, well-ventilated area, protect from light and moisture
Incompatible Materials: Strong oxidizing agents, acids, bases
Specific End Uses: Laboratory application, active pharmaceutical ingredient, not for food or feed use
Exposure Limits: No established occupational exposure limits; minimize exposure as best practice
Engineering Controls: Well-ventilated workspace, chemical fume hood, closed processes
Personal Protection: Chemical-resistant gloves (nitrile), goggles or safety glasses, lab coat, vapor mask with NIOSH-approved filters for dusts
Hygiene Measures: No eating, drinking, or smoking in work area, wash hands and face before leaving lab, remove soiled clothing
Environmental Controls: Avoid release to the environment, dispose of waste responsibly
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Approximately 3-5 (1% solution in water)
Melting Point: 237–242°C (decomposes)
Solubility: Freely soluble in water, practically insoluble in ethanol, ether, chloroform
Vapor Pressure: Negligible at ambient temperature
Density: Not applicable (solid powder)
Partition Coefficient (log Po/w): Not determined
Decomposition Temperature: Decomposes at high heat with release of hazardous gases
Chemical Stability: Stable under normal storage and handling conditions, can degrade under exposure to light, air, and humidity
Possible Hazardous Reactions: Reacts with oxidizers producing toxic fumes
Conditions to Avoid: Direct sunlight, excess heat, air exposure, moisture
Incompatible Materials: Acids, alkalis, strong oxidizing substances
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, toxic fumes
Acute Toxicity (Oral): LD50 (rat) ~94 mg/kg
Acute Toxicity (Dermal, Inhalation): Data limited; treat as potentially harmful
Skin Irritation: May cause irritation, redness, and allergic reactions
Eye Damage: Severe irritation, possible corneal injury
Respiratory Impact: Dust inhalation: cough, headache, rapid heartbeat, central nervous system stimulation
Long-Term Effects: Potential risk of cardiac arrhythmias, hypertension
Sensitization: May develop skin or respiratory allergy symptoms
Other Chronic Effects: Effects not fully studied; avoid repeated exposure
Ecotoxicity: May be toxic to aquatic organisms, data insufficient for full hazard classification
Persistence and Degradability: Not readily biodegradable, may persist in environment
Bioaccumulation Potential: Expected to have low bioaccumulation, but data incomplete
Mobility in Soil: Soluble, could leach to groundwater if released
Other Adverse Effects: Release to waterways should be avoided, effect of breakdown products on ecosystems unknown
Waste Treatment Methods: Treat as hazardous chemical waste, incineration or chemical disposal according to local, state, national regulations
Contaminated Packaging: Dispose as hazardous waste, do not reuse containers
Special Precautions: Do not dump in drains, surface water, or general refuse, hand over to licensed disposal contractor
Recommended Disposal: Chemical incinerator with afterburner and scrubber for emissions
UN Number: Not regulated under major international transport codes
UN Proper Shipping Name: Not assigned
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not classified as marine pollutant, minimize spill risk
Special Precautions for Transport: Keep containers tightly sealed, transport in secondary containment where possible, only dedicated, trained personnel
Mode of Transport: Ground/air/sea, subject to company’s internal procedures
EU Regulations: Component listed on EC inventory, observe workplace safety regulations
US Regulations: Product not listed as hazardous under SARA, CERCLA, or TSCA, subject to OSHA laboratory safety standard
Chemical Inventory Status: Present on relevant chemical inventories (REACH, TSCA, EINECS)
Labeling Requirements: Use GHS-compliant labels indicating hazard statements and precautionary pictograms
Other Regulations: Follow all national and international regulations for pharmaceutical and chemical handling, inform local safety authority about storage amounts if required
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