Product Name: Noradrenalin Bitartrate
Synonyms: Norepinephrine bitartrate, Arterenol bitartrate, Levophed bitartrate
CAS Number: 108341-18-0
Recommended Use: Pharmaceutical ingredient, research chemical
Manufacturer: Refer to supplier or laboratory of origin
Contact Information: Emergency contact and standard number provided by supplier
Product Code: Identifiable by laboratory or catalog number
Emergency Phone: Refer to local or supplier emergency protocols
GHS Classification: Acute toxicity (oral, dermal, inhalation), specific target organ toxicity, eye irritation, skin sensitization
Signal Word: Danger
Hazard Statements: Harmful if swallowed, may cause allergic skin reaction, causes serious eye irritation, may cause respiratory irritation, may affect cardiovascular system
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Avoid breathing dust or vapors, wear gloves and eye protection, wash hands thoroughly after handling, avoid release to environment
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Target Organs: Cardiovascular system, central nervous system, eyes, skin
Potential Health Effects: Elevated blood pressure, rapid heartbeat, headache, tremor, anxiety, pallor, necrosis at injection site
Chemical Name: Noradrenalin Bitartrate
Molecular Formula: C8H11NO3·C4H6O6
Molecular Weight: 337.29 g/mol
PURITY: Typically >98% (verify with laboratory data sheet)
Ingredient Percentage: Noradrenalin bitartrate 100% by weight
Additives or Impurities: No significant additives or stabilizers present in pure substance
Other Identifiers: EC Number 200-014-1, UN Number 2811 (toxic solid, organic, n.o.s. classification may apply)
Skin Contact: Remove contaminated clothing, rinse skin with water for at least 15 minutes, seek medical attention if irritation develops
Eye Contact: Immediately flush eyes with water for 15 minutes, lift eyelids occasionally, get prompt medical evaluation
Inhalation: Move person to fresh air, provide oxygen if breathing is difficult, keep warm and at rest, get medical attention
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical advice, monitor for symptoms of cardiovascular distress
Most Important Symptoms: Hypertension, palpitations, headache, skin sensitization, local necrosis
Immediate Medical Attention Needed: Yes, after significant exposure or upon onset of symptoms
Suitable Extinguishing Media: Use dry chemical, foam, or carbon dioxide for small fires; water spray for larger fires
Hazards from Combustion Products: Releases toxic fumes, including nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Wear full protective clothing, self-contained breathing apparatus, gloves, eyewear
Special Procedures: Cool containers with water spray, evacuate area if fire becomes uncontrollable
Unusual Fire/Explosion Hazards: Fine dust may form explosive mixtures with air; handle and store with good ventilation to prevent dust accumulation
Personal Precautions: Evacuate personnel, avoid breathing dust, provide adequate ventilation, use personal protective equipment
Environmental Precautions: Prevent leak or spill from entering drains, watercourses, or soil
Clean-Up Methods: Sweep up using methods minimizing dust generation, place in sealed containers for disposal, decontaminate area with detergent solution
Protective Measures: Wear disposable gloves, gown, mask, goggles; avoid contact with skin, eyes, and clothing
Emergency Procedures: Isolate area, ventilate, and prevent further spillage or dust formation
Safe Handling: Handle in accordance with laboratory safety procedures, avoid inhalation and skin or eye contact, use inside fume hood
Technical Precautions: Implement local exhaust ventilation, use with tools designed to limit static generation
Storage Conditions: Store tightly closed in designated chemical refrigerator, protect from light, moisture, and incompatible materials such as strong bases and oxidizing agents
Storage Temperature: 2–8°C, avoid freezing unless specified by supplier
Packaging Materials: Keep in original, labeled containers or chemical-safe vials
Incompatibilities: Strong oxidizers, strong bases
Specific End Uses: Restricted to laboratory, medical, or research use only; not for use in food, drug, or household products
Exposure Limits: No established occupational exposure limits; minimize exposure as much as possible
Engineering Controls: Use fume hood, local exhaust ventilation, maintain negative pressure where feasible
Personal Protective Equipment: Chemical-resistant gloves (nitrile or latex), lab coat or apron, chemical splash goggles, face shield if risk of splash
Respiratory Protection: Use NIOSH-approved dust mask or respirator for high concentrations or accidental releases
Other Hygiene Measures: Wash hands thoroughly after handling, do not eat or drink in work area, remove contaminated clothing and clean before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless or faint medicinal odor
Odor Threshold: Not established
pH (solution): ~3.0–5.0 (1% aqueous solution)
Melting Point: 225–230°C (decomposition may occur before melting)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not applicable/not available
Solubility: Soluble in water, slightly soluble in alcohol
Vapor Pressure: Not available; expected to be negligible at room temperature
Density: Approximately 1.5 g/cm³
Partition Coefficient (log Kow): Not determined (hydrophilic compound)
Viscosity: Not applicable to solid
Auto-Ignition Temperature: Not established
Decomposition Temperature: Above 225°C
Evaporation Rate: Not applicable
Chemical Stability: Stable under recommended storage conditions, sensitive to light and moisture
Conditions to Avoid: Exposure to light, prolonged exposure to air, high temperatures
Incompatible Materials: Strong oxidizing agents, strong bases, reducing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, possibly toxic organic compounds
Hazardous Reactions: May react with oxidizers, avoid contact to prevent hazardous decomposition
Polymerization: Will not occur under normal use conditions
Routes of Entry: Skin, inhalation, ingestion, eyes
Acute Toxicity: Oral rat LD50: 100 mg/kg (estimated based on norepinephrine data), more toxic intravenously
Skin Irritation: Causes skin sensitivity and possible local necrosis on prolonged contact
Eye Irritation: Causes severe irritation, tearing, possibly corneal injury
Respiratory Effects: May cause shortness of breath, chest pain, cardiovascular distress
Long-Term Exposure: Effects on cardiovascular system, potential nervous system changes, possible sensitization
Carcinogenicity: Not listed as carcinogen by OSHA, IARC, or NTP
Mutagenicity: No significant data for mutagenic effects
Reproductive Toxicity: No significant data in humans
Ecotoxicity: Potentially toxic to aquatic organisms, use care in disposal
Persistence and Degradability: Expected to degrade in the environment, but breakdown may be slow in water and soil
Bioaccumulative Potential: Not expected to bioaccumulate due to low partition coefficient and solubility profile
Mobility in Soil: Mobile due to water solubility, risk to groundwater if released
Other Adverse Effects: Discharge to environment should be avoided, especially near water sources or sensitive areas
Waste Disposal Methods: Dispose of by incineration at licensed hazardous waste facility, in accordance with federal, state, and local regulations
Container Disposal: Triple rinse, deface label, dispose as hazardous waste
Precautions: Do not discharge to sewer or natural waterway, avoid landfill wherever possible
Additional Advice: Consult local environmental authorities for restrictions and reporting requirements
UN Number: 2811 (toxic solid, organic, n.o.s. – verify based on shipping method)
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains noradrenalin bitartrate)
Transport Hazard Class: 6.1 (toxic substances)
Packing Group: III (moderate hazard)
Hazard Labels: Toxic (skull and crossbones)
Environmental Hazards: Potential water hazard, avoid transport with food, feed, or drinking water
Special Precautions: Secure packaging, compliant documentation, avoid temperature extremes
OSHA Status: Regulated as hazardous chemical
TSCA Status: For research and development only, not listed for commercial use
SARA Title III Sections 302/304/313: Not specifically listed
RCRA Status: Dispose of as hazardous waste due to toxicity
WHMIS (Canada): D1B – toxic material, D2B – sensitizing and irritant
European Regulations (REACH, CLP): Registered for scientific and medical use, restricts commercial and broad use
California Proposition 65: Not listed as carcinogen or reproductive toxin
Other National/Local Laws: Subject to special handling, storage, and transportation requirements per jurisdiction; consult applicable agencies for compliance
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