Material Safety Data Sheet: Noradrenalin bitartrate, l-

Identification

Product Name: Noradrenalin bitartrate, l-
Chemical Formula: C8H11NO3 • C4H6O6
CAS Number: 327-57-1
Synonyms: Norepinephrine bitartrate, L(-)-Noradrenaline bitartrate, Arterenol bitartrate
Recommended Use: Laboratory research, pharmaceutical ingredient
Contact Information of Supplier: Provided by manufacturer on label
Emergency Phone Number: Provided by local authorities or manufacturer

Hazard Identification

GHS Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritation, possible respiratory sensitizer
Label Elements: Hazard pictograms, signal words such as "Danger," hazard statements for acute toxicity and organ system hazards
Hazard Statements: Harmful if swallowed or inhaled, causes skin and eye irritation, may cause allergic respiratory reactions
Precautionary Statements: Avoid breathing dust, wash skin thoroughly after handling, use protective gear, store securely
Other Hazards: Potential cardiovascular effects upon significant exposure, risk to sensitive individuals with hypertension

Composition / Information on Ingredients

Substance: Noradrenalin bitartrate, l-
PURITY: >98% (by HPLC or supplier specification)
Other Components: Diluent or residual moisture as trace impurities, not intentionally added
Impurities: No relevant impurities known above regulated thresholds

First Aid Measures

Inhalation: Remove individual to fresh air immediately, supply artificial respiration if breathing stops, seek medical help
Skin Contact: Wash exposed skin with soap and water at once, remove contaminated clothing, consult medical personnel if irritation or systemic symptoms develop
Eye Contact: Flush eyes gently but thoroughly with water for at least 15 minutes, lift eyelids to ensure irrigation, obtain medical attention
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, seek medical evaluation promptly, potential for agitation, blood pressure changes, or systemic effects

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Fire Fighting Procedures: Wear full protective gear including self-contained breathing apparatus, avoid inhalation of combustion products
Unusual Fire/Explosion Hazards: Emits toxic fumes under fire conditions including oxides of nitrogen, carbon monoxide, carbon dioxide
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, tartrate breakdown products

Accidental Release Measures

Personal Precautions: Wear laboratory gloves, goggles, and dust mask, avoid skin and eye exposure, do not breathe dust
Environmental Precautions: Prevent entry into waterways, drains, soil
Spill Clean-Up: Sweep up without generating dust, place in a closed container for proper disposal, ventilate area after clean-up

Handling and Storage

Handling: Minimize dust generation, keep away from skin, eyes, and mucous membranes, always use within a chemical fume hood, wash hands after use
Storage: Store in tightly sealed containers, keep in a cool, dry, and well-ventilated space, protect from light and incompatible substances such as strong oxidizers, avoid moisture ingress
Special Storage Needs: Refrigerate if recommended by supplier, check for regulatory restrictions by country or facility

Exposure Controls and Personal Protection

Control Parameters: Occupational exposure limit values not established for this compound, minimize exposure by engineering controls
Engineering Controls: Use in a certified chemical fume hood, keep laboratory well ventilated
Personal Protective Equipment: Safety glasses or goggles, gloves (nitrile or similar laboratory type), lab coat, dust mask or NIOSH-approved respirator for large-scale operations
Respiratory Protection: In case of significant dust generation or spills, use appropriate respirator

Physical and Chemical Properties

Physical State: Solid
Appearance: White to off-white powder
Odor: Nearly odorless
pH: Slightly acidic in solution
Melting Point/Range: 258-264°C
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water, slightly soluble in ethanol
Partition Coefficient: Not readily available; compound is highly polar
Vapor Pressure: Negligible at room temperature
Flash Point: Not available; not flammable under typical conditions

Stability and Reactivity

Chemical Stability: Stable under normal handling and storage conditions
Incompatible Materials: Strong oxidizing agents, acids or bases with high reactivity
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Reactivity: No hazardous polymerization expected, sensitive to moisture and light
Conditions to Avoid: High temperature, direct sunlight, moisture

Toxicological Information

Acute Toxicity: Toxic by inhalation, ingestion, and in contact with skin; can cause marked changes in blood pressure, tachycardia, central nervous system agitation
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Symptoms of Exposure: Irritation of eyes and skin, dizziness, headache, palpitations, elevated blood pressure, anxiety, potential allergic reactions
Chronic Toxicity: Repeated exposure can affect cardiovascular and nervous systems; sensitization possible
Carcinogenicity: No available data indicates carcinogenic effects in humans
Reproductive Effects: No human data; lab data insufficient

Ecological Information

Ecotoxicity: No comprehensive testing reported; related compounds show aquatic toxicity at low concentrations
Mobility in Soil: Highly water soluble, expected to have significant mobility
Persistence and Degradability: Likely biodegradable, but breakdown products may persist
Bioaccumulation Potential: Low due to polarity and rapid degradation
Other Adverse Effects: May negatively affect aquatic organisms at high concentrations; caution advised to avoid environmental release

Disposal Considerations

Waste Disposal Methods: Dispose in accordance with local, regional, and national regulations, must not enter watercourses or sewage
Packaging Disposal: Ensure containers are empty and triple-rinsed before recycling or disposal
Special Precautions: Environmental hazard from improper disposal; incinerate in a chemical incinerator equipped with afterburner and scrubber if allowed

Transport Information

UN Number: Not typically assigned but verify with local regulations
UN Proper Shipping Name: Noradrenalin bitartrate, l-
Transport Hazard Class: Not classified as a hazardous material for transport under most regulations
Packing Group: Not applicable
Special Precautions for User: Secure packaging, transport in compliance with good laboratory practices, prevent inadvertent exposure or spillage

Regulatory Information

International Inventory Listings: Check local chemical inventory, may not be listed in all national inventories
EU Regulations: Not classified under CLP as a hazardous substance, but treated as a hazardous chemical for laboratory purposes
US Regulations: Not a controlled substance per DEA; follow OSHA, EPA guidelines for laboratory use
Other Regulatory Status: Observe all relevant regulations related to controlled laboratory chemicals; consult safety officer for institutional guidance