Product Name: (+)-Nicotine (+)-di-P-toluoyltartrate
Chemical Formula: C10H14N2 · 2(C9H8O3)
Synonyms: Nicotine ditoluoyltartrate, Nicotine, (+)-, with (+)-di-p-toluoyltartaric acid
Product Use: Laboratory research, chemical synthesis
Manufacturer: Supplier or local distributor contact details
Emergency Phone Number: Local poison control center, emergency fire/police/medical services
Recommended Restrictions: For professional, laboratory, or industrial use only
Hazard Classification: Acute toxicity (oral, dermal, inhalation), Skin irritation, Eye irritation, Respiratory hazard
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin, or inhaled. Causes skin and eye irritation. Harmful to the central nervous system.
Pictogram: Skull and crossbones, Exclamation mark
Precautionary Statements: Wash thoroughly after handling, Do not eat, drink, or smoke when using, Avoid breathing dust, fumes, gas, vapors, sprays, Wear protective gloves/protective clothing/eye protection/face protection, Remove contaminated clothing and wash before reuse
Potential Health Effects: Ingestion or inhalation can cause rapid onset of headaches, dizziness, nausea, respiratory distress, fatal at high doses
Environmental Hazard: Toxic to aquatic life with long lasting effects
Chemical Name: (+)-Nicotine (+)-di-P-toluoyltartrate
CAS Number: 54-11-5 (Nicotine component), 526-98-7 (di-p-toluoyltartaric acid)
Concentration: Typically over 95% purity by weight for laboratory-grade substance
Impurities and Stabilizing Additives: Trace impurities below reporting threshold, not considered to substantially contribute to hazard
Mixture: Combination of nicotine base and optically pure tartaric acid ester
Molecular Weight: Calculated based on composition—consult latest chemical database
Inhalation: Move exposed person to fresh air immediately, seek medical attention, keep person warm and quiet
Skin Contact: Remove contaminated clothing, wash skin with soap and water for at least 15 minutes, do not delay medical aid if symptoms develop
Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes while holding eyelids apart, remove contact lenses if present, seek immediate ophthalmic assistance
Ingestion: Do not induce vomiting, rinse mouth with water, obtain urgent medical advice
General Notes: Symptoms can occur rapidly, monitor breathing and pulse, seek emergency care at once. For unconscious person, do not give anything by mouth, place in recovery position
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray
Specific Hazards from Chemical: Emits toxic fumes under fire conditions—may release carbon monoxide, carbon dioxide, nitrogen oxides
Protective Equipment: Full protective clothing, self-contained breathing apparatus
Special Precautions: Avoid inhaling combustion products, keep containers cool with water spray, prevent runoff from fire control or dilution from entering drains, rivers, or lakes
Personal Precautions: Wear suitable protective clothing, gloves, eye/face protection, avoid inhalation or contact with skin
Environmental Precautions: Prevent further leakage or spillage if safe to do so, do not release into sewage or waterways
Cleanup Methods: Absorb with inert material (sand, diatomaceous earth), collect in appropriate, labeled chemical waste container, ventilate area, wash spill site after material pickup is complete
Decontamination: Dispose contaminated cleanup materials in sealed, approved waste containers as per local environmental regulations
Handling Practices: Use only in well-ventilated areas or fume hood, avoid all contact with skin, eyes, or clothing, avoid inhaling dust, wash hands after use
Storage Conditions: Store in tightly closed original container in a cool, dry, well-ventilated area away from incompatible substances, avoid sources of ignition, strong acids, oxidizing agents
Incompatibilities: Strong oxidizers, acids, bases—may react vigorously
Special Requirements: Store locked up, segregation from foodstuffs
Occupational Exposure Limits: ACGIH TLV 0.5 mg/m3 TWA (for nicotine), no established limit for compound as a salt
Engineering Controls: Local exhaust ventilation, chemical fume hood
Personal Protective Equipment: Approved respirator for organic vapor/particulate if risk of airborne exposure, chemical resistant gloves (nitrile or neoprene), splash-proof safety goggles, laboratory coat or apron
Hygiene Measures: Wash thoroughly after handling, remove and wash contaminated clothing separately before reuse, do not eat, drink, smoke, or use cosmetics in work area
Appearance: Colorless to pale yellow crystalline powder or solid
Odor: Characteristic tobacco-like, irritant odor
Odor Threshold: Not determined
pH: Not available (aqueous solution variable, acidic)
Melting Point/Range: 80–150°C (composition dependent)
Boiling Point: Decomposes before boiling
Flash Point: Not available
Evaporation Rate: Not determined
Flammability: May be combustible at high temperatures
Vapor Pressure: Not established for salt compound
Vapor Density: Not available
Solubility: Soluble in water, alcohols, but less volatile compared to nicotine base
Partition Coefficient (Log Kow): Not established
Autoignition Temperature: Not available
Decomposition Temperature: Above melting point with toxic fume release
Stability: Stable under recommended storage and handling conditions
Reactivity: Can react with strong oxidizing agents, acids, bases
Hazardous Reactions: May produce toxic gases under fire or thermal decomposition—nitrogen oxides, carbon monoxide
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, possible lower molecular weight organics
Conditions to Avoid: Heat, flames, sparks, moisture, contact with incompatible materials
Incompatibility: Strong acids, strong oxidizing agents
Routes of Exposure: Ingestion, inhalation, skin contact, eye contact
Acute Toxicity: Extremely toxic by all exposure routes; LD50 (oral, rat) nicotine base approx. 50 mg/kg. Toxic effects can occur at lower doses in humans
Chronic Toxicity: Prolonged or repeated exposure leads to systemic symptoms including tremors, convulsions, tachycardia, central nervous system stimulation, can cause addiction
Symptoms of Overexposure: Nausea, vomiting, drowsiness, headaches, confusion, hypertension, muscle weakness. In severe cases, seizures, respiratory paralysis, death
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA, but nicotine classified as hazardous and addictive
Reproductive Toxicity: Data suggest developmental and reproductive toxicity in high exposures
Environmental Fate: Very toxic to aquatic organisms, may cause long-term adverse effects in aquatic environment
Persistence and Degradability: Nicotine and its salts degrade under environmental conditions but remain hazardous until broken down
Bioaccumulation: Low to moderate potential for bioaccumulation, may biomagnify in aquatic environments
Mobility in Soil: Can leach to groundwater, especially in water-soluble salt form
Ecotoxicity: LC50 (fish, 96h): 4 mg/L (nicotine); EC50 (Daphnia, 48h): 0.24 mg/L
Other Effects: Harmful to plants and beneficial soil organisms
Waste Disposal Methods: Must follow all local, regional, and national hazardous waste management regulations
Disposal of Product: Collect waste in appropriate, labeled, sealed containers, incinerate in licensed chemical incinerator with afterburner and scrubber
Disposal of Contaminated Packaging: Containers should be triple rinsed, punctured, and disposed of or recycled according to official requirements
Precautions: Do not discharge to drains or environment, wear protective equipment during disposal
UN Number: UN1654 (Nicotine), similar precautions for salts
Proper Shipping Name: Nicotine compound, solid
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: I (high danger)
Marine Pollutant: Yes
Special Precautions for User: Ensure primary and secondary containers are sealed properly and labeled with hazardous material information
Regulatory Information: Subject to national and international control—consult all relevant shipping regulations (ADR, IMDG, IATA)
Label Requirements: Skull and crossbones, toxic and environmentally hazardous symbols
OSHA Status: Hazardous chemical according to OSHA Hazard Communication Standard
TSCA (USA): Listed
SARA (Title III, USA): Section 302: Not listed
State Regulations: Subject to chemical-specific reporting requirements
REACH (EU): Registration required for use above certain tonnage
Other Standards: Controlled under USEPA, EU CLP Regulation, International Chemical Safety Cards (ICSC)
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