Product Name: (+)-Nicotine Di-p-Toluoyl-D-Tartrate Salt
Chemical Formula: C27H30N2O8
CAS Number: 34646-07-2
Synonyms: (S)-Nicotine ditoluoyl-D-tartrate
Recommended Use: Research chemical, fine chemical applications
Manufacturer: [Insert details as per supply chain]
Contact Information: Supplier contact details for emergencies should always be posted on-site
Emergency Phone Number: Available local emergency and poison control services
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation) Category 2, Skin Sensitizer Category 1
Signal Word: Danger
Hazard Statements: Harmful if swallowed, toxic in contact with skin or if inhaled, may cause allergic skin reaction, may cause damage to organs through prolonged or repeated exposure
Pictograms: Skull and crossbones, exclamation mark, health hazard icon
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use personal protective equipment, do not eat, drink or smoke when using, keep away from food or feedstuffs, store locked up
Chemical Name: (+)-Nicotine Di-p-Toluoyl-D-Tartrate Salt
Percent: 98-100%
Impurities: Below 2% (may include trace solvents from synthesis)
Molecular Weight: 510.53 g/mol
Other Ingredients: No additional ingredients in standard preparations
Inhalation: Remove to fresh air, seek medical attention immediately, monitor respiratory distress, perform CPR if breathing stops
Skin Contact: Remove contaminated clothing, rinse skin with water for at least 15 minutes, seek medical advice, wash clothing before reuse
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, consult a physician
Ingestion: Do not induce vomiting, rinse mouth with water, never give anything by mouth to an unconscious person, seek emergency medical help
Most Important Symptoms: Nausea, difficulty breathing, muscular twitching, dizziness, headaches, convulsions, possible fatality at high doses
Advice for Physicians: Symptomatic and supportive treatment, monitor vital signs, consider administration of activated charcoal if ingestion was recent
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Extinguishing Media: Do not use water jets directly
Specific Hazards: Emits toxic fumes such as carbon oxides, nitrogen oxides, hydrogen chloride under fire conditions
Protective Equipment: Firefighters require full protective gear and self-contained breathing apparatus
Advice for Firefighters: Remove containers from danger zone if safe, contain run-off water, avoid inhaling toxic gases released during combustion
Personal Precautions: Wear suitable PPE including gloves, lab coats, eye protection, and respiratory protection if necessary
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid discharge into drains, surface and ground waters
Methods for Containment: Cover spills with inert absorbent (sand, earth, vermiculite), avoid generating dust, sweep up and place in suitable containers
Decontamination: Wash area with plenty of soapy water, ventilate the area, Dispose of all waste according to local regulations
Precautions for Safe Handling: Handle in a chemical fume hood, avoid contact with skin, eyes, and clothing, avoid inhalation of dust or vapors, use only with adequate ventilation, never eat/drink/smoke in work area
Storage Conditions: Store at 2–8°C (refrigerated), keep tightly closed in original container, protect from light, store in cool, dry, well-ventilated area, segregate from strong oxidizers, acids, and alkalis, keep away from food and animal feed
Occupational Exposure Limits: No specific OSHA or ACGIH limits established; treat as highly toxic
Engineering Controls: Ensure adequate ventilation, use local exhaust to capture vapors/dust
Personal Protective Equipment: Chemical safety goggles, gloves resistant to chemical penetration (nitrile recommended), long-sleeved lab coat or chemical suit, NIOSH approved respirator if exposure limits may be exceeded
Hygienic Measures: Wash hands thoroughly after handling, remove contaminated clothing and wash before reuse
Appearance: White to off-white crystalline powder
Odor: Distinct, tobacco-like odor
Odor Threshold: Data not available
pH: No data for water solution
Melting Point/Range: Approx. 210–225°C (decomposition possible)
Boiling Point/Range: Not applicable (decomposes before boiling)
Flash Point: Not determined
Evaporation Rate: Data not available
Flammability (Solid, Gas): No direct data; treat as potentially combustible
Upper/Lower Flammability or Explosive Limits: Not established
Vapor Pressure: Negligible at room temperature
Vapor Density: Data not available
Relative Density: No established data
Solubility: Soluble in water and organic solvents
Partition Coefficient (n-octanol/water): Data not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 200°C
Viscosity: Not applicable to solid material
Chemical Stability: Stable under recommended storage conditions, sensitive to high temperatures and strong oxidizers
Reactivity: No known hazardous reactions under normal conditions
Conditions to Avoid: Heat, open flame, exposure to strong acids or bases, oxidizing agents, high humidity
Incompatible Materials: Strong oxidizers (e.g., peroxides, nitric acid), acids, bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, toluene derivatives
Polymerization: No hazardous polymerization anticipated
Acute Toxicity: Very toxic by ingestion, skin contact and inhalation. LD50 (oral-rat): nicotine base approx. 50 mg/kg; toxicity enhanced by salt formation
Skin Corrosion/Irritation: May cause severe irritation, burns possible with prolonged contact
Serious Eye Damage/Irritation: Causes irritation, potential for serious injury on direct contact
Respiratory/Skin Sensitization: Sensitizer for susceptible individuals, allergic reactions possible
Germ cell Mutagenicity: No data available for this salt; nicotine shows mixed evidence in studies
Carcinogenicity: IARC: Not classifiable as to carcinogenicity, but nicotine suspected
Reproductive Toxicity: May affect fertility, teratogenic in animal models, risk to unborn child
STOT-Single Exposure: Potential for organ toxicity following acute exposure; symptoms include neurological disturbances, nausea, convulsions
STOT-Repeated Exposure: Chronic exposure can lead to systemic poisoning, liver and kidney damage, cardiovascular effects
Aspiration Hazard: Not established
Ecotoxicity: Very toxic to aquatic life with long-lasting effects; nicotine is hazardous to fish, daphnia, and aquatic invertebrates
Persistence and Degradability: Moderately persistent in soil and water, risk of bioaccumulation
Bioaccumulative Potential: Studies suggest bioaccumulation may occur in aquatic organisms
Mobility in Soil: Highly soluble in water, possible migration to groundwater
Other Adverse Effects: Even low concentrations may threaten non-target organisms such as pollinators, birds; avoid environmental release at all steps of use and disposal
Waste Treatment Methods: Waste must be handled as hazardous, incinerate in licensed chemical incinerators only, do not pour down drains or release into environment
Contaminated Packaging: Rinse with suitable solvent and dispose in accordance with local regulations, treat rinsates as hazardous
Special Precautions: Use registered professional waste contractors, documentation of disposal is mandatory for compliance
UN Number: 1654 (for nicotine compounds)
UN Proper Shipping Name: Nicotine compounds, solid, toxic
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Marine Pollutant: Yes
Environmental Hazards: Classified as hazardous for transportation over land, sea, and air
Special Precautions for User: Ensure all packaging is sealed, clearly labeled, protected from damage
Transport in Bulk: Not applicable
OSHA: Not specifically listed, but treat as highly toxic compound
SARA Title III: Not listed under Section 302, 304, or 313
TSCA Status: Components may be under reporting requirements
DSL/NDSL (Canada): Not listed
European Union (REACH): Pre-registration under evaluation
Hazard Symbols: T+ (Very toxic), N (Dangerous for environment)
Risk Phrases: R23/24/25 (Toxic by inhalation, in contact with skin and if swallowed), R50/53 (Very toxic to aquatic organisms, may cause long-term adverse effects)
Safety Phrases: S36/37/39 (Wear suitable protective clothing, gloves and eye/face protection), S45 (In case of accident or if you feel unwell seek medical advice immediately), S61 (Avoid release to the environment)
Other Regulatory Notes: Local, state, and federal authorities may impose additional requirements; refer to national regulations for full compliance
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