Product Name: (-)-Nicotine di-(+)-hydrogen tartrate
Synonyms: Nicotine hydrogen tartrate
CAS Number: 65-31-6
Recommended Use: Chemical research, laboratory use
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GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation) Category 2, Eye Irritation Category 2A, Skin Sensitizer Category 1
Pictograms: Skull and Crossbones, Exclamation Mark
Signal Word: Danger
Hazard Statements: Fatal if swallowed, toxic in contact with skin, causes serious eye irritation, may cause allergic skin reaction
Precautionary Statements: Do not breathe dust or vapor, avoid contact with skin and eyes, wear protective clothing, gloves and eye/face protection, wash hands thoroughly after handling
Potential Health Effects: Immediate effects can include nausea, vomiting, convulsions, respiratory failure; delayed effects may involve tremors, high blood pressure, arrhythmias
Chemical Name: (-)-Nicotine di-(+)-hydrogen tartrate
CAS Number: 65-31-6
EC Number: 200-603-3
Purity: Up to 98%
Other Components: Non-hazardous excipients not present
Impurities: Not expected to contain significant levels of impurities affecting classification
Inhalation: Move person to fresh air immediately, monitor for breathing difficulties, seek medical help; artificial respiration if breathing has stopped
Skin Contact: Remove contaminated clothing, rinse skin continuously with water for at least 15 minutes, immediate medical attention required
Eye Contact: Rinse eyes thoroughly with water for several minutes while lifting eyelids, remove contact lenses if present and easy to do, get medical attention
Ingestion: Do not induce vomiting, rinse mouth with water, give water to drink if conscious, get urgent medical attention; risk of fatal poisoning
Symptoms: Muscle twitching, high blood pressure, confusion, rapid heartbeat, respiratory distress
Note to Physician: Supportive treatment, monitor respiratory, cardiac function, atropine may be indicated for severe toxicity
Suitable Extinguishing Media: Dry chemical, CO2, foam, water spray for larger fires
Unsuitable Extinguishing Media: Direct water stream may spread product
Specific Hazards: Toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide, tartrate decomposition products
Protective Equipment for Firefighters: Self-contained breathing apparatus (SCBA), full protective gear
Advice for Firefighters: Combustible solid, hazardous vapors may accumulate in confined areas, use water spray to cool containers exposed to fire
Personal Precautions: Evacuate area, ventilate, prevent contact with skin and eyes, avoid inhaling dust
Protective Equipment: Chemical-resistant gloves, safety goggles, protective clothing, NIOSH-approved respirator
Methods for Cleanup: Sweep up without generating dust, collect in tightly sealed container for disposal, wipe surfaces with damp cloth, wash area thoroughly
Environmental Precautions: Prevent spillage from entering drains, ground, water systems; inform authorities if large spillage causes contamination
Handling: Only use in well-ventilated areas, avoid creation of dust, wear suitable protective gear, prevent contact with skin, eyes, and clothing, do not eat, drink, or smoke during handling
Storage: Store locked up in a cool, dry, well-ventilated place away from incompatible substances like oxidizers and acids, keep container tightly closed, protect from light and moisture
Incompatibilities: Strong oxidizers, acids, alkalis
Occupational Exposure Limits: No established limit for this compound, treat as highly toxic similar to nicotine (ACGIH TLV for nicotine: 0.5 mg/m3 TWA skin)
Engineering Controls: Laboratory fume hood, local exhaust ventilation
Personal Protective Equipment: Chemical-resistant gloves (nitrile), safety goggles, lab coat, approved respirator in absence of adequate ventilation
Hygiene Measures: Wash hands thoroughly after handling, remove and wash contaminated clothing before reuse
Appearance: White to off-white crystalline powder
Odor: Weak characteristic, may be faintly sweet
Odor Threshold: Not determined
pH: 2.1 – 2.8 (5% solution)
Melting Point: 90 – 95°C (decomposes)
Boiling Point: Not available (decomposes)
Flash Point: Non-flammable, not established
Evaporation Rate: Not applicable
Flammability: May emit toxic fumes when heated
Vapor Pressure: Not determined
Solubility: Very soluble in water, slightly soluble in ethanol
Partition Coefficient (log Kow): Not available
Decomposition Temperature: >90°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Exposure to heat, light, moisture, air
Incompatible Materials: Strong oxidizers, bases, acids
Hazardous Decomposition Products: Possible release of nitrogen oxides, carbon monoxide, carbon dioxide, tartrate vapors
Reactivity: No dangerous reactivity expected under normal use
Acute Toxicity: Oral LD50 (rat): 50 – 60 mg/kg (nicotine salt basis)
Routes of Exposure: Inhalation, ingestion, dermal contact
Symptoms: Nausea, vomiting, headache, confusion, convulsions, tachycardia, extreme toxicity can be fatal
Chronic Effects: Repeated exposure may damage nervous system, heart, liver; risk of addiction exists
Skin Sensitization: Known to cause allergic reactions in sensitive individuals
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, OSHA
Mutagenicity: Nicotine-related compounds have tested positive in some assays
Reproductive Effects: Evidence of reproductive harm induced by nicotine
Target Organs: Central nervous system, cardiovascular system
Ecotoxicity: Highly toxic to aquatic life, both acute and chronic, even at low concentrations
Persistence and Degradability: Biodegradable, but rapid breakdown in soil and water limited by toxicity to microbes
Bioaccumulative Potential: Potential for bioaccumulation in aquatic organisms
Mobility in Soil: May leach into soil; solubility in water increases mobility
Other Adverse Effects: Avoid introduction into environment, particularly bodies of water
Waste Disposal Methods: Dispose as hazardous waste in accordance with local, regional, and national regulations; do not dump in drains or water courses; incineration in permitted facility preferred
Contaminated Packaging: Dispose of containers as hazardous waste, empty thoroughly before disposal
Special Procedures: Consult with licensed chemical waste disposal service
UN Number: 1654 (Nicotine, solid)
Proper Shipping Name: Nicotine compound, solid
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: I (high danger)
Marine Pollutant: Yes
Special Precautions: Use secondary containment if possible, make sure labels and documentation comply with transport regulations
Environmentally Hazardous Substance: Mark as marine pollutant if shipped internationally
TSCA Status: Listed
DSL/NDSL: Listed
EU Regulations: Classified as hazardous under CLP; subject to REACH restrictions
US Federal Regulations: SARA 302/304 Extremely Hazardous, SARA 313 required reporting
Workplace Regulations: OSHA Hazard Communication Standard applies
Other State Regulations: California Proposition 65 listed for developmental toxicity due to nicotine
Label Elements: Proper pictograms and hazard warnings required under GHS
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