Product Name: Metoprolol Tartrate
Chemical Name: 1-(Isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol L-(+)-tartrate
Synonyms: Lopressor, Betaloc
Recommended Use: Pharmaceutical ingredient (antihypertensive, beta-blocker)
Supplier Information: [Pharmaceutical company contact details]
Emergency Phone Number: [Emergency contact information]
CAS Number: 56392-17-7
Classification: Not classified as hazardous according to OSHA Hazard Communication Standard (29 CFR 1910.1200)
GHS Label Elements: No signal word, hazard pictograms, or precautionary statements required
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Pictograms: None
Target Organs: Heart, central nervous system
Pictogram Description: Not required based on available data
Hazard Statements: May cause mild irritation to skin, eyes, and mucous membranes; possible cardiovascular effects if ingested in large amounts
Precautionary Statements: Avoid contact with eyes, skin, and clothing; do not ingest; use adequate ventilation
Chemical Name: Metoprolol Tartrate
Component: Metoprolol Tartrate
Concentration: 98-100% w/w (pure active pharmaceutical ingredient)
CAS Number: 56392-17-7
Impurities: Minimal; no significant hazardous impurities present
Inhalation: Move person to fresh air, keep at rest; seek medical attention if symptoms develop
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing; get medical advice if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do; seek medical assistance if irritation continues
Ingestion: Rinse mouth thoroughly with water; do not induce vomiting; seek immediate medical attention, especially if large dose is suspected
Symptoms and Effects, Acute and Delayed: Possible decrease in heart rate or blood pressure, dizziness, possible respiratory distress; may cause mild irritation to mucous membranes
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: No restrictions known
Specific Hazards During Fire: Combustion may produce carbon oxides, nitrogen oxides, and other toxic fumes
Protective Equipment for Fire-Fighters: Self-contained breathing apparatus and full protective clothing
Advice for Firefighters: Move containers from fire area if it can be done without risk; avoid inhalation of combustion products
Flash Point: Not available
Explosion Data/Sensitivity: No data available; not expected to present explosion risk
Personal Precautions: Avoid dust formation; avoid breathing dust; use personal protective equipment as required
Protective Equipment: Nitrile gloves, safety glasses, lab coat, dust mask or respirator
Environmental Precautions: Do not allow large quantities to enter drains, surface water or soil
Methods for Cleaning Up: Collect spilled material by carefully sweeping or using an industrial vacuum (HEPA filtered if available); transfer to a labeled waste container for proper disposal; flush residues with plenty of water
Reference to Other Sections: Refer to Section on Personal Protection and Disposal Considerations
Precautions for Safe Handling: Handle in a well-ventilated area; avoid contact with skin, eyes, and clothing; avoid inhalation of dust or particles; wash hands thoroughly after handling
Conditions for Safe Storage: Store in tightly closed original container; keep in a cool, dry, well-ventilated area; protect from light and moisture; keep away from incompatible materials such as strong oxidizers
Storage Temperature: Recommended storage between 15°C and 30°C
Incompatible Materials: Strong acids, bases, and oxidizing agents
Control Parameters: No occupational exposure limits established for Metoprolol Tartrate
Engineering Controls: Use with local exhaust ventilation or other engineering controls to minimize airborne exposure
Personal Protection: Safety glasses with side shields or goggles, nitrile or latex gloves, lab coat, respiratory protection if dust becomes significant
Hygiene Measures: Wash hands before breaks, after handling, and after use; do not eat, drink, or smoke in work area
Environmental Exposure Controls: Prevent release into the environment
Appearance: White to off-white crystalline powder
Odor: Odorless or faint odor
Odor Threshold: Not determined
pH: 4.5–5.5 (solution)
Melting Point/Freezing Point: 120–123°C
Boiling Point/Range: Not determined (decomposes)
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Upper/Lower Flammability or Explosive Limits: Not determined
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: Not available
Solubility: Freely soluble in water; slightly soluble in ethanol, methanol, chloroform
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: Decomposes before boiling
Molecular Weight: 684.81 g/mol
Chemical Stability: Stable under recommended storage and handling conditions
Possibility of Hazardous Reactions: No dangerous reactions expected under normal conditions
Conditions to Avoid: Excessive heat, moisture, direct sunlight
Incompatible Materials: Strong oxidizers, strong acids and bases
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, unidentified toxic compounds during combustion or thermal decomposition
Information on Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): ~350 mg/kg; data may vary with different sources; can cause bradycardia, hypotension, drowsiness, respiratory depression in overdose
Skin Corrosion/Irritation: May cause mild irritation
Serious Eye Damage/Irritation: May cause mild to moderate temporary irritation
Respiratory or Skin Sensitization: No known sensitizing effects
Germ Cell Mutagenicity: Not classified as mutagenic based on available data
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: No evidence of reproductive toxicity at occupational exposures
STOT-Single Exposure: Not expected to cause organ toxicity from single exposure at typical contact
STOT-Repeated Exposure: No evidence of significant risk with occupational exposures
Aspiration Hazard: Not expected to pose aspiration hazard
Symptoms: In therapeutic overdose, may see bradycardia, hypotension, confusion, bronchospasm, gastrointestinal upset
Toxicity: Information specific to environmental toxicity is limited; generally not expected to present significant hazard to aquatic organisms at typical environmental concentrations
Persistence and Degradability: Expected to be biodegradable, but persistence may occur in soil and water at low concentrations
Bioaccumulative Potential: Low bioaccumulation potential
Mobility in Soil: Mobile in water; can migrate through soil into groundwater
Other Adverse Effects: No data available from large-scale studies; prudent practice is to avoid uncontrolled releases
Waste Treatment Methods: Dispose of in accordance with federal, state and local environmental regulations
Disposal of Product: Treat as pharmaceutical waste; incineration is preferred if permitted
Disposal of Contaminated Packaging: Packaging may contain product residues; dispose as unused product
Other Disposal Recommendations: Do not discharge into drains or the environment; consult licensed waste disposal contractor
UN Number: Not regulated
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not regulated for transport by road, air, or sea
Packing Group: Not regulated
Environmental Hazards: Not classified as a marine pollutant
Special Precautions for User: Avoid dust generation and uncontrolled spills during transport
Transport in Bulk: Not applicable
US Regulations: Not listed as hazardous under OSHA, SARA, CERCLA, or RCRA; not a controlled substance
TSCA Inventory: Not listed
California Prop 65: Not listed
Canada (DSL/NDSL): Not listed on DSL/NDSL
EU Regulations: Not classified under EU Regulation (EC) No 1272/2008
Country-Specific Information: Handle according to national, state, and local laws; pharmaceutical use strictly regulated
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