Product Name: Metaraminol Hydrogen (+)-Tartrate
Synonyms: Aramine tartrate; Metaraminol bitartrate
CAS Number: 33402-03-8
Use: Vasopressor agent in clinical emergency settings, blood pressure support, chemical research
Supplier: Listed by certified pharmaceutical and chemical entities
Contact Information: Emergency phone and supplier’s contact listed according to local regulatory requirements
Classification: Acute toxicity (oral), Specific organ toxicity (single exposure), Eye irritation
GHS Signal Word: Warning
Hazard Statements: Harmful if swallowed, may cause eye and skin irritation, potential cardiovascular effects through systemic absorption
Precautionary Statements: Avoid skin contact, wear appropriate protective equipment, use under well-ventilated conditions, wash hands thoroughly after handling
NFPA Rating: Health 2, Flammability 0, Reactivity 0
Chemical Name: Metaraminol Hydrogen (+)-Tartrate
Purity: ≥98%
Molecular Formula: C9H13NO2•C4H6O6
Molecular Weight: 315.3 g/mol
Impurities: Trace levels below harmful thresholds for clinical laboratory use
Other Information: Substance exists as a white to off-white crystalline powder; odorless
Inhalation: Remove person to fresh air, seek medical advice for persistent symptoms such as headache, rapid heartbeat, or respiratory issues
Skin Contact: Rinse affected area with soap and water, remove contaminated clothing immediately, consult medical professional if irritation occurs
Eye Contact: Flush eyes with water for several minutes, hold eyelids open, seek medical attention without delay
Ingestion: Rinse mouth, do not induce vomiting, call poison control or seek emergency medical care, provide information from MSDS
Most Important Symptoms: Nausea, hypertension, cardiac arrhythmia, dizziness, localized skin or eye irritation
Suitable Extinguishing Media: Dry chemical, CO₂, water spray, or foam
Specific Hazards: Product does not ignite easily; hazardous decomposition may release carbon oxides, nitrogen oxides
Protective Equipment: Firefighters to wear self-contained breathing apparatus and protective clothing
Procedures: Use equipment that does not stir up dust, avoid inhalation of smoke
Other Information: Prevent runoff from fire control from entering drains or water supplies
Personal Precautions: Restrict access to area, use proper protective equipment including gloves, lab coat, and goggles, avoid generating dust
Environmental Precautions: Stop spillage from reaching waterways, sewers, soil
Cleanup Methods: Sweep up dry powder, place in suitable closed containers for disposal, ventilate the area thoroughly, wash contaminated surfaces with mild detergent and water
Disposal: Handle according to local hazardous waste regulations
Handling: Avoid handling without personal protective equipment, prevent formation of dust, do not eat or drink near the substance
Storage Temperature: Store at 2–8°C (refrigerated) in a tightly sealed container
Protection Against Fire and Explosion: Keep away from sources of ignition; use antistatic measures
Incompatible Materials: Strong oxidizers, acids
Other Precautions: Label containers clearly, restrict access to trained personnel
Exposure Limits: No occupational exposure limits established, minimize exposure to lowest practicable levels
Engineering Controls: Work in fume hood or with effective local exhaust ventilation
Personal Protective Equipment: Nitrile gloves, protective lab clothing, approved safety goggles or glasses
Hygiene Measures: Wash hands after handling, avoid direct skin contact
Monitoring: Implement regular inspection and cleaning routines for workspaces
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: 3.0–5.0 (1% solution in water)
Melting Point: Around 193–196°C
Boiling Point: Data not available; decomposes before boiling
Solubility: Freely soluble in water, low solubility in organic solvents
Partition Coefficient (log Kow): No available data
Vapor Pressure: Not applicable
Flash Point: Not applicable
Explosive Properties: No explosive properties detected
Other Data: Stable appearance under normal laboratory conditions
Chemical Stability: Remains stable under tightly controlled, normal conditions
Reactivity: Non-reactive with common packaging materials
Hazardous Reactions: None under standard handling, avoid mixing with strong acids or oxidizers
Decomposition Products: Carbon oxides, nitrogen oxides on combustion
Conditions to Avoid: Excess moisture, high temperatures, sources of ignition
Acute Toxicity: Harmful if swallowed, causes negative cardiovascular effects in humans
Routes of Entry: Inhalation, ingestion, skin and eye contact
Symptoms of Exposure: Elevated blood pressure, headache, palpitations, nervousness, potential temporary blurred vision, possible local irritation
Chronic Effects: Potential risk from repeated overexposure not well documented; regular safety monitoring recommended
Carcinogenicity: No data indicating carcinogenic, mutagenic, or reproductive risks
Other Data: Risk management needed for individuals with pre-existing cardiovascular disorders
Aquatic Toxicity: Not much data for acute or chronic effects on aquatic species, chemicals like this moved through hospital or laboratory wastewater may show localized environmental persistence
Mobility in Soil: Information not fully established
Persistence and Degradability: Substance may not degrade easily; avoid uncontrolled release
Bioaccumulative Potential: Low expected based on structure and water solubility
Other Adverse Effects: Adverse long-term environmental impact considered low if responsible disposal followed
Methods of Disposal: Place in sealed, clearly labeled containers for transfer to licensed hazardous waste disposal facility, incineration preferred practice where regulations permit
Environmental Precautions: Do not dispose into drains, waterways, or soil
Contaminated Packaging: Handle as hazardous waste, arrange effective cleaning or replacement of containers
UN Number: Not classified as dangerous for transport by air, sea, or land
Transport Hazard Class: Not applicable
Packing Group: Not regulated for transport
Special Precautions: Ship according to standard procedures for pharmaceutical chemicals, ensure containers are secure, accompanied by proper documentation and safety information
Environmental Hazards: Not considered a marine pollutant
Labelling: Requires hazard and precautionary labels aligning with GHS, OSHA, or equivalent standards
Inventory Status: Listed in most major chemical regulatory inventories such as TSCA, REACH, AICS, DSL
Chemical Safety Assessment: Assessment available through suppliers
Restrictions: Use limited to trained laboratory and healthcare professionals
Other Information: Regular review and updates based on new toxicity or incident data
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