Material Safety Data Sheet for Metaraminol Bitartrate

1. Identification

Product Name: Metaraminol Bitartrate
Chemical Name: 2-(3-hydroxyphenyl)-2-hydroxyethylamine bitartrate
Synonyms: Aramine, Metaradrine Bitartrate
Manufacturer: [Enter Manufacturer Information]
Recommended Uses: Laboratory reagent, pharmaceutical intermediate
CAS Number: 56-52-4
Emergency Contact Number: [Insert Emergency Contact]

2. Hazard Identification

GHS Classification: Acute Toxicity (Oral, Inhalation), Serious Eye Irritation, Skin Irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes skin irritation; Causes serious eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust; Wash hands after handling; Wear protective gloves, clothing, and eye protection
Potential Health Effects: Ingestion may lead to cardiovascular effects, nausea, vomiting; Skin exposure may cause redness; Eye contact may cause pain and redness

3. Composition / Information on Ingredients

Chemical Identity: Metaraminol Bitartrate
CAS Number: 56-52-4
Concentration: 97–100%
Impurities: Trace organic impurities, not expected to affect hazard classification

4. First Aid Measures

Eye Contact: Rinse eyes gently with clean water for up to 20 minutes; Remove contact lenses if present; Seek medical advice if discomfort persists
Skin Contact: Wash area with mild soap and water; Remove contaminated clothing; Seek medical advice if irritation continues
Inhalation: Move to fresh air; Keep individual comfortable and warm; Get medical help if breathing is labored
Ingestion: Rinse mouth with clean water; Do not induce vomiting; Seek immediate medical assistance

5. Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam for small fires
Hazards Arising from Chemical: Emits toxic fumes of nitrogen oxides and carbon monoxide on combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Firefighting Procedures: Approach fire from upwind, cool containers with water spray to prevent rupture

6. Accidental Release Measures

Personal Protection: Wear chemical-resistant gloves, safety goggles, and dust mask
Spill Response: Use non-sparking tools to collect material; Sweep gently or use absorbent for larger spills; Avoid raising dust
Environmental Precautions: Prevent entry into drains, soil, and waterways; Isolate contaminated area
Cleanup Methods: Place waste in sealed containers for disposal following local regulations

7. Handling and Storage

Handling: Work in well-ventilated areas; Avoid dust generation; Avoid skin and eye contact
Storage: Store in original tightly sealed container in cool, dry area; Keep away from heat, sparks, and incompatible chemicals
Incompatibilities: Strong oxidizing agents
Specific Requirements: Keep container closed when not in use; Label container clearly

8. Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust ventilation or fume hood
Personal Protective Equipment: Chemical splash goggles, gloves resistant to chemicals, lab coat
Respiratory Protection: Suitable dust mask or respirator when airborne dust forms
Hygiene Measures: Wash hands and forearms after handling; Remove contaminated clothing promptly

9. Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 146–149°C
Solubility: Freely soluble in water; Slightly soluble in alcohol
pH Value: Neutral to slightly acidic aqueous solution
Density: Not measured; expected between 1.2–1.3 g/cm³
Stability: Stable at normal temperature and pressure
Decomposition: May release carbon oxides and other toxic gases on thermal decomposition

10. Stability and Reactivity

Chemical Stability: Stable under normal storage and use conditions
Reactivity: Low reactivity at room temperature
Conditions to Avoid: Strong heat, exposure to sunlight, contact with open flame
Incompatible Materials: Oxidizers, acids, strong bases
Hazardous Decomposition: Carbon monoxide, carbon dioxide, and nitrogen oxides on combustion

11. Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin, eye contact
Acute Oral Toxicity (LD50): Rat approx. 690 mg/kg
Acute Inhalation Toxicity: Not established; avoid exposure
Skin Corrosion/Irritation: Causes irritation on prolonged or repeated exposure
Eye Damage/Irritation: Causes irritation and possible corneal damage
Chronic Effects: Cardiovascular symptoms possible with repeated exposure
Other Data: Not classified as carcinogen, mutagen, or reproductive toxin

12. Ecological Information

Ecotoxicity: Expected to pose minimal hazard to aquatic organisms at low concentrations; High concentrations may produce adverse effects
Persistence and Degradability: Possibly biodegradable; exact rate not established
Bioaccumulation Potential: Bioaccumulation unlikely based on structure
Mobility in Soil: Expected to be mobile in aqueous environments; potential for leaching at large spills
Other Adverse Effects: Avoid larger releases into surface water; no data on ozone depletion or photochemical ozone creation

13. Disposal Considerations

Waste Disposal: Collect and keep in sealed, properly labeled containers; Dispose of via licensed chemical waste contractor
Unused Product: Do not dispose in household garbage or drains
Contaminated Packaging: Rinse thoroughly before discarding or recycling per local requirements
Local Regulations: Follow national, regional, and local disposal regulations

14. Transport Information

UN Number: Not regulated as a dangerous good for transport
Proper Shipping Name: Not regulated
Hazard Class: Not assigned
Packing Group: Not assigned
Special Precautions: Secure containers during transport to prevent spillage
Environmental Hazards: Not classified as hazardous for transportation purposes

15. Regulatory Information

Labeling Compliance: Hazard Communication Standard (29 CFR 1910.1200, OSHA), REACH, CLP
Inventory Listings: Listed on appropriate chemical inventories where required
Workplace Exposure Limits: OSHA, ACGIH limits not established
Regulatory Status: Subject to workplace hazard communication rules; Not classified as a controlled drug under federal schedules
Other Info: Operators must observe workplace safety and environmental responsibilities relevant to their region