Product Name: Manganese D-Gluconate
Other Names: Manganese(II) gluconate, Gluconic acid, manganese(2+) salt
Synonyms: Manganous gluconate, E12
CAS Number: 6485-39-8
Recommended Use: Mineral supplement, food fortification, laboratory chemical
Supplier: Manufacturer or distributor contact details on label or accompanying documentation
Emergency Contact: Local emergency response provider
GHS Classification: Eye irritation, category 2A; Specific target organ toxicity (single exposure), category 3
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, May cause respiratory irritation if dust is inhaled
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, Wash thoroughly after handling, Use only outdoors or in well-ventilated area, Wear eye protection, Seek medical attention if symptoms develop
Routes of Exposure: Inhalation, Skin contact, Eye contact, Ingestion
Health Hazards: Irritation to respiratory system, Possible mild skin sensitivity in rare cases, Strong irritant to eyes
Chemical: Manganese D-Gluconate
Formula: C12H22MnO14
Molecular Weight: 445.25 g/mol
Concentration: 100% (pure substance, as supplied for supplement/ingredient use)
Ingredient: Manganese(II) Gluconate
Impurities/Other Components: Trace water, possible minor organic acids (less than 0.1%)
Origin: Vegan/Vegetarian (no animal-derived feedstocks used in the synthesis)
Eye Contact: Rinse immediately with plenty of water for several minutes; hold eyelids open; remove contact lenses if present and easy; continue rinsing for at least 15 minutes; seek medical attention if irritation persists
Skin Contact: Wash skin thoroughly with soap and water; remove contaminated clothing and seek medical advice if signs of irritation develop
Inhalation: Remove person to fresh air; provide oxygen if breathing is difficult; obtain medical attention if symptoms continue
Ingestion: Rinse mouth with water; drink two glasses of water if the person is conscious; do not induce vomiting; seek medical assistance if feeling unwell
Notes to Physician: Treat symptomatically; there is no known specific antidote
Suitable Extinguishing Media: Dry chemical, CO2, water spray, foam
Specific Hazards: Dust can form explosive mixtures with air if concentrations are high, Product decomposes at high temperatures to release oxides of carbon and manganese which may be hazardous
Protective Equipment: Self-contained breathing apparatus and full protective clothing recommended for firefighters
Special Methods: Move containers from fire area if possible, Use water mist to cool nearby containers, Avoid direct water stream on burning chemical to prevent spread of dust clouds
Combustion Products: Carbon monoxide, Carbon dioxide, Manganese oxides, Irritating fumes
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid inhalation of dust, wear suitable protective equipment including gloves, safety glasses, and dust respirator
Environmental Precautions: Prevent spill from entering drains, soils, sewers, and waterways; notify relevant authorities if contaminated watercourses
Methods for Clean-up: Sweep up or vacuum spilled product carefully to avoid dust generation, place in proper waste containers for disposal, wipe area with damp disposable towels to remove residues
Other Recommendations: Use non-sparking tools, avoid creating aerosols or dust clouds during cleanup, wash hands after handling spills
Handling: Avoid creating dust, use only in well-ventilated locations, wear protective clothing such as gloves and goggles, keep containers tightly closed, practice good industrial hygiene
Storage: Store in tightly sealed containers in a dry, cool, well-ventilated area; Keep away from incompatible materials (strong acids, strong oxidizers); Protect from moisture and sunlight; Store away from sources of ignition or heat
Safe Practices: Use grounded and bonded containers, follow local and national safety regulations, limit access to storage areas to trained personnel
Exposure Limits: OSHA PEL: 5 mg/m³ (as Mn), ACGIH TLV: 0.1 mg/m³ (as Mn, inhalable fraction)
Engineering Controls: Use local exhaust ventilation, general ventilation, or fume hoods to minimize airborne dust
Respiratory Protection: Use approved dust mask or respirator (e.g., N95 or equivalent) if dust levels exceed occupational exposure limits or ventilation not adequate
Skin Protection: Wear chemical-resistant gloves (nitrile, PVC), lab coats or aprons where needed
Eye Protection: Use safety goggles or face shields to protect from dust contact
Hygiene Measures: Wash hands and exposed skin before eating or drinking, do not eat, drink, or smoke during use, wash contaminated clothing before reuse
Appearance: Fine crystalline powder
Color: Light pink to pale beige
Odor: Odorless
Odor Threshold: Not applicable
pH (1% solution): 6.5 - 7.5
Melting Point/Freezing Point: Decomposes above 200°C (392°F), does not have true melting point
Boiling Point: Not applicable
Flash Point: Not flammable
Evaporation Rate: Not relevant
Flammability: Will not ignite under normal conditions; dust clouds may be combustible in high concentrations
Vapor Pressure: Negligible at room temperature
Relative Density: 1.8 - 2.0 g/cm3
Solubility: Soluble in water, insoluble in most organic solvents
Partition Coefficient: Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: >200°C (releases manganese oxides)
Viscosity: Not applicable
Chemical Stability: Stable under normal ambient and anticipated storage and handling conditions
Reactivity: Non-reactive in dry, cool, and clean environments
Conditions to Avoid: High heat, moisture, strong acids, strong oxidizers, direct sunlight
Incompatible Materials: Acids (releases toxic gases), oxidizers (increases fire hazard), strong bases (possible decomposition)
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, manganese oxides, fumes
Polymerization: Will not occur
Acute toxicity: Low acute oral and dermal toxicity
LD50 (rat oral): >5,000 mg/kg
Skin Corrosion/Irritation: Mild irritation possible for sensitive individuals
Serious Eye Damage/Irritation: Causes irritation, redness, and pain
Respiratory or Skin Sensitization: Inhalation of dust may cause coughing or respiratory discomfort
Chronic Effects: Prolonged inhalation of high concentrations of dust may cause manganese neurological symptoms (much less likely than with manganese oxides)
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Mutagenicity: No data showing mutagenic potential
Reproductive Toxicity: Not expected at dietary use levels
Other Information: At recommended supplement or ingredient levels, manganese gluconate is not anticipated to result in adverse health effects for healthy adults; individuals with pre-existing manganese metabolism disorders should avoid excessive intake
Ecotoxicity: Not classified as hazardous to aquatic environment at typical use concentrations; high levels may be harmful to aquatic organisms due to manganese ion toxicity
Mobility in Soil: High solubility in water means potential for local dispersion
Persistence and Degradability: Gluconate component is biodegradable; manganese ions do not degrade
Bioaccumulation Potential: Manganese is a trace element and essential micronutrient for plants and animals, unlikely to bioaccumulate significantly at normal exposure
Aquatic Toxicity: LC50 (fish, 96h): >100 mg/L (as manganese ion); EC50 (daphnia, 48h): >100 mg/L
Other Effects: Avoid release to the environment at concentrations above recommended agricultural or dietary levels
Waste Disposal Methods: Collect and place material in properly labeled containers for recycling, recovery, or disposal according to local regulations; do not dispose of in household garbage or untreated municipal wastewater
Contaminated Packaging: Clean containers with water before re-use or dispose as hazardous waste
Special Instructions: Consult local waste authority and comply with all relevant environmental and hazardous waste regulations
Avoid: Disposal into drains or natural water bodies, direct release of dust to atmosphere
UN Number: Not regulated
Proper Shipping Name: Manganese D-Gluconate
Transport Hazard Class: Not classified as hazardous
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions: Protect containers from physical damage and moisture during transport; ensure secure closure to prevent loss of material
Transport Labels: None required for road, rail, air, or sea
Inventory Status: Listed on U.S. TSCA, EU REACH, Canada DSL, Australia AICS
Safety Regulations: OSHA (29 CFR 1910.1200), EU CLP, Canadian WHMIS; not listed as a controlled substance
Food Additive Approval: Approved for use as a mineral supplement in food and feed in many countries; refer to local regulatory standards
Labeling Requirements: Safety labeling in line with GHS/EU CLP if supplied as chemical
Other Legal Requirements: Follow workplace health and safety guidance, use and ingredient declarations as per FDA, EFSA, or other regional agencies where relevant
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