Product Name: Lorcaserin-L-tartrate
Chemical Name: 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine L-tartrate
Synonyms: Lorcaserin tartrate
CAS Number: 856681-05-5
Formula: C11H14ClN•C4H6O6
Recommended Use: Research, pharmaceuticals
Supplier Details: Contact the supplying laboratory or manufacturer for emergency numbers and further information
Emergency Overview: White to off-white crystalline powder, can cause mild to moderate irritation if inhaled, ingested, or comes in contact with skin or eyes
GHS Classification: Acute toxicity (oral, category 4), eye irritation (category 2A)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause respiratory tract irritation
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use only in a well-ventilated area, wear protective gloves, clothing, and eye protection
Potential Health Effects: Inhalation or ingestion can cause nausea, dizziness, respiratory discomfort, and possible effects on the central nervous system
Chemical Name: Lorcaserin-L-tartrate
Concentration: ≥ 98%
CAS Number: 856681-05-5
Impurities: Less than 2%, identity varies based on supplier
Other Components: No hazardous ingredients noted in usual handling concentrations
Inhalation: Move person to fresh air, seek medical attention if symptoms persist or breathing becomes difficult
Skin Contact: Wash immediately with soap and plenty of water, remove contaminated clothing
Eye Contact: Rinse thoroughly with water for at least 15 minutes, lift eyelids occasionally during rinsing; get medical attention if discomfort continues
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by a medical professional, seek immediate medical attention
Symptoms: May include respiratory irritation, headache, dizziness, eye redness
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Extinguishing Media: Do not use high-pressure water streams directly on chemical
Fire Hazards: Product dust and vapors may form explosive mixture with air if dispersed
Hazardous Combustion Products: May produce carbon monoxide, carbon dioxide, hydrogen chloride, nitrogen oxides on burning
Special Protective Equipment: Wear full protective clothing, self-contained breathing apparatus, chemical-resistant shoes and gloves
Advice for Firefighters: Use caution, avoid inhaling combustion gases, contain run-off water to prevent chemical spread
Personal Precautions: Evacuate non-essential personnel, use proper PPE including gloves, lab coat, safety goggles, and NIOSH-approved respirator
Environmental Precautions: Prevent entry into drains or water supplies, alert authorities if chemical enters the environment
Containment Procedures: Cover spill with inert absorbent (sand, vermiculite), scoop into suitable container
Cleaning Methods: Clean spill site with soap and water after material pick-up, ventilate area
Disposal: Dispose contaminated materials in accordance with local, state, and national regulations
Handling: Use in chemical fume hood, avoid creating dust, use spark-proof equipment, avoid direct contact with skin and eyes
Hygiene: Wash hands thoroughly after handling, do not eat, drink, or smoke during use
Storage: Store in tightly closed original container at 2-8°C, keep away from heat sources, sunlight, oxidizing agents, and moisture
Special Precautions: Protect from static discharge, maintain good ventilation, segregate from incompatible materials
Exposure Limit Values: No specific OSHA, NIOSH, or ACGIH limits established
Engineering Controls: Local exhaust ventilation, eyewash stations, emergency showers recommended in working area
Personal Protection: Nitrile gloves, lab coat or apron, safety glasses or goggles, dust mask or NIOSH-approved respirator under dust-producing conditions
Environmental Exposure Controls: Procedures required to avoid contamination of environment, frequent cleaning of working surfaces
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable (solid)
Melting Point: 198–204°C (decomposition possible)
Solubility: Soluble in water, ethanol, methanol
Boiling Point: Not available
Flash Point: Not available
Vapor Pressure: Not applicable
Density: Approx. 1.4 g/cm³
Partition Coefficient (log P): Not determined
Other Data: Stable under recommended storage conditions, may discolor on prolonged air exposure
Chemical Stability: Stable under prescribed storage and handling
Reactivity: Inert under normal laboratory conditions
Conditions to Avoid: Excess heat, direct sunlight, mechanical shock, moisture
Incompatible Materials: Strong oxidizers, strong acids and alkalis
Hazardous Decomposition Products: CO, CO₂, NOx, HCl may form under fire conditions
Polymerization: No hazardous polymerization expected
Acute Toxicity (oral): LD50 (rat): Approx. 250–400 mg/kg (data based on structurally similar substances)
Skin Irritation: May cause mild irritation, especially with prolonged or repeated contact
Eye Contact: Causes irritation, redness, watering
Respiratory Effects: May cause coughing, respiratory discomfort if dust inhaled
Chronic Exposure: No robust data, chronic exposure not recommended, animal tests suggest possible neuro-hormonal effects under massive dosing
Carcinogenicity: Not listed by IARC, NTP, OSHA as carcinogen
Mutagenicity: No mutagenic effects found in Ames test with lorcaserin
Sensitization: No data indicating strong sensitizing potential
Aquatic Toxicity: Limited data; predicted to be harmful to aquatic organisms with long lasting effects
Persistence and Degradability: Expected to be moderately persistent in environment, combination with tartrate salt may influence breakdown rates
Bioaccumulation: Not expected to bioaccumulate significantly
Mobility in Soil: Likely to be moderately mobile due to water solubility
Other Adverse Effects: Minimize release to the environment; avoid uncontrolled discharge into sewage or water bodies
Waste Disposal Methods: Place in tightly sealed, labeled chemical waste container, send to registered hazardous waste facility
Containment: Avoid dust formation, never dispose through municipal drains
Contaminated Packaging: Triple-rinse containers, render unusable, dispose as hazardous solid waste
Environmental Precautions: Prevent waste from entering surface or ground water systems
Regulatory Disposal Guidance: Comply with local, state, and federal guidelines for pharmaceutical and hazardous waste
UN Number: Not allocated for this compound
Proper Shipping Name: No established DOT shipping name; recommended: “Non-regulated pharmaceutical intermediate”
Transport Hazard Class: Not classified as dangerous for transportation under ADR, RID, IMDG, IATA
Packing Group: Not applicable
Environmental Hazards: Not classified as marine pollutant, but spill precautions should be observed
Special Transport Precautions: Ship in original, tightly closed packaging, protect from rough handling
US Federal Regulations: Not listed as controlled substance; not subject to TSCA inventory listing
OSHA Status: Considered hazardous; follow laboratory chemical safety requirements
SARA Title III: No SARA Section 302, 304, or 313 reporting required
EU Regulations: Not listed in Annex XVII of REACH; no harmonized classification
Other International Regulations: Refer to national legislation for import, handling, and disposal rules; in some regions, subject to pharmaceutical control acts
Label Elements: Product labeling must indicate hazards and handling care per local standards
Inventory Status: May be regulated as a precursor or research chemical in certain countries
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