Product Name: Lorcaserin Hemi-L-Tartrate
Synonyms: Lorcaserin Tartrate, Lorcaserin Tartrate Salt
Chemical Formula: C11H15Cl2N·C4H6O6
Intended Use: Research and pharmaceutical manufacturing
Manufacturer: Confidential supplier details available on request
Emergency Contact: Local poison control center or emergency medical services
CAS Number: 856681-05-5
Recommended Restrictions: For laboratory, academic, or regulated drug development purposes only
GHS Classification: Acute toxicity (oral, category 4), Eye irritation (category 2A)
GHS Label Elements: Warning symbol, exclamation mark
Hazard Statements: Harmful if swallowed, causes serious eye irritation
Precautionary Statements: Avoid contact with eyes, skin, and clothing, Do not eat, drink, or smoke during use, Wash hands after handling
Potential Health Effects: Inhalation of dust can irritate respiratory tract, skin contact can induce redness or itch, eye exposure produces stinging and watering, ingestion may cause nausea, dizziness, or more serious toxicity in significant doses
Note on Chronic Exposure: Long-term effects not fully studied; animal studies highlight possible neuroendocrine impacts
Chemical Identity: Lorcaserin Hemi-L-Tartrate
Component 1: Lorcaserin base, 53.4%
Component 2: L-Tartaric Acid, 46.6%
Impurities: Less than 1%, manufacturing trace residues
Physical State: Off-white crystalline powder
Purity: Not less than 98% by HPLC
Formulation: As supplied, no excipients or binders included
Eye Contact: Rinse immediately with copious amounts of cool water for at least 15 minutes, hold eyelids apart, consult physician promptly
Skin Contact: Remove contaminated clothing, wash exposed area with soap and plenty of water, seek medical attention if irritation persists
Inhalation: Move victim to fresh air, support breathing with oxygen if necessary, obtain medical attention for coughing, shortness of breath, or symptoms of poisoning
Ingestion: Rinse mouth, do not induce vomiting unless directed by professional, seek immediate medical advice, present MSDS at medical facilty
Most Important Symptoms: Eye burning, respiratory discomfort, gastrointestinal upset, central nervous system depression at high exposures
Special Notes for Medical Providers: Treat supportively and monitor for possible serotonin syndrome, seizures, or arrhythmia
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, water spray, or alcohol-resistant foam
Unsuitable Media: Direct water jet may scatter powdered material
Hazardous Combustion Products: Hydrogen chloride, oxides of carbon, nitrogen oxides, possibly phosgene and chlorinated tars
Protective Equipment: Chemical resistant suit, self-contained breathing apparatus
Fire Fighting Advice: Apply water from a distance to keep surrounding containers cool, prevent run-off from reaching drains or sewers
Personal Precautions: Don chemical splash goggles, nitrile gloves, laboratory coat, use a certified dust mask, ventilate enclosed areas
Environmental Precautions: Prevent spillage from entering waterways, soil, or storm drains
Methods for Clean Up: Collect spillage using HEPA-filter equipped vacuum or scoop up mechanically, transfer contents to labeled chemical waste drum, wipe area with damp absorbent
Emergency Procedures: Evacuate unprotected personnel from spill vicinity, restrict access until thorough cleaning achieved, avoid raising dust
Safe Handling Practices: Handle using local exhaust ventilation or fume hood, minimize dust generation, avoid direct contact with skin or eyes
Conditions for Safe Storage: Store in tightly sealed original container, cool, dry, and well-ventilated area away from direct light, incompatible materials (strong oxidizers, acids)
Packaging Requirements: Use secondary containment, clearly labeled; access restricted to authorized staff
Special Handling Advice: Regularly inspect storage area for sign of leaks or degradation, record movement in chemical inventory
Occupational Exposure Limits: No official OSHA or ACGIH limit; internal occupational exposure bands recommended based on pharmaceutical activity, usually <10 µg/m3 for active handling
Engineering Controls: Biological safety cabinet or chemical fume hood, dust extraction, room-side warning signage
Personal Protective Equipment: Impermeable gloves, chemical splash goggles, disposable laboratory coat, certified P100 respirator for open handling above threshold
Hygiene Measures: Wash hands before breaks, after finishing work, ban food and drinks in active areas, change contaminated clothing promptly
Environmental Monitoring: Routine surface wipe testing, air sampling as required by institutional safety protocols
Appearance: Fine, off-white to light beige crystalline powder
Odor: No significant odor
Molecular Weight: 409.3 g/mol
Melting Point: 199 – 201°C
Solubility: Freely soluble in water, slightly soluble in methanol, practically insoluble in nonpolar solvents
pH (1% solution): Approximately 4.0
Boiling Point: Decomposes before boiling
Vapor Pressure: Not expected to generate significant vapor under ambient conditions
Partition Coefficient: LogP 2.6 (as base), low mobility in environment
Flash Point: Not flammable under standard conditions
Chemical Stability: Stable under room temperature and recommended conditions
Reactivity: Limited, may react with strong oxidizing agents, acids, and bases
Possible Hazardous Reactions: No hazardous polymerization anticipated
Conditions to Avoid: High humidity, direct sunlight, high heat
Incompatible Materials: Powerful oxidizers, strong acids or bases
Hazardous Decomposition Products: HCl fumes, carbon monoxide, carbon dioxide under fire or high-temperature conditions
Likely Routes of Exposure: Ingestion, inhalation, skin or eye contact
Acute Toxicity: LD50 (oral): rat 720 mg/kg (approximate); LD50 (dermal): not established
Skin Corrosion/Irritation: May cause mild redness or pruritus
Serious Eye Damage/Irritation: Irritant, may cause sustained inflammation
Respiratory Sensitization: Not expected, but inhalation of high-concentration dust may cause pulmonary symptoms
Carcinogenicity/Mutagenicity: No IARC, NTP, or OSHA listing; animal data predict low risk but include some reproductive and developmental findings
Other Information: Repeated high-dose exposure in animal studies documented CNS effects and altered feeding behaviors
Eco-Toxicity: Harmful to aquatic life with long lasting effects, low LC50 for algae and invertebrates predicted (<1 mg/L)
Persistence and Biodegradability: Moderately persistent, slow degradation in aquatic and terrestrial environments
Bioaccumulation Potential: LogP value suggests limited potential for build-up in food chain
Mobility in Soil: Molecule has limited mobility given water solubility and charge at neutral pH
Other Adverse Effects: No known interaction with ozone layer or photochemical smog, indirect toxicity to mammals/birds not established
Waste Handling: Treat as pharmaceutical hazardous waste, segregate from general lab trash
Container Disposal: Empty container retains drug residue, triple rinse and treat as hazardous waste
Methods for Disposal: Send all material and contaminated disposables to controlled incineration facility authorized for pharmaceutical chemicals
Special Instructions: Avoid discharge in drain, sewer, or natural water body
Regulatory Waste Codes: Consult local, state, and federal guidelines for current hazardous pharmaceutical waste definitions
UN Number: Not assigned specific UN number as of current transport tables
Transport Hazard Class: Considered non-regulated under most global shipping rules unless shipped in bulk
Proper Shipping Name: Lorcaserin Hemi-L-Tartrate, solid, non-hazardous for air, sea, and land
Packing Group: Not applicable
Special Precautions: Outer packaging must prevent powder escape, protect from moisture and mechanical stress, check airway/courier guidelines before shipment
TSCA Status: Not listed for commercial import in the United States
EU REACH Status: Substance not registered for commercial manufacture or sale
DEA Control: Lorcaserin classified as Schedule IV controlled substance in the U.S.
Labeling Requirements: Comply with GHS for workplace labeling, Schedule IV for possession and transfer
Additional Regulations: Subject to local, state, and federal pharmaceutical control and reporting mandates, detailed tracking and documentation may be necessary for all transactions
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