Product Name: Levarterenol Bitartrate
Chemical Name: (R)-2-Amino-1-(3,4-dihydroxyphenyl)ethanol bitartrate
Common Synonyms: Norepinephrine bitartrate, Noradrenaline bitartrate
CAS Number: 65-31-6
Recommended Use: Pharmaceutical active ingredient, vasopressor in medical emergencies
Supplier Details: Contact details should include company name, address, and emergency phone number
Emergency Contact: Local and national poison control hotlines
GHS Classification: Acute toxicity (Oral, Category 4), Eye irritation (Category 2A), Skin irritation (Category 2)
Hazard Statements: Harmful if swallowed, may cause eye and skin irritation
Signal Word: Warning
Pictograms: Exclamation Mark
Precautionary Statements: Avoid inhalation, do not ingest, prevent contact with skin and eyes
Known Health Effects: Rapid heartbeat, hypertension, potential eye damage, allergic skin reactions
Target Organs: Cardiovascular system, nervous system, eyes, skin
Environmental Impact: Could affect aquatic organisms if released into water sources
Chemical Identity: Levarterenol bitartrate
Synonyms: Norepinephrine bitartrate
CAS Number: 65-31-6
Purity: >99%
Impurities: Minimal, typically pharmaceutical-grade trace by-products
Molecular Formula: C8H11NO3·C4H6O6
Molecular Weight: 337.29 g/mol
General Note: Seek professional medical attention for exposure
If Inhaled: Move person to fresh air, assist breathing if needed
If Swallowed: Rinse mouth thoroughly, do not induce vomiting
Skin Contact: Remove contaminated clothing, wash area with soap and water
Eye Contact: Rinse with water for at least 15 minutes, seek medical help promptly
Rescue Measures: Keep affected person calm and warm, ensure open airway if breathing is irregular
Suitable Extinguishing Media: Use water mist, CO2, dry chemical, or foam
Unsuitable Media: High pressure water jets may spread spilled substance
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Firefighting Gear: Wear full protective clothing and self-contained breathing apparatus
Additional Advice: Cool exposed containers with water, prevent runoff from entering waterways
Personal Precautions: Evacuate unnecessary personnel, ventilate area well
Protective Equipment: Use gloves, goggles, laboratory coat, and respirator if dust forms
Containment: Prevent product from entering drains or waterways
Cleanup: Sweep or vacuum up without creating dust, place in sealed containers for disposal
Decontamination: Wash spill site after material pickup
Disposal: Use approved waste disposal site, follow local regulatory guidelines
Handling Precautions: Employ engineering controls to minimize dust exposure, handle in well-ventilated area
Protection: Wear fitting protective equipment, avoid direct contact with skin and eyes
Storage: Store in tightly sealed container, keep away from light, moisture, and incompatible substances
Temperature: Room temperature or as specified by manufacturer for stability
Incompatibles: Strong oxidizing agents, strong acids, bases
Specific Use: For professional and laboratory use only; follow standard protocols
Engineering Controls: Work within fume hood or ventilated enclosure
Exposure Limits: No established occupational exposure limits; handle with caution
Personal Protection: Use gloves (nitrile or latex), lab coat, safety glasses, respiratory protection if airborne dust forms
Hygiene Measures: Wash hands thoroughly after use, keep work clothing separate from regular laundry
Environmental Controls: Prevent release to environment, use containment measures for waste
Appearance: White to off-white crystalline powder
Odor: Faint or none
pH (1% solution): Approximately 3-5
Melting Point: 222–224°C (decomposes)
Solubility: Freely soluble in water, slightly soluble in ethanol
Boiling Point: Not available, decomposes before boiling
Vapor Pressure: Negligible
Density: Not established, but typically dense as a solid
Partition Coefficient: Log P less than zero (hydrophilic)
Chemical Stability: Stable under recommended storage conditions
Sensitivity: Sensitive to light and air; may degrade forming quinones or other oxidized products
Reactivity: Reacts vigorously with strong oxidizers
Hazardous Decomposition: Produces toxic fumes of CO, CO2, and nitrogen oxides during decomposition
Polymerization: Does not polymerize under normal conditions
Incompatibles: Strong acids, strong bases, oxidizing agents
Routes of Exposure: Ingestion, skin absorption, inhalation, eye contact
Acute Toxicity: Oral LD50 (rat): 100-200 mg/kg (estimate, literature-based)
Skin Corrosion/Irritation: May cause redness or irritation
Eye Damage/Irritation: Potential for eye irritation from dust or solution
Carcinogenicity: No data; not listed as carcinogen by IARC, NTP, OSHA
Mutagenicity: No direct evidence of mutagenic potential
Symptoms of Overexposure: Agitation, rapid heartbeat, hypertension, headache, anxiety, sweating
Chronic Exposure: Prolonged exposure can cause effects on central nervous system and cardiovascular system
Ecotoxicity: Product may show toxicity to aquatic life in significant concentrations
Bioaccumulation Potential: Expected to have low bioaccumulation
Persistence/Degradability: Rapidly degrades in environment, but breakdown products may persist for short periods
Mobility in Soil: High water solubility, mobile in soil and surface water
Other Adverse Effects: Possible impact on invertebrates, disrupts natural aquatic processes
Waste Disposal: Collect and transfer into a clearly labeled, sealed waste container
Method: Incinerate or use chemical destruction as per local waste regulations
Container Disposal: Rinse empty containers, render unusable, dispose of as hazardous waste
Prohibited Disposal: Do not flush into sewer, surface water, or groundwater
Legal Compliance: Adhere strictly to local, regional, and national regulations regarding pharmaceutical waste
UN Number: Not specifically assigned
UN Shipping Name: Not regulated for transport in small quantities, may be classified as hazardous on bulk or in concentrated form
Transport Hazard Class: None under standard IATA or DOT classifications
Packing Group: Not applicable
Labels Required: Not designated
Special Precautions: Protect from moisture, sunlight, and extreme temperatures in transit
US Regulations: TSCA inventory: Not listed, prescription medication
EU Regulations: REACH registration exemption as medicinal product
International Inventories: Not classified as hazardous under GHS for most uses
Workplace Regulations: OSHA hazard communication may require site-specific labeling and training
Other Standards: Controlled under prescription-only regulations, handled only by qualified personnel
Labelling Requirements: Safety information and hazard warnings must be clearly visible for medical and laboratory settings
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