Material Safety Data Sheet for Leucomycin Tartrate

Identification

Product Name: Leucomycin Tartrate
Synonyms: Kitasamycin Tartrate
Chemical Family: Macrolide antibiotic
CAS Number: 1675-53-2
Formula: C42H67NO14·C4H6O6
Intended Use: Research, pharmaceutical manufacturing
Manufacturer: [Supplier information supplied directly with product]
Emergency Contact: [Emergency phone, direct from supplier]

Hazard Identification

GHS Classification: Acute Toxicity (Oral), Skin Sensitization, Specific Target Organ Toxicity
Signal Word: Warning
Hazard Statements: May cause allergic skin reactions. Harmful if swallowed. Causes damage to organs through repeated exposure.
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust. Wear suitable protective clothing. Avoid contact with skin and eyes. Wash hands after handling.

Composition / Information on Ingredients

Chemical Name: Leucomycin Tartrate
Concentration: 100% (unless otherwise diluted)
Impurities: Trace residual solvents, byproducts from synthesis (manufacturer-specific)
Other Components: None identified above reportable levels

First Aid Measures

Inhalation: Move person to fresh air. If symptoms develop, seek medical help.
Skin Contact: Remove contaminated clothing. Wash affected area with plenty of water and mild soap. Seek medical attention for skin reactions or irritation.
Eye Contact: Rinse cautiously with water for at least fifteen minutes, keeping eyelids open. Remove contact lenses if present and easy. Contact physician.
Ingestion: Rinse mouth thoroughly. Seek medical advice and show this sheet to medical personnel. Do not give anything by mouth if person is unconscious.

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical powder, carbon dioxide
Specific Hazards: Emits toxic fumes under fire conditions (such as carbon monoxide, carbon dioxide, nitrogen oxides)
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Other Recommendations: Move containers from fire area if possible. Avoid inhaling combustion byproducts.

Accidental Release Measures

Personal Precautions: Use appropriate personal protective equipment (gloves, goggles, lab coat, particulate respirator if dust is generated). Avoid contact with spilled material.
Spill Cleanup Methods: Sweep up carefully, avoiding dust generation. Place in a suitable, sealed container for disposal.
Environmental Precautions: Prevent entry into drains, sewers, or waterways. Notify authorities if large quantities enter environment.
Decontamination: Clean spilled area with detergent and water after removal.

Handling and Storage

Safe Handling: Handle in a well-ventilated area, away from incompatible substances. Wear personal protective clothing and avoid skin or eye contact.
Storage: Store in original container, tightly closed, in a cool, dry, and well-ventilated location away from direct sunlight and moisture.
Storage Temperature: 2–8°C for long-term or as indicated by supplier.
Other Instructions: Avoid exposing container to physical damage or extreme temperatures.

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust or general room ventilation to limit airborne dust.
Respiratory Protection: Use an approved particulate respirator if airborne concentrations are likely.
Eye Protection: Safety goggles or face shield
Skin Protection: Wear chemical-resistant gloves and lab coat.
Other Protective Equipment: Emergency eyewash stations and showers should be accessible.

Physical and Chemical Properties

Appearance: White to off-white powder
Odor: Odorless or faint characteristic smell
Odor Threshold: Not available
pH: Not available
Melting Point: Decomposes before melting
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water, partially soluble in organic solvents
Vapor Pressure: Not applicable
Density: Not determined
Other Characteristics: Stable under recommended conditions, sensitive to strong oxidizers

Stability and Reactivity

Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Not reactive under expected use and storage
Possibility of Hazardous Reactions: No dangerous reactions known under normal conditions
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, toxic fumes on combustion or decomposition

Toxicological Information

Likely Routes of Exposure: Inhalation, skin, eyes, ingestion
Acute Toxicity: Harmful if swallowed (oral LD50 not fully characterized, may cause nausea, vomiting, or diarrhea)
Chronic Effects: Risk of organ effects from repeated exposures, possible allergic reactions including dermatitis and respiratory sensitization
Symptoms of Exposure: Skin irritation, eye irritation, respiratory discomfort, allergic reactions
Carcinogenicity: No data indicating classification as carcinogenic by IARC, NTP, OSHA
Other Risk Information: May cause antibiotic-resistant effects if mishandled or misused

Ecological Information

Aquatic Toxicity: Toxic to aquatic organisms, may cause long-term effects in aquatic environments
Persistence and Degradability: Expected to be slowly biodegradable in the environment
Bioaccumulation Potential: Low to moderate, based on macrolide structure
Mobility in Soil: May leach in moist soil conditions
Other Ecological Data: Avoid uncontrolled release. Collect for proper disposal, prevent contamination of surface and ground waters.

Disposal Considerations

Waste Disposal Methods: Dispose of in accordance with national and local regulations for pharmaceutical chemicals.
Packaging Disposal: Triple rinse empty containers and offer for recycling or disposal in line with legal requirements.
Do Not: Dump into drains, water courses, or onto the ground.
Other Disposal Guidance: Contact licensed waste contractor for larger quantities or for advice related to waste solutions and contaminated packaging.

Transport Information

UN Number: Not regulated as dangerous goods for transport (check latest guidance and supply-specific instructions)
UN Shipping Name: Non-hazardous pharmaceutical substance
Hazard Class: Not classified
Packing Group: Not applicable
Transport Labels: None required
Special Precautions: Protect from physical damage; ensure container integrity during transport.

Regulatory Information

TSCA Status: Not listed for commercial distribution in the United States
European Regulations: EC Inventory: Listed as pharmaceutical substance, take note of REACH status
SARA Title III: Not subject to reporting
Other National Regulations: Follow country-specific rules for antibiotics and hazardous substances
Safety Evaluation: Handle using precautions outlined in this sheet and keep safety data current with updates from supplier or regulatory sources.