Substance Name: L(+)-Threo-2-Amino-1-phenyl-1,3-propanediol
Synonyms: Threo-β-Amino-α-phenyl-1,3-propanediol
CAS Number: 51-81-0
Recommended Use: Intermediate for pharmaceuticals, research applications
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GHS Classification: Harmful if swallowed, causes serious eye irritation, may cause respiratory irritation
Signal Word: Warning
Hazard Statements: H302: Harmful if swallowed; H319: Causes serious eye irritation; H335: May cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: P261: Avoid breathing dust; P264: Wash thoroughly after handling; P270: Do not eat, drink or smoke during use; P280: Wear protective gloves, clothing, eye and face protection
Potential Health Effects: Skin: May cause mild irritation. Eye: Risk of severe irritation, pain, redness. Inhalation: Irritation of mucous membranes and respiratory tract. Ingestion: May cause gastrointestinal discomfort, nausea
Environmental Hazards: Product could be dangerous to aquatic organisms if released in large quantities
Chemical Name: L(+)-Threo-2-Amino-1-phenyl-1,3-propanediol
CAS No: 51-81-0
EC No: 200-141-9
Purity: 98% or greater
Impurities: Trace organic and inorganic contaminants, typically less than 2% combined
Inhalation: Move the person to fresh air. If they have trouble breathing, medical attention is necessary. Maintain open airways and provide oxygen if trained and available
Skin Contact: Remove contaminated clothing immediately. Wash skin thoroughly with plenty of soap and water. Do not use solvents or diluents
Eye Contact: Rinse eyes cautiously with water for several minutes. Remove contact lenses if present and easy to do, continue rinsing. Medical attention if symptoms persist
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel. Drink water only if conscious. Get medical attention promptly
Most Important Symptoms: Irritation to eyes, nose, throat; nausea if ingested
Advice for Doctors: Symptomatic and supportive treatment
Suitable Extinguishing Media: Water spray, foam, carbon dioxide, dry chemical
Unsuitable Media: Strong direct water jets may scatter the material
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, toxic fumes
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective gear
Special Hazards: Dust can form explosive mixtures in air in rare cases, avoid accumulation
Personal Precautions: Ensure adequate ventilation. Avoid inhaling dust, avoid contact with skin, eyes, clothing. Use personal protective equipment
Environmental Precautions: Do not allow large amounts to enter drains, surface, or groundwater
Spill Cleanup Methods: Sweep up and place in a suitable, sealable waste container. Avoid generating dust. Wash area with plenty of water after cleanup, ventilate
Safe Handling: Always handle in well-ventilated areas. Avoid raising dust. Prevent direct contact with skin, eyes, clothing. No eating, drinking, or smoking near work. Wash hands after use
Storage Conditions: Store in tightly closed original container, in a dry, cool, and well-ventilated place. Keep away from incompatible substances, direct sunlight, and sources of ignition
Incompatibles: Strong oxidizers, strong acids and bases
Control Parameters: No established occupational exposure limits; handle as nuisance dust (10 mg/m³ total dust recommended)
Engineering Controls: Use local exhaust ventilation or fume hood. Eye wash facilities and safety showers at the work area
Personal Protective Equipment:
Gloves: Nitrile, neoprene, PVC recommended
Eye Protection: Safety goggles, face shield if heavy exposure
Clothing: Lab coat, long sleeves, full-length pants
Respiratory Protection: Dust mask or respirator (NIOSH approved) if dust formation likely
Hygiene Measures: Keep work clothes separate from other clothing, remove and wash after use
Appearance: White to off-white crystalline solid
Odor: Odorless or very faint sweet smell
Odor Threshold: Not determined
pH: No data for solid, solution expected to be neutral to slightly basic
Melting Point: 170-173°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable (high melting/boiling point)
Flammability: Non-flammable under normal conditions
Explosive Limits: Product not known to be explosive
Vapor Pressure: Not relevant, negligible at room temperature
Solubility: Soluble in water, some organic solvents
Density: 1.2–1.3 g/cm³
Viscosity: Not applicable (solid)
Partition Coefficient (Log Kow): Not established
Autoignition Temperature: No data
Decomposition Temperature: >175°C
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No hazardous reactions expected under normal conditions
Possibility of Hazardous Reactions: Reacts with strong oxidizing agents, can decompose with heat
Conditions to Avoid: High temperatures, prolonged exposure to light and air, generation of dust
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Acute Toxicity: Estimated LD50 (oral, rat) >500 mg/kg; ingestion leads to gastrointestinal disturbances
Skin Corrosion/Irritation: May cause mild, temporary irritation
Eye Damage/Irritation: Causes irritation, potential for corneal injury if significant exposure
Respiratory Sensitization: Dust may irritate mucous membranes
Skin Sensitization: Not a known sensitizer based on available data
Germ Cell Mutagenicity: No relevant data found
Carcinogenicity: Not classified as carcinogenic
Reproductive Toxicity: No sufficient data
Repeated Dose Toxicity: Chronic exposure might cause effects similar to acute exposure, prolonged inhalation to dust not recommended
Potential Symptoms: Headache, dizziness, coughing if dust inhaled; abdominal pain, nausea by ingestion
Ecotoxicity: No specific studies, expected low toxicity to aquatic life in small quantities, but avoid large spills into environment
Persistence and Degradability: Readily biodegradable by microbial action
Bioaccumulative Potential: Not expected to bioaccumulate
Mobility in Soil: Fairly mobile in water, soluble product can move through soil and reach groundwater if released in quantity
Other Adverse Effects: Aquatic toxicity not significant at typical use levels; promote responsible disposal
Waste Treatment Methods: Collect waste in properly labeled containers. Chemical waste management per local, regional, national, and international rules
Recommended Disposal: Incineration preferred for bulk materials, small amounts can be diluted and flushed with plenty of water if allowed by regulations
Contaminated Packaging: Dispose of as unused product
Precautions: Don’t release undiluted product to environment. Consult with authorities before disposal
UN Number: Not classified as dangerous for transport
Proper Shipping Name: Not regulated
Transport Hazard Class: None
Packing Group: None
Environmental Hazards: Not environmentally hazardous under transport classification
Special Precautions: Prevent spillage during loading/unloading, keep container sealed and upright
SARA 313: Not listed
TSCA: Listed
REACH: Exempt or registered for low volume
DSL/NDSL (Canada): Listed
WHMIS Classification: Non-controlled
California Proposition 65: Not listed
Other Regulations: Product complies with OSHA Hazard Communication Standard, not subject to special labeling unless mixed or modified
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