Material Safety Data Sheet: l-Noradrenaline d-bitartrate

Identification

Product Name: l-Noradrenaline d-bitartrate
Chemical Name: (R)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol hydrogen (2R,3R)-2,3-dihydroxybutanedioate
Chemical Formula: C8H11NO3 · C4H6O6
CAS Number: 108341-18-0
Usage: Laboratory reagent, pharmaceutical applications
Supplier Information: Refer to purchasing documentation
Emergency Contact: Local poison control center, occupational health provider

Hazard Identification

GHS Classification: Acute Toxicity (Oral) Category 4, Acute Toxicity (Dermal) Category 4, Serious Eye Irritation Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, harmful in contact with skin
Pictogram(s): Exclamation mark
Potential Health Effects: Rapid heartbeat, headache, hypertension, nausea, irritation to eyes and skin
Precautionary Statements: Avoid contact with skin and eyes, wash hands thoroughly after handling, do not eat or drink during use, use protective gear

Composition / Information on Ingredients

Component: l-Noradrenaline d-bitartrate
Synonyms: Noradrenalinum, Levarterenol tartrate
Content: ≥98% by weight
Impurities: Trace levels of related catecholamines, residual solvents
Physical State: Crystalline powder
Color: Off-white to light beige

First Aid Measures

Eye Contact: Flush immediately with plenty of water for at least 15 minutes, lift eyelids to ensure thorough rinsing, seek medical assistance if irritation persists
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, contact physician if irritation occurs
Ingestion: Do not induce vomiting, rinse mouth with water, give small amount of water to drink only if conscious, seek urgent medical attention
Inhalation: Move to fresh air, support breathing with oxygen if needed, seek medical advice for prolonged symptoms
Note to Physician: Treat symptomatically, monitor cardiovascular system closely

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: High-pressure water jets
Special Hazards: May emit toxic fumes of nitrogen oxides, carbon monoxide, and carbon dioxide upon combustion
Protective Equipment: Wear self-contained breathing apparatus and fully protective clothing
Firefighting Instructions: Remain upwind, avoid inhalation of combustion products, cool exposed containers with water spray

Accidental Release Measures

Personal Precautions: Use personal protective equipment including gloves, safety goggles, and lab coat, prevent skin and eye contact
Environmental Precautions: Prevent spill from entering drains or water systems
Methods for Containment and Cleaning Up: Scoop up spilled material, avoid creating dust, place in suitable container for disposal, ventilate area, wash spill site after cleanup

Handling and Storage

Handling: Minimize dust generation, avoid breathing dust or vapors, handle in fume hood if available, use dedicated work clothing
Storage: Keep container tightly closed in a dry, cool, and well-ventilated area, protect from light and moisture, store away from strong oxidizers and acids
Special Considerations: Use only in accordance with relevant regulations and guidelines, ensure containers are labeled properly

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established for this substance
Engineering Controls: Use local exhaust ventilation, chemical fume hood
Personal Protective Equipment: Safety glasses or face shield, protective gloves (nitrile or latex), lab coat or apron, suitable respirator if ventilation is insufficient
Hygiene Measures: Wash hands and exposed areas after handling, do not eat, drink, or smoke in laboratory

Physical and Chemical Properties

Appearance: Off-white to light beige crystalline powder
Odor: Odorless or faint chemical scent
pH (solution): 3.0–5.0
Melting Point: 218–225°C (decomposition)
Solubility: Freely soluble in water, sparingly soluble in ethanol
Molecular Weight: 337.26 g/mol
Partition Coefficient: Data not available
Vapor Pressure: Not applicable
Boiling Point: Not applicable (decomposes on heating)

Stability and Reactivity

Stability: Stable under recommended storage conditions, sensitive to air, light, and moisture
Conditions to Avoid: Exposure to heat, light, moisture, incompatibles
Incompatible Materials: Strong acids, bases, oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Polymerization: Will not occur under normal conditions

Toxicological Information

Routes of Exposure: Ingestion, inhalation, skin, and eye contact
Acute Toxicity: LD50 (oral, rat) estimated 50–500 mg/kg, can cause systemic effects such as hypertension, arrhythmia, and restlessness
Chronic Effects: No reliable long-term data available; possible risk to cardiovascular health upon repeated exposure
Sensitization: No data confirming allergic response
Symptoms of Exposure: Agitation, nausea, elevated blood pressure, headache, rapid pulse, local irritation

Ecological Information

Ecotoxicity: Limited acute aquatic toxicity data; catecholamines may affect aquatic organisms at low concentrations
Persistence and Degradability: Degrades slowly in the environment due to aromatic structure
Bioaccumulation: Low potential for bioaccumulation
Mobility in Soil: May migrate in moist environments
Other Adverse Effects: Avoid release to the environment; large quantities may disrupt aquatic biology

Disposal Considerations

Disposal Methods: Dispose of material in accordance with local, regional, and national regulations
Handling of Waste: Collect in clearly marked, sealed containers, store for pick-up by licensed chemical waste disposal service
Contaminated Packaging: Rinse containers with water, dispose of rinsate as hazardous chemical waste
Prohibited Practice: Do not allow to reach sewage system, landfill, or natural water sources

Transport Information

UN Number: Not classified as dangerous goods under current transport guidelines
Proper Shipping Name: Not regulated
Transport Hazard Class: Not assigned
Packing Group: Not designated
Special Precautions: Protect from moisture, keep in sealed packaging, avoid mixing with incompatible substances during transport
Labeling: Ensure outer packaging carries clear identification and hazard notification where required

Regulatory Information

Inventory Listings: May be listed under various national chemical inventories
Labelling Requirement: Follows Globally Harmonized System (GHS) for chemical classification
Workplace Controls: Employers must provide appropriate safety training and PPE to users
Other Laws: Subject to transport, handling, and disposal regulations aimed at chemical safety and environmental protection
REACH Compliance: Registration may be required for commercial production or use in the European Union
Other Notes: Users should refer to applicable local, national, and international laws before use or disposal