Product Name: L-Noradrenaline bitartrate
Chemical Name: (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol, hydrogen tartrate
Synonyms: (−)-Norepinephrine bitartrate, Levarterenol bitartrate
CAS Number: 108341-18-0
Molecular Formula: C8H11NO3 • C4H6O6
Molecular Weight: 337.3 g/mol
Recommended Use: Laboratory research, pharmaceutical ingredient, chemical synthesis
Supplier Details: Name, address, emergency telephone number (refer to vendor documentation)
Classification: Acute toxicity, Hazardous to aquatic life, Eye irritation
Signal Word: Danger
Hazard Statements: Harmful if swallowed, May cause allergic skin reaction, Causes serious eye irritation, Toxic to aquatic organisms
Pictograms: Exclamation mark, aquatic hazard symbol
Precautionary Statements: Wear protective gloves and eye protection, Avoid release to the environment, If in eyes rinse cautiously, If on skin wash with plenty of water
Routes of Exposure: Eye contact, skin contact, ingestion, inhalation
Chemical Identity: L-Noradrenaline bitartrate
Common Names: Norepinephrine bitartrate
Concentration: 100%
Impurities: No known impurities affecting classification
Additional Ingredients: Not applicable (pure substance)
Inhalation: Move person to fresh air, seek medical attention if feeling unwell
Skin Contact: Remove contaminated clothing and wash skin thoroughly with soap and water, seek medical help if symptoms develop
Eye Contact: Flush with water for at least 15 minutes keeping eyelids open, seek immediate medical advice
Ingestion: Rinse mouth, drink water if conscious, seek immediate medical attention, do not induce vomiting unless instructed
Most Important Symptoms: Irritation of eyes, skin, gastrointestinal upset, possible cardiovascular effects (palpitations, hypertension), allergic reaction possible
Medical Attention: Treat symptomatically, monitor cardiovascular and respiratory function
Special Advice for Doctors: Observe for allergic or cardiovascular complications, provide symptomatic support
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Strong water jets
Specific Hazards: Combustion may produce carbon monoxide, carbon dioxide, and nitrogen oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Additional Information: Remove product from fire area if safe to do so, prevent fire-fighting water from entering drains, avoid inhalation of vapors or dust
Personal Precautions: Avoid breathing dust, wear gloves, safety goggles, and appropriate clothing
Environmental Precautions: Avoid release into sewers, surface water, or soil
Spill Cleanup Methods: Sweep up carefully without creating dust, collect in appropriate container for disposal, ventilate area thoroughly
Decontamination: Wash spill site with water after material pickup is complete, dispose of wash water according to local regulations
Reporting: Report large spills to appropriate authorities as per local, regional, and national regulations
Safe Handling: Use in well-ventilated areas, minimize dust formation, avoid direct contact with skin and eyes, avoid ingestion
Technical Measures: Ground and bond containers during transfer to avoid static discharge
Storage Requirements: Keep container tightly closed in a dry, cool, well-ventilated area away from incompatible substances
Storage Temperature: Recommended 2-8°C (refrigerated), protect from light
Incompatible Materials: Strong oxidizers, bases, acids
Further Advice: Label containers, keep away from food and drink, use only by trained personnel
Engineering Controls: Use local exhaust ventilation, safety shower, and eye wash station in work area
Occupational Exposure Limits: No established limits for this compound, treat as hazardous material
Personal Protective Equipment: Chemical resistant gloves (nitrile or neoprene), lab coat or protective suit, safety goggles, NIOSH-certified dust mask or respirator as appropriate
Hygiene Measures: Wash hands and face thoroughly after handling, do not eat or drink in working area, remove contaminated clothing
Environmental Controls: Prevent product from entering drains or watercourses
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical odor
Odor Threshold: Data not available
pH (1% water solution): Approximately 3.0–5.0
Melting Point: Approximately 243–248°C (decomposes)
Boiling Point: Decomposition before boiling
Solubility: Readily soluble in water, slightly soluble in ethanol
Specific Gravity: Not determined
Vapor Pressure: Not applicable (solid at ambient temperature)
Vapor Density: Not applicable
Partition Coefficient (log Kow): Not determined
Evaporation Rate: Not applicable
Flash Point: Not determined
Autoignition Temperature: Not determined
Decomposition Temperature: Above melting point
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions, sensitive to light and air (may darken on exposure), decomposition may occur with heat
Reactivity: May react with strong oxidizing agents, acids, or bases
Hazardous Reactions: None known under normal use
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides under fire conditions
Conditions to Avoid: Exposure to heat, moisture, strong light, contact with incompatible chemicals
Likely Routes of Exposure: Inhalation, skin, eye, ingestion
Acute Toxicity: LD50 (oral, rat): 100 mg/kg (reported for norepinephrine), potential for fatality at high doses due to cardiovascular effects
Chronic Effects: Prolonged exposure may lead to nervous system disturbances, sensitization, or tissue irritation
Skin Corrosion/Irritation: May cause mild to moderate irritation
Serious Eye Damage/Irritation: Expected to be irritating
Respiratory Sensitization: Possible with prolonged or excessive exposure
Carcinogenicity: No component listed as carcinogen by IARC, NTP, or OSHA
Reproductive Toxicity: Not established for this compound, structurally related compounds do not show teratogenicity at therapeutic doses
Mutagenicity: No data
Other Effects: May cause cardiovascular symptoms including tachycardia, hypertension, arrhythmias with significant exposure
Ecotoxicity: Harmful to aquatic life, toxicity data for fish, Daphnia, and algae not extensively studied
Persistence and Degradability: Not rapidly biodegradable, expected to persist in environment under improper disposal
Bioaccumulation Potential: Low risk due to water solubility and metabolic breakdown
Mobility in Soil: Likely to migrate through soil and groundwater given high water solubility
Other Adverse Effects: Avoid entry into watercourses, wastewater systems; long-term ecological effects require further investigation
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulation, chemical incineration preferred
Product Disposal: Small amounts may be diluted with water and neutralized before disposal, large quantities require hazardous waste disposal
Contaminated Packaging: Dispose of as unused product or as hazardous waste, ensure containers are properly rinsed and labeled
Special Precautions: Do not discharge into drains or the environment, consult with accredited waste disposal contractor
UN Number: 2811 (if classified as a toxic solid, organic, n.o.s.)
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains L-Noradrenaline bitartrate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Harmful to aquatic life
Transport Precautions: Pack in well-sealed, correctly labeled containers, avoid transport with food and feedstuffs
Transport Regulations: Follow local, national, and international guidelines including ADR, IMDG, IATA
GHS Classification: Acute toxicity (oral), Category 4; Eye irritation, Category 2A; Hazardous to aquatic environment
EU Regulation (REACH): Not registered, use for laboratory chemicals only
US TSCA Status: Not listed
SARA Title III: Not reportable under Sections 302, 304, 313
California Proposition 65: Not listed
Workplace Safety: Handle as hazardous material in accordance with established laboratory safety rules
Other Regulation: Ensure compliance with all local, state, national, and international regulations regarding chemical use, storage, and disposal
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