Product Name: L-(-)-Epinephrine-(+)-bitartrate
Synonyms: Epinephrine Bitartrate, Adrenalin Bitartrate
Chemical Formula: C13H19NO9
CAS Number: 51-42-3
Recommended Use: Laboratory chemical, pharmaceutical ingredient
Manufacturer: Registered laboratory supply distributors provide the full supplier address on request
Contact Number: Listed on procurement paperwork and safety portals for workplace reference
Emergency Contact: National Poison Control Center at 1-800-222-1222
Restrictions: For research use only, not for household or food applications
GHS Classification: Acute toxicity (oral, dermal), category 4; Eye irritation, category 2
Hazard Statements: Harmful if swallowed or absorbed through skin; Causes serious eye irritation
Signal Word: Warning
Pictograms: Exclamation mark
Precautionary Statements: Avoid contact with skin, eyes, and clothing; Wash thoroughly after handling; Do not eat, drink, or smoke while using
Potential Health Effects: Skin and eye irritation; May cause headache, nausea, arrhythmia or hypertension in sensitive individuals with significant exposure; Target organs include cardiovascular and nervous systems
Environmental Hazards: Harmful to aquatic life; Avoid release to the environment, especially near waterways
Chemical Name: L-(-)-Epinephrine-(+)-bitartrate
Concentration: >98% by weight
Impurities/Other Components: Residual water or trace organic solvents less than 1% combined
Molecular Weight: 333.30 g/mol
Ingredient Notes: Pure, pharmaceutical or laboratory-grade unless diluted or blended for application
CAS Registry Number: 51-42-3
EINECS Number: 200-109-6
Common Names: Adrenaline Bitartrate, (-)-Epinephrine Bitartrate
Eye Contact: Rinse immediately with gentle stream of running water for at least 15 minutes, lifting lids; Seek medical attention, even for mild symptoms
Skin Contact: Flush area with soap and water for 15 minutes; Remove contaminated clothing and wash before reuse; Seek medical attention if irritation occurs
Inhalation: Move person to fresh air; If breathing is difficult, use appropriate medical oxygen and seek medical help straight away
Ingestion: Rinse mouth thoroughly; Never induce vomiting unless directed by a medical professional; Give water to drink if the person is conscious; Contact poison control or seek emergency care
Flash Point: Not established for solid form
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide, depending on surrounding fire
Special Hazards: Combustion may generate toxic fumes such as nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Firefighting Precautions: Approach from upwind, use water spray to cool containers; Avoid breathing fumes
Explosion Hazard: No known risk, but dust buildup in air could present a fire hazard in poorly ventilated spaces
Personal Precautions: Use gloves and goggles; Avoid breathing dust; Ensure proper ventilation
Environmental Precautions: Prevent runoff into drains and surface water; Collect and contain material for disposal
Spill Cleanup Methods: Use damp cloth or absorbent material to sweep up solid; Place residue in appropriately labeled container; Wash spill site with water and detergent after pickup is complete
Decontamination: Wash exposed area and tools thoroughly
Disposal of Contaminants: Dispose of in accordance with local, regional, and national regulations
Handling: Handle in well-ventilated area; Avoid producing dust; Use appropriate personal protective equipment, including gloves and safety goggles; Do not eat, drink, or smoke in work areas
Storage: Store in tightly closed packaging in cool, dry, well-ventilated location; Keep out of direct sunlight and away from incompatible substances like strong oxidizing agents; Label container clearly with product name and hazard warnings; Keep away from sources of ignition or excess heat
Incompatibility: Avoid contact with oxidizing acids or bases; Reacts with strong alkalies or oxidizers
Permissible Exposure Limits: No established OSHA or ACGIH exposure limits; Use practical methods to minimize exposure
Engineering Controls: Local exhaust ventilation, chemical fume hood recommended for bulk work
Personal Protective Equipment: Chemical safety goggles, laboratory coat, gloves resistant to chemicals; Use dust mask or higher respiratory protection in case of inadequate ventilation
Hygiene Measures: Wash hands after handling; Remove contaminated clothing and wash prior to reuse
Environmental Controls: HANDLE waste following environmental safety protocols to protect runoff and air quality
Appearance: White to off-white crystalline powder
Odor: Odorless or faintly acidic
pH (1% solution): 3.0-4.5
Melting Point: 155–175°C (decomposes)
Boiling Point: Decomposes before boiling
Solubility: Soluble in water; slightly soluble in alcohol; insoluble in chloroform and ether
Vapor Pressure: Negligible at room temperature
Density: 1.5 g/cm³
Partition Coefficient: log Pow = -2.6 (calculated, for base compound)
Evaporation Rate: Not applicable
Other Data: Forms stable solutions at room temperature under neutral or acidic conditions, decomposes rapidly in alkaline conditions or on exposure to light and air
Chemical Stability: Stable under normal conditions with protection from heat, light and moisture
Instability: Decomposes quickly under alkaline conditions; Degrades with prolonged exposure to air or light
Hazardous Reactions: Reacts with oxidizing acids and strong alkalies, releasing toxic fumes
Conditions to Avoid: Light, air, moisture, elevated temperatures
Incompatible Materials: Strong oxidizers, strong bases, reducing agents
Hazardous Decomposition: Nitrogen oxides, carbon monoxide, carbon dioxide may be formed after combustion or slow degradation over time
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): 20 mg/kg; Data show potential for systemic cardiovascular effects on significant exposure
Skin/Eye Irritation: Both cold and warm solutions irritate unprotected eyes and skin in animal models and humans
Chronic Toxicity: Chronic exposure to low doses has not shown direct carcinogenicity or mutagenicity, but repeated high-level exposure may cause sensitization or allergic responses
Symptoms: Eye or skin redness, headache, dizziness, rapid pulse, palpitations, nausea
Sensitization: Cases of allergic reaction and hypersensitivity have occurred; Asthma-like symptoms in occupational exposure settings
Other Data: Not identified as carcinogenic by NTP, IARC, or OSHA
Ecotoxicity: Harmful to aquatic organisms at elevated concentrations; Data on fish and daphnia indicate moderate acute toxicity
Persistence/Degradability: Breaks down relatively quickly in the environment, but should not be released uncontrolled
Bioaccumulation: Not expected to accumulate due to high water solubility and low log Pow value
Mobility: Highly mobile in water, may reach groundwater if not contained
Aquatic Release: Risk of acute and chronic effects in aquatic ecosystems, especially at higher concentrations
Regulatory Data: Not considered Persistent, Bioaccumulative or Toxic (PBT) by European criteria; Still, all waste must be processed to minimize environmental contamination
Waste Disposal: Treat as hazardous pharmaceutical or chemical waste; Do not dispose to sewer, soil, or normal trash
Waste Handling: Place material, solid residues, and contaminated cleaning supplies in sealed, appropriately labeled hazardous waste container
Disposal Methods: Consign chemical waste to licensed hazardous waste disposal contractor; Methods include incineration in specialized facilities
Container Disposal: Thoroughly clean empty containers before recycling or disposal; Deface container labels before discard
Regulations: Local, regional, and national waste regulations apply, including hazardous waste codes (such as EPA or local environmental agency standards)
UN Number: Not regulated for transport by most major agencies
Proper Shipping Name: Not classified as a hazardous material under DOT, IATA, IMDG codes in most forms
Transport Hazard Class: None assigned
Packing Group: Not regulated as hazardous for shipping
Transport Labeling: Laboratory use only, avoid moisture and rough handling; Label with product name and chemical class; Secure well-packed container
Special Precautions: Protect from excess heat or physical damage during transit
Environmental Hazards during Transport: Avoid spillage or leaking, especially in air or sea shipment
Labelling Requirements: OSHA-compliant hazard communication labeling for laboratory chemicals
TSCA Status: Listed on US TSCA inventory
REACH Registration: Registered as a research or limited volume substance
Workplace Regulations: Compliance with OSHA Laboratory Standard (29 CFR 1910.1450), Chemical Hygiene Plan
Other Regulations: Not subject to SARA Title III, CERCLA, or California Proposition 65
ADR/RID/IMDG/IATA: Not subject to transport class-specific regulations, but observe general precautions for chemical handling and labeling
State and Local Guidance: Occupational safety, environmental release, and waste management laws apply as enforced
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