Product Name: l-Arterenol d-bitartrate
Chemical Name: Norepinephrine bitartrate
Synonyms: (-)-Norepinephrine hydrogen (R,R)-tartrate; Levarterenol bitartrate
CAS Number: 108341-18-0
Product Code: Not assigned
Intended Use: Laboratory chemical, research and development only
Manufacturer Information: Chemical supply company contact, emergency phone numbers included
Recommended Restrictions: Not for drug, household, or food use
Hazard Class: Acute toxicity (oral, dermal, inhalation), Eye irritation
GHS Label Elements: Signal word: Warning
Hazard Statements: Harmful if swallowed or inhaled; Causes serious eye irritation
Pictograms: Exclamation mark (for acute toxicity and irritation)
Precautionary Statements: Avoid breathing dust or vapors; Wash hands thoroughly after handling; Use only with adequate ventilation; In case of inadequate ventilation, wear respiratory protection
Health Hazards: May increase blood pressure, trigger cardiac stimulation, cause gastrointestinal disturbances, trigger skin or eye irritation
Emergency Overview: Contact with skin and eyes may produce irritation, ingestion or inhalation can lead to toxicity affecting cardiovascular and neurological systems
Chemical Identity: l-Arterenol d-bitartrate
Common Name: Norepinephrine bitartrate
Concentration: 98-100% (pure substance, no additives or stabilizers noted)
Molecular Formula: C8H11NO3 • C4H6O6
Molecular Weight: 337.3 g/mol
Impurities and Stabilizing Additives: None reported
Eye Contact: Flush eyes with plenty of water for at least 15 minutes, keeping eyelids open, seek medical attention
Skin Contact: Remove contaminated clothing, rinse affected area with soap and plenty of water for 15 minutes, obtain medical help if irritation develops
Inhalation: Move to fresh air, keep at rest in comfortable position, provide artificial respiration if breathing stops, seek immediate medical attention
Ingestion: Rinse mouth with water, seek medical attention right away, do not induce vomiting unless advised by medical personnel
Most Important Symptoms: Rapid heartbeat, elevated blood pressure, dizziness, irritability, severe eye or skin irritation
Note to Physician: Treat symptoms, monitor cardiovascular and central nervous system functions, supportive therapy
Suitable Extinguishing Media: Use water spray, dry chemical powder, CO2 or foam; avoid heavy water streams
Specific Hazards: Decomposes at high temperature to release carbon oxides, nitrogen oxides, toxic fumes
Protective Equipment for Firefighters: Wear self-contained breathing apparatus with full protective gear
Advice for Firefighters: Move containers from fire area if feasible, use water to cool fire-exposed containers, prevent runoff into drains
Personal Precautions: Wear protective gloves, safety goggles, lab coat, and NIOSH-approved respirator
Environmental Precautions: Avoid discharge into sewers, surface water, or soil
Clean-Up Methods: Sweep up material without creating dust, place in a properly labeled container for disposal, ventilate area, wash spill site thoroughly after cleanup
Emergency Procedures: Evacuate personnel to safe area, avoid breathing dust, provide adequate ventilation
Precautions for Safe Handling: Use in chemical fume hood, avoid inhalation, ingestion, and contact with skin and eyes, wash thoroughly after handling
Safe Storage Conditions: Store in tightly closed container, in cool, dry, well-ventilated area, away from incompatible substances such as oxidizers
Special Requirements: Protect from light and moisture, keep away from acids and bases, periodically check containers for integrity
Occupational Exposure Limits: No specific exposure limit established, treat as hazardous chemical
Engineering Controls: Use only in well-ventilated areas, chemical fume hood or local exhaust ventilation for dust
Personal Protective Equipment: Safety glasses with side-shields, chemical-resistant gloves (nitrile recommended), lab coat, appropriate dust mask or NIOSH respirator if exposure risk exists
Hygiene Measures: Avoid contact with skin, eyes, and clothing; wash hands before breaks and after finishing work
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 237-241°C
Solubility: Soluble in water, sparingly soluble in ethanol
pH (Solution): Acidic (pH around 2.5-3.5 at 1% solution)
Boiling Point: Not available
Vapor Pressure: Negligible
Density: 1.6 g/cm3 (approximate)
Partition Coefficient (log Kow): -2.1
Evaporation Rate: Not available
Flash Point: Not flammable under normal conditions
Auto-ignition Temperature: Not available
Chemical Stability: Stable under normal laboratory conditions, breaks down over time with moisture or light exposure
Reactivity: No data on violent reactivity, may react with strong oxidizers or acids
Hazardous Decomposition Products: Produces carbon monoxide, carbon dioxide, nitrogen oxides under high temperature
Conditions to Avoid: Exposure to moisture, sunlight, heat, and open flame
Incompatible Materials: Powerful oxidants, acids, bases, alkali metals
Acute Toxicity: Low to moderate toxicity by oral, dermal, and inhalation routes; reported mouse LD50 (oral) 100 mg/kg
Chronic Toxicity: No long-term studies available; effects expected to mirror acute exposure if repeatedly administered
Routes of Exposure: Ingestion, inhalation, skin/eye contact
Potential Health Effects: Increases blood pressure, may trigger rapid or irregular heartbeat, skin and eye irritation
Symptoms: Headache, dizziness, palpitations, sweating, restlessness, in severe cases risk of arrhythmia
Carcinogenicity: Not listed as carcinogenic by IARC, ACGIH, NTP, or OSHA
Mutagenicity / Reproductive Toxicity: No conclusive data available
Sensitization: No evidence for sensitization reported
Ecotoxicity: Toxic to aquatic life with potential for long lasting effects
Persistence and Degradability: Readily biodegradable under environmental conditions, breaks down in presence of sunlight and microorganisms
Bioaccumulation Potential: Low (log Kow below 0)
Mobility in Soil: Expected to have moderate mobility in soils; may leach to groundwater
Other Adverse Effects: Avoid uncontrolled release into the environment; not expected to persist in significant quantities if properly managed
Waste Treatment Methods: Dispose in accordance with local, regional, and national regulations
Product Disposal: Ensure unused product and contaminated materials go to approved hazardous waste facility
Container Disposal: Triple-rinse containers, deface labels, and consign for proper chemical waste handling
Precautions for Disposal: Avoid landfill and sewer release, do not mix with incompatible waste streams
UN Number: Not classified as dangerous for transport
UN Proper Shipping Name: Not regulated under ADR, IATA, IMDG
Transport Hazard Class: None
Packing Group: None
Environmental Hazards: Not recognized as marine pollutant
Special Precautions: Ship in tightly sealed containers, avoid physical damage during transit
Safety, Health, and Environmental Regulations: Not listed on US TSCA or EU REACH as a controlled substance; compliance with safe chemical use regulations required
Label Requirements: Signal word and hazard pictograms for laboratory chemicals
Inventory Status: Subject to chemical inventories in some jurisdictions
Other Regulations: Not subject to specific restrictions under OSHA, SARA Title III, or CAL Prop 65
Workplace Hazard Categories: Hazard Communication Standard applies for handling and labeling
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