Product Name: l-Arterenol bitartrate
Chemical Name: (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol bitartrate
Synonyms: Levonor, Noradrenaline bitartrate, (−)-Norepinephrine bitartrate
CAS Number: 108341-18-0
Molecular Formula: C8H11NO3 · C4H6O6
Molecular Weight: 337.3 g/mol
Recommended Use: Pharmaceutical intermediate, laboratory reagent
Supplier Details: Manufacturer or distributor’s full address, emergency phone number, and contact email
Emergency Overview: White or off-white crystalline powder, slightly bitter odor, hygroscopic nature, intended for controlled environments by trained professionals
Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Skin sensitization
GHS Label Elements: Pictogram: exclamation mark, health hazard. Signal word: Warning
Hazard Statements: May cause skin and eye irritation, potentially harmful if inhaled or swallowed, possible respiratory sensitizer, target organ effects on cardiovascular and central nervous systems
Precautionary Statements: Avoid breathing dust, avoid contact with skin and eyes, do not eat, drink, or smoke when using this product
Routes of Exposure: Inhalation, skin, ingestion, eye contact
Symptoms: Rapid heartbeat, headache, dizziness, skin redness, coughing or sneezing, agitation
Aggravated Medical Conditions: Asthma, cardiovascular disorders, hypertensive conditions
Chemical Identity: l-Arterenol bitartrate
Active Ingredient: l-Arterenol bitartrate (≥98%)
Impurities: Trace organic and inorganic compounds (<2% total), residual solvents below threshold limits
Ingredient Disclosure: Free of hazardous fillers or stabilizers
Formulation: Typically supplied as a pure solid for compounding or scientific use
Inhalation: Move to fresh air, provide oxygen if breathing is difficult, monitor for adverse symptoms like respiratory distress, seek medical attention
Eye Contact: Rinse cautiously with water for 15-20 minutes, lift eyelids occasionally, remove contact lenses if present and easy to do, get immediate medical help
Skin Contact: Wash gently with soap and plenty of water, remove contaminated clothing, seek medical advice if irritation persists
Ingestion: Rinse mouth, do not induce vomiting, give small quantities of water if the person is conscious and alert, seek healthcare professional evaluation
Most Important Symptoms and Effects: Hypertension, palpitations, nausea, sweating, skin and mucosal irritation
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Media: Do not use direct water jet on burning product
Specific Hazards: May emit toxic gases such as carbon oxides, nitrogen oxides under intense heat or combustive conditions
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear
Special Procedures: Move containers away if safe, cool exposed containers with water, avoid inhalation of combustion fumes
Personal Precautions: Wear gloves, protective clothing, approved dust mask or respirator, and safety glasses
Environmental Precautions: Prevent spillage from entering drains, waterways, or soil
Containment Methods: Sweep up without generating dust, place in appropriate waste disposal container, ventilate area
Cleanup Procedures: Clean traces with damp cloth and detergent, avoid dry sweeping, dispose of soiled cleaning material as hazardous waste
Decontamination: Wash area thoroughly after cleanup, avoid use of bleach or strong oxidizers
Safe Handling: Follow strict laboratory safety procedures including wearing PPE, work in a well-ventilated area, avoid dust generation, avoid contact with incompatible substances
Storage Conditions: Store in tightly closed container, protected from light, moisture, and heat, temperature range recommended 2–8°C
Incompatibilities: Strong oxidizers, acids, bases
Specific Practices: Keep away from food and beverages, restrict access to trained personnel, clearly label containers
Storage Area: Dedicated chemical cabinet or cold storage unit, spill containment trays advised
Occupational Exposure Limits: No established TLV/TWA for l-Arterenol bitartrate, minimize exposure through handling controls
Engineering Controls: Use fume hood or local exhaust ventilation, keep work area clean
Personal Protective Equipment: Gloves (nitrile or neoprene), impervious lab coat, chemical splash goggles, respiratory protection for dust
Hygiene Measures: Wash hands and face before eating, drinking, or smoking, wash all contaminated clothing before reuse
Monitoring: Regular workplace assessments and air monitoring in high-volume settings
Appearance: White to off-white crystalline powder
Odor: Slightly bitter, faint characteristic
pH: 3.0–4.0 (5% aqueous solution)
Melting Point: 140–150°C (decomposition)
Solubility: Easily soluble in water, slightly soluble in ethanol, negligible in organic solvents
Partition Coefficient (log Kow): −2.7 (estimated)
Boiling Point: Not applicable (decomposes)
Density: 1.3–1.4 g/cm³ at 20°C
Vapor Pressure: Negligible
Other Data: Hygroscopic, may clump or cake if exposed to moisture
Chemical Stability: Stable under recommended storage, sensitive to light and air, decomposes on heating
Conditions to Avoid: Excessive heat, open flames, direct sunlight, humidity
Materials to Avoid: Strong acids, bases, oxidizers, certain metals
Hazardous Reactions: Risk of hazardous decomposition with incompatible substances
Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, toxic fumes under extreme conditions
Acute Toxicity: Oral LD50 (rat): 61 mg/kg (as norepinephrine base, literature data), data for bitartrate salt suggest similar or slightly lower values
Skin Corrosion/Irritation: May cause mild to moderate irritation
Eye Damage/Irritation: Potential for irritation, possible eye redness and watering
Respiratory Sensitization: Provokes coughing or sneezing with inhalation, especially in sensitive individuals
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: No clear evidence in standard assays
Reproductive Toxicity: Limited specific evidence, caution advised in pregnancy or breastfeeding
Target Organ Effects: Cardiovascular system, central nervous system on acute exposure
Chronic Toxicity: Long-term effects not well elucidated, avoid repeated or prolonged exposures
Aquatic Toxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Expected to undergo moderate biodegradation in soil and water
Bioaccumulation Potential: Low (high water solubility, low log Kow)
Mobility in Soil: Likely high due to hydrophilic nature
Other Information: Do not discharge into environment or watercourses; proper containment is crucial for spill prevention
Waste Treatment Methods: Collect waste in tightly sealed, clearly labeled hazardous waste containers, dispose through licensed chemical waste contractor
Incineration: Requires high-temperature incinerator with off-gas treatment for pharmaceuticals
Contaminated Packaging: Dispose using the same controls as bulk chemical
Other Information: Do not flush into sewer, prevent environmental contamination, comply with local, state, national legislation
UN Number: Consult the latest UN recommendations; typically not regulated in small quantities
Transport Hazard Class: Typically listed as non-hazardous, but verify with carrier
Packing Group: Usually not assigned
Special Precautions: Ensure packaging prevents exposure to moisture, light, and movement during transport
Labeling: Use full product labeling as per regulations, include hazard pictograms where required
OSHA Status: Regulated as hazardous chemical under the Hazard Communication Standard
TSCA Inventory: Could be excluded for pharmaceutical or research use
REACH Status: Pre-registration or exempt for medicinal use, check manufacturer’s compliance
SARA Title III: Not listed as toxic or hazardous under typical reporting thresholds
WHMIS Classification: D2B (Toxic material causing other toxic effects)
International Inventories: Inclusion varies based on jurisdiction, reference specific country’s chemical control law
Other Regulations: Handle with procedures typical for pharmaceutical intermediates, follow institutional guidelines for research and handling
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